A REVIEW ON RESTORATIVE AND THERAPEUTIC POTENTIAL OF NUTRACEUTICALS

A REVIEW ON NUTRACEUTICALS

Authors

  • ABHINAY KUMAR DWIVEDI Department of Pharmacognosy, Bansal College of Pharmacy, Bhopal, Madhya Pradesh, India.

DOI:

https://doi.org/10.22159/ijhs.2023.v11i1.48242

Keywords:

Nutraceuticals, dietary supplements, probiotic, prebiotic, antioxidants, spices, health supplements

Abstract

The food products basically known for its nutritional profile, nutraceuticals are food or food derived products with additional characteristic to minimize occurrence and prevention of certain chronic diseases. The rational use of these nutraceuticals not merely gives us nutrition and restoration but also support to fight against diseases and overcome illness. Wide variety of food and dietary supplements i.e. dietary fiber, probiotics, prebiotics, polyunsaturated fatty acids, antioxidant vitamins, carotenoids, polyphenols and spices have proven to potential health benefit and could be used as nutraceuticals. This review primarily focused on food source, health benefit, regulatory challenges and market potential of nutraceuticals.

References

Smith R. “Let food be thy medicine”. BMJ 2004;328,7433. PMCID: PMC318470.

Antini A, Novellino E. Nutraceuticals - shedding light on the grey area between pharmaceuticals and food. Expert Rev Clin Pharmacol 2018;11:545-7.

Ward WE, Chilibeck PD, Comelli EM, Duncan AM, Phillips SM, Robinson LE, et al. Research in nutritional supplements and nutraceuticals for health, physical activity, and performance: Moving forward (1). Appl Physiol Nutr Metab 2019;44:455-60.

Fernandes SD, Narayana RC, Narayanan AV. The emergence of India as a blossoming market for nutraceutical supplements: An overview. Trends Food Sci Technol 2019;86:579-85.

Pandey MM, Rastogi S, Rawat AK. Indian ancient ayurvedic system of medicine and nutritionalsupplementation. Evid Based Complement Alternat Med 2013;2013:376327.

Kotha RR, Luthria DL. Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules 2019;24:2930.

Puri V, Nagpal M, Singh I, Singh M, Dhingra GA, Huanbutta K, et al. A Comprehensive review on nutraceuticals: Therapy support and formulation challenges. Nutrients 2022;14:4637.

Souyoul SA, Saussy KP, Lupo MP. Nutraceuticals: A review. Dermatol Ther (Heidelb) 2018;8:5-16.

Ruby S, Prakash S, Kumar VP. A comprehensive review on nutraceuticals. Int J Pharm Sci Rev Res 2012;68:136-48.

Hardy G. Nutraceuticals and functional foods: Introduction and meaning. Nutrition 2000;16:688-9.

Shinde N, Bangar B, Deshmukh S, Kumbhar P. Nutraceuticals: A review on current status. Res J Pharm Techol 2014;7:110-3.

Žuntar I, Petric Z, Kovačević DB, Putnik P. Safety of probiotics: Functional fruit beverages and nutraceuticals. Foods 2020;9:947.

Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev 2017;12:CD006095.

Vouloumanou EK, Makris GC, Karageorgopoulos DE, Falagas ME. Probiotics for the prevention of respiratory tract infections: A systematic review. Int J Antimicrob Agents 2009;34:10.e1-10.

Jain N, Radhakrishnan A, Kuppusamy G. Review on nutraceuticals: Phase transition from preventive to protective care. J Complement Integr Med 2022;19:553-70.

Bee TN, Abdolrahman RH. Nutraceuticals: Nutritionally functional foods-an overview. Biomed J Sci Tech Res 2019;4:11480-2.

Zugravu C, Otelea MR. Dark chocholate: To eat or not to eat? A review. J AOAC Int 2019;102:1388-96.

Chanda S, Tiwari RK, Kumar A, Singh K. Nutraceuticals inspiring the current therapy for lifestyle diseases. Adv Pharmacol Sci 2019;2019:6908716.

Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. Marine n - 3 fatty acids and prevention of cardiovascular disease and cancer. N Engl J Med 2019;380:23-32.

Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med 2014;5:1487-99.

Abdel-Aal EM, Akhtar H, Zaheer K, Ali R. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients 2013;5:1169-85.

Rita S, Anupriya N, Shivanand P. Emerging role of nutraceuticals in the management of hypertension: A systematic review. J Pharm Sci Res 2023;14:62-70.

Maurya S, Sharma N, Mamta T, Singh A, Kajol. A review article on nutraceuticals. Int Res J Modern Eng Technol Sci 2022;4:4329-42.

Mali S, Rathod S, Kale N, Shinde N. Overview of nutraceuticals. Asian J Pharm Res 2022;12:61.

Khan MA, Singh R, Bhatt S, Singh N, Shukla DT. Overview of nutraceuticals in the prevention of diseases. Int J Clin Sci Med Res 2022;2:109-16.

Gupta SK, Yadav SK, Patil SM. Nutraceuticals- scope and opportunity of Indian Healthcare Market. Intern J Res Dev Pharm Life Sci 2013;2:478-81.

Ramaa CS, Shirode AR, Mundada AS, Kadam VJ. Nutraceuticals-an emerging era in the treatment and prevention of cardiovascular diseases. Curr Pharm Biotechnol 2006;7:15-23.

Singh V, Mahaur S, Kushwaha SK. Nutraceuticals: A new golden era in health and disease. Asian J Res Chem 2018;11:652-8.

Verma G, Mishra MK. A review on nutraceuticals: Classification and its role in various diseases. Int J Pharm Ther 2016;7:152-60.

El-Beltagi HS, Mohamed AA, Mohamed HI, Ramadan K, Barqawi AA, Mansour AT. Phytochemical and potential properties of seaweeds and their recent applications: A review. Mar Drugs 2022;20:342.

Mannucci C, Casciaro M, Sorbara EE, Calapai F, Di Salvo E, Pioggia G, et al. Nutraceuticals against oxidative stress in autoimmune disorders. Antioxidants (Basel) 2021;10:261.

De Pascual-Teresa S, Moreno DA, García-Viguera C. Flavanol and anthocyanin in cardiac health: A review of current evidence. Int J Mol Sci 2010;11:1679-703.

Johnson EJ. The role of carotenoids in human health. Nutr Clin Care 2002;5:56-65.

Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2009;2:270-8.

Spencer JP, El Mohsen MM, Minihane AM, Mathers JC. Biomarkers of the intake of dietary polyphenols: Strengths, limitations and application in nutrition research. Br J Nutr 2008;99:12-22.

Beckman CH. Phenolic-storing cells: Keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol Mol Plant Pathol 2000;57:101-10.

Graf BA, Milbury PE, Blumberg JB. Flavonols, flavones, flavanones, and human health: Epidemiological evidence. J Med Food 2005;8:281-90.

Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005;81:317S-25.

Kondratyuk TP, Pezzuto JM. Natural product polyphenols of relevance to human health. Pharm Biol 2004;42:46-63.

Driscoll MS, Kwon EK, Skupsky H, Kwon SY, Grant-Kels JM. Nutrition and the deleterious side effects of nutritional supplements. Clin Dermatol 2010;28:371-9.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press; 2001.

Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007;51:301-23.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press; 2000.

Ho E, Courtemanche C, Ames BN. Zinc deficiency induces oxidative DNA damage and increases p 53 expression in human lung fibroblasts. J Nutr 2003;133:2543-8.

Palthur MP, Palthur SS, Chitta SK. Nutraceuticals: A conceptual definition. Int J Pharm Pharm Sci 2010;2:19-27.

Verma B, Popli H. Regulations of nutraceuticals in India & us. Pharma Innov J 2018;7:811-6.

Blaze J. A comparison of current regulatory frameworks for nutraceuticals in Australia, Canada, Japan, and the United States. Innov Pharm 2021;12:3694.

Papetti A. Nutraceuticals: Health benefits and government regulations. Curr Res Nutr Food Sci 2019;7:1-4.

Domínguez Díaz L, Fernández-Ruiz V, Cámara M. The frontier between nutrition and pharma: The international regulatory framework of functional foods, food supplements and nutraceuticals. Crit Rev Food Sci Nutr 2020;60:1738-46.

Thakkar S, Anklam E, Xu A, Ulberth F, Li J, Li B, et al. Regulatory landscape of dietary supplements and herbal medicines from a global perspective. Regul Toxicol Pharmacol 2020;114:104647.

Turner-Ravana N. Nutraceutical and functional food regulations in the United States and around the world. J Nutr Educ Behav 2020;52:989.

Ismail SF, Daud M, Azmi IM, Jalil JA. Enhancing regulation of nutraceutical products in Malaysia: Lessons from Japan. IIUM Law J 2020;28:351-72.

Bailey RL. Current regulatory guidelines and resources to support research of dietary supplements in the United States. Crit Rev Food Sci Nutr 2020;60:298-309.

Sachdeva V, Roy A, Bharadvaja N. Current prospects of nutraceuticals: A review. Curr Pharm Biotechnol 2020;21:884-96.

Chauhan B, Kumar G, Kalam N, Ansari SH. Current concepts and prospects of herbal nutraceutical: A review. J Adv Pharm Technol Res 2013;4:4-8.

Bahorun T, Aruoma OI, Neergheen-Bhujun VS. Phytomedicines, nutraceuticals, and functional foods regulatory framework: The African context. In: Bagchi D, editor. Nutraceutical and Functional Food Regulations in the United States and Around the World. New York, NY, USA: Academic Press; 2019. p. 509-21.

Brower V. Nutraceuticals: Poised for a healthy slice of the healthcare market? Nat Biotechnol 1998;16:728-31.

Da Costa JP. A current look at nutraceuticals-key concept and future prospect. Trends Food Sci Technol 2017;62:68-78.

Chopra AS, Lordan R, Horbańczuk OK, Atanasov AG, Chopra I, Horbańczuk JO, et al. The current use and evolving landscape of nutraceuticals. Pharmacol Res 2022;175:106001.

Jha D, Jain V, Sharma B, Kant A, Garlapati VK. Microalgae‐based pharmaceuticals and nutraceuticals: An emerging field with immense market potential. ChemBioEng Rev 2017;4:257-72.

Published

06-06-2023

How to Cite

DWIVEDI, A. K. (2023). A REVIEW ON RESTORATIVE AND THERAPEUTIC POTENTIAL OF NUTRACEUTICALS: A REVIEW ON NUTRACEUTICALS. Innovare Journal Health Sciences, 11(1), 25–28. https://doi.org/10.22159/ijhs.2023.v11i1.48242

Issue

Section

Articles

Most read articles by the same author(s)