3D ORGAN PRINTING: A FUTURE PROSPECT OF MEDICAL SCIENCES IN ORGAN TRANSPLANTATION
Abstract
Tissue engineering technology promising tool to solve the organ transplantation crisis. The organ bio-printing (or 3D organ printing) is the next generation alternative for organ transplantation. The structural and viscoelastic properties of assembling networks of the extracellular matrix protein type-I collagen by means of phase contrast microscopy and rotating disk rheometry. According to Steinberg differential adhesion hypothesis (DAH) the self-assembly of living cells into tissues of a specific cell type possesses a specific adhesion apparatus that combined with cell motility leads to cell assemblies of various cell types in the lowest adhesive energy state. The initial stage of the assembly is a nucleation process of collagen monomers associating to randomly distribute branched clusters with extensions of several microns. Eventually a sol-gel transition takes place, which is due to the interconnection of these clusters.
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