CONDUCTOMETRIC TITRATION METHOD FOR DETERMINATION OF ETILEFRINE HYDROCHLORIDE, FENTOTEROL HYDROBROMIDE AND PIPAZETHATE HYDROCHLORIDE USING SILVER NITRATE

Abstract

 

ABSTRACT

 

Objective: The objective of this work is to develop a simple, precise, rapid, and low-cost conductometric method for determination of etilefrine hydrochloride, fenoterol hydrobromide and pipazethate hydrochloride in pure form and in pharmaceutical formulations using silver nitrate.

Method: The method is based on the precipitation of chloride or bromide ions coming from the cited drugs with silver ions yielding silver chloride or silver bromide and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-10 mg, various experimental conditions were established.

Results :     Results obtained showed good recoveries with relative standard deviation of 0.684, 0.817 and 0.864 for etilefrine hydrochloride, fenoterol hydrobromide and pipazethate hydrochloride, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations,results were successfully comparable to the official or reference methods.

Conclusion: Simple and rapid procedure described in this work can be an alternative to the more complex and expensive methods for assay of the cited drugs.

 

Keywards:  Conductometric titration,   etilefrine , fenoterol , pipazethate .