NUTRACEUTICALS AND HERBALS AS ADJUVANTS IN THE CHEMOTHERAPY OF CANCER? A REVIEW

Authors

  • JOHN MANI PHILIPS NATHALA Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • SHIVASHREE S Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • SAHYADRI M Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • MANJULA SN Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • VIPAN K PARIHAR Department of Radiation Oncology, University of California, Irvine, California, USA.

DOI:

https://doi.org/10.22159/ijms.2020.v8i2.36593

Keywords:

Nutraceuticals, Herbals, Chemotherapy, Cancer, Adjuvant therapy

Abstract

Cancer is the third leading cause of death worldwide. The current cancer treatments such as chemotherapy and radiotherapy resulting in the development of unintended adverse effects that reduce the quality of life and economic burden in oncology patients. Nutraceuticals along with food value have natural bioactive components that have reassuring therapeutic properties in several diseases. Herbs of significant interest have been proven to prevent and treat various types of cancer and also reduce the side effects of chemotherapy and radiotherapy. The efficacy of nutraceuticals and herbs such as chemopreventive and chemotherapy is highlighted. We conclude that further studies are required to countersign the targeted approaches and efficacy of herbs and nutraceuticals in cancer patients as adjuvant therapy.

References

Cancer. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer.

Weller D, Vedsted P, Rubin G, Walter FM, Emery J, Scott S, et al. The Aarhus statement: Improving design and reporting of studies on early cancer diagnosis. Br J Cancer 2012;106:1262-7.

Cancer and Aging the Inflammatory Connection. Available from: http://www.aginganddisease.org/article/2017/2152-5250/ad-8-5-611.html.

Kirthi C, Afzal A, Reddy M, Aamir Ali S, Yerramilli A, Sharma S. A study on the adverse effects of anticancer drugs in an oncology center of a tertiary care hospital. Int J Pharm Pharm Sci 2014;6:580-3.

Sunny S. Assessment of adverse effects of most commonly prescribed anticancer drugs in a tertiary care teaching hospital. Indian J Pharm Pract 2017;10:270-5.

Chopra D, Rehan HS, Sharma V, Mishra R. Chemotherapy-induced adverse drug reactions in oncology patients: A prospective observational survey. Indian J Med Paediatr Oncol 2016;37:42-6.

Baldo P, Fornasier G, Ciolfi L, Sartor I, Francescon S. Pharmacovigilance in oncology. Int J Clin Pharm 2018;40:832-41.

How Radiation Therapy Can Affect Different Parts of the Body. Available from: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/radiation/effects-on-different-parts-of-body.html.

Baena Ruiz R, Salinas Hernández P. Diet and cancer: Risk factors and epidemiological evidence. Maturitas 2014;77:202-8.

Wargovich MJ, Morris J, Brown V, Ellis J, Logothetis B. Nutraceutical use in late-stage cancer. Cancer Metastasis Rev 2012;29:503-10.

Willett WC, Koplan JP, Nugent R, Dusenbury C, Puska P, Gaziano TA. Prevention of chronic disease by means of diet and lifestyle changes. In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, editors. Disease Control Priorities in Developing Countries. 2nd ed. Washington, DC: World Bank; 2006.

Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4:118-26.

Santini A, Novellino E. To nutraceuticals and back: Rethinking a concept. Foods 2017;6:e74.

Varzakas T, Zakynthinos G, Verpoort F. Plant food residues as a source of nutraceuticals and functional foods. Foods 2016;5:88.

Kitts D. Bioactive substances in food: Identification and potential uses. Can J Physiol Pharmacol 1994;72:423-34.

Arruebo M, Vilaboa N, Sáez-Gutierrez B, Lambea J, Tres A, Valladares M, et al. Assessment of the evolution of cancer treatment therapies. Cancers (Basel) 2011;3:3279-330.

Herrero R, Potischman N, Brinton LA, Reeves WC, Brenes MM, Tenorio F, et al. A case-control study of nutrient status and invasive cervical cancer. I. Dietary indicators. Am J Epidemiol 1991;134:1335-46.

National Research Council (US) Committee on Nutrition, and Cancer. 17th Relationship of Diet to Cancer at Specific Sites. United States: National Academies Press; 1982.

Chemo and Radiation. Nutrition and Cancer. Available from: https://www.nutritioncancer.com.

Tapiero H, Townsend DM, Tew KD. The antioxidant role of selenium and seleno-compounds. Biomed Pharmacother 2003;57:134-44.

Chen S, Wang Z, Huang Y, O’Barr SA, Wong RA, Yeung S, et al. Ginseng and anticancer drug combination to improve cancer chemotherapy: A critical review. Evid-Based Complement Altern Med 2014;2014:168940.

Demidov LV, Manziuk LV, Kharkevitch GY, Pirogova NA, Artamonova EV. Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: A randomized, pilot, phase II clinical study with a 7-year follow-up. Cancer Biother Radiopharm 2008;23:477-82.

Jain R, Rao B. Critical analysis of India’s national mission on medicinal plants (NMMP) in providing access to quality botanical drugs to improve public health. J Ayurveda Integr Med 2015;6:198-207.

Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview. Medicines 2018;5:e93.

Al-Snafi AE. Chemical constituents and pharmacological activities of Lantana camara a review. Asian J Pharm Clin Res 2019;12:10-20.

Demain AL, Vaishnav P. Natural products for cancer chemotherapy. Microb Biotechnol 2011;4:687-99.

Greenwell M, Rahman PK. Medicinal plants: Their use in anticancer treatment. Int J Pharm Sci Res 2015;6:4103-12.

Lichota A, Gwozdzinski K. Anticancer activity of natural compounds from plant and marine environment. Int J Mol Sci 2018;19:3533.

Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Altern Med 2013;2013:302426.

Albulescu M. Phytochemicals in Antitumor Herbs and Herbal Formulas. Phytochemicals Isolation, Characterisation and Role in Human Health; 2015. Available from: http://www.intechopen.com/books/phytochemicals-isolation-characterisation-and-role-in-human-health/phytochemicals-in-antitumor-herbs-and-herbal-formulas. [Last accessed on 2020 Jan 14].

Safarzadeh E, Shotorbani SS, Baradaran B. Herbal medicine as inducers of apoptosis in cancer treatment. Adv Pharm Bull 2014;4 Suppl 1:421-7.

Ismail T, Calcabrini C, Diaz AR, Fimognari C, Turrini E, Catanzaro E, et al. Ellagitannins in cancer chemoprevention and therapy. Toxins 2016;8:151.

Sharma P, McClees SF, Afaq F. Pomegranate for prevention and treatment of cancer: An update. Mol J Synth Chem Nat Prod Chem 2017;22:177.

Moudi M, Go R, Yien CY, Mohd N. Vinca Alkaloids. Int J Prev Med 2013;4:1231-5.

Quintão NL, Santin JR, Stoeberl LC, Corrêa TP, Melato J, Costa R. Pharmacological treatment of chemotherapy-induced neuropathic pain: PPARγ agonists as a promising tool. Front Neurosci 2019;13:907.

Periwinkle: A Herbal Powerhouse, Side Effects and Dosage, HealthXP. Available from: https://www.healthxp.in/periwinkle-a-herbal-powerhouse-side-effects-dosage. [Last accessed on 2020 Jan 14].

Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett 1995;94:79-83.

Klinger NV, Mittal S. Therapeutic potential of curcumin for the treatment of brain tumors. Oxid Med Cell Longev 2016;2016;9324085.

Park W, Amin AR, Chen ZG, Shin DM. New perspectives of curcumin in cancer prevention. Cancer Prev Res (Phila) 2013;6:387-400.

Khan MA, Chen HC, Tania M, Zhang DZ. Anticancer activities of Nigella sativa (black cumin). Afr J Tradit Complement Altern Med 2011;8:226-32.

Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F. Nigella sativa L. (Black cumin): A promising natural remedy for wide range of illnesses. Evid Based Complement Altern Med 20192019:1528635.

Majdalawieh AF, Fayyad MW. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med 2016;7:173-80.

Salim EI. Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay. Oncol Lett 2010;1:913-24.

Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine 2002;9:69-74.

Pellati F, Borgonetti V, Brighenti V, Biagi M, Benvenuti S, Corsi L. Cannabis sativa L. and nonpsychoactive cannabinoids: Their chemistry and role against oxidative stress, inflammation, and cancer. BioMed Res Int 2018;2018:1691428.

Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol 2011;163:1411-22.

Dariš B, Tancer Verboten M, Knez Ž, Ferk P. Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosn J Basic Med Sci 2019;19:14-23.

Tapley P, Kellett S. Cannabis-based medicines and the perioperative physician. Perioper Med (Lond) 2019;8:19.

Tariq AL, Reyaz AL. Isolation of cannabinoids from the plant Cannabis sativa and its potential anticancer activity. Int J Drug Dev Res 2012;4:241-6.

Lamm DL, Riggs DR. The potential application of Allium sativum (garlic) for the treatment of bladder cancer. Urol Clin North Am 2000;27:157-62, 11.

Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Biofactors 2006;26:93-103.

Banu KS, Cathrine DL, Britto DJ. In vitro Anticancer Activity of Carica papaya. 6th International Conference on Emerging Trends in Engineering, Technology, Science and Management; 2017.

Yuen JW, Gohel MD. Anticancer effects of Ganoderma lucidum: A review of scientific evidence. Nutr Cancer 2005;53:11-7.

Sohretoglu D, Huang S. Ganoderma lucidum polysaccharides as an anti-cancer agent. Anticancer Agents Med Chem 2018;18:667-74.

Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, et al. Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo. Nutr Cancer 2009;61:696-707.

Prasad S, Kalra N, Shukla Y. Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice. Mol Nutr Food Res 2007;51:352-9.

Imran M, Arshad MS, Butt MS, Kwon JH, Arshad MU, Sultan MT. Mangiferin: A natural miracle bioactive compound against lifestyle related disorders. Lipids Health Dis 2017;16:84.

Mohan M, Kamble S, Satyanarayana J, Nageshwar M, Reddy N. Protective effect of Solanum torvum on doxorubicin induced hepatotoxicity in rats. 2011;3:131-8.

Panigrahi S, Sundaram MM, Natesan R, Pemiah B. Anticancer activity of ethanolic extract of Solanum torvum SW. Int J Pharm Pharm Sci 2014;6:93-8.

Meera R, Chidambaranathan N. Anti cancer activity of ethanolic extract of Crateva magna Lour (DC) against Ehrlich ascitic carcinoma cell lines in mice. J Pharm Sci 2017;9:5.

Deep A, Mruthunjaya K, Manjula SN. Antitumor activity of Crateva magna in transplantable tumor models in mice. Asian J Pharm Clin Res 2019;12:233-40.

Moga MA, Bălan A, Anastasiu CV, Dimienescu OG, Neculoiu CD, Gavriș C. An overview on the anticancer activity of Azadirachta indica (Neem) in gynecological cancers. Int J Mol Sci 2018;19:3898.

Hao F, Kumar S, Yadav N, Chandra D. Neem components as potential agents for cancer prevention and treatment. Biochim Biophys Acta 2014;1846:247-57.

Alzohairy MA. Therapeutics Role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Alternat Med 2016;2016:7382506.

Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, et al. Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. J Biol Chem 2010;285:35406-17.

Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, et al. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. J Biol Chem 2011;286:1134-46.

Bodduluru LN, Kasala ER, Thota N, Barua CC, Sistla R. Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms. Toxicol In vitro 2014;28:1026-35.

Sharma C, Vas AJ, Goala P, Gheewala TM, Rizvi TA, Hussain A. Ethanolic neem (Azadirachta indica) leaf extract prevents growth of MCF-7 and HeLa cells and potentiates the therapeutic index of cisplatin. J Oncol 2014;2014:321754.

Published

01-03-2020

How to Cite

PHILIPS NATHALA, J. M., S, S., M, S., SN, M., & PARIHAR, V. K. (2020). NUTRACEUTICALS AND HERBALS AS ADJUVANTS IN THE CHEMOTHERAPY OF CANCER? A REVIEW. Innovare Journal of Medical Sciences, 5–10. https://doi.org/10.22159/ijms.2020.v8i2.36593

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Section

Review Article(s)