ACCLAIMED MEDICINAL PLANTS USED FOR THE PREVENTION AND TREATMENT OF CORONAVIRUS DISEASE 2019: CONCERNS ON SAFETY LEVELS

Authors

  • RITA MANEJU SUNDAY Department of Medical Biotechnology, National Biotechnology Development Agency, Lugbe, Abuja, Nigeria.

DOI:

https://doi.org/10.22159/ijms.2021.v9i4.41768

Keywords:

Severe acute respiratory syndrome coronavirus 2, Ginger, Garlic, Turmeric, Immunostimulators

Abstract

Medicinal plants are being used all over the world for the prevention, treatment, and management of diseases. Most consumers assume that medicinal plants have no toxic effect because they are plant natural products. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 which originated from Wuhan in China, is a current pandemic that is spreading globally. This disease has led to mortality of humans all over the world. There are reports from research that plants with antiviral, antioxidant, anti-inflammatory, or immunostimulatory activity might help in the treatment and prevention of this disease; and these have led to the increase in intake of medicinal plants with these activities all over the world. However, preclinical and clinical studies have not been carried out on some of these plants to confirm their use in prevention and treatment of COVID-19. Furthermore, the actual dose of some of these plant products for the prevention of the disease is unknown. This review discusses the use of medicinal plants including turmeric, garlic, and ginger for the treatment and prevention of COVID-19 and their possible toxic effects. In conclusion, medicinal plants should be taken in moderation in other to prevent adverse effects which include inflammation, nausea, vomiting, fever, and mortality.

References

Davidson-Hunt I. Ecological ethnobotany: Stumbling toward new practices and paradigms. MASAJ 2000;16:1-13.

Maqbool M, Dar MA, Gani I, Mir SA, Khan M. Herbal Medicines as an alternative source of therapy: A review. World J Pharm Pharm Sci 2019;8:374-80.

Philomena G. Concerns regarding the safety and toxicity of medicinal plants an overview. J Appl Pharm Sci 2011;1:40-4.

Raghavendra HL, Kekuda TR. Ethnobotanical uses, phytochemistry and pharmacological activities of Peperomia pellucid (L.) Kunth (Piperaceae) a review. Int J Pharm Pharm Sci 2018;10:1-7.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461-77.

Cai YZ, Luo Q, Sun M, Corker H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancancer. Life Sci 2004;74:2157-84.

Sen A. Acute rhematic cardiac associated with Schoenlein-Henoch vasculitis. Anadolu Kardivol Derg 2012;10:465-6.

Paul R, Prasad M, Sah NK. Anticancer biology of Azadirachta indica L (Neem): A mini review. Cancer Biol Ther 2011;12:467-76.

Liu HY, Qui NX, Ding HH, Yao RQ. Polyphenols content and antioxidant capacity of 68 Chinese herbals suitable for medical or food uses. Food Res Intern 2008;41:363-70.

Webster D, Taschereau P, Lee TD, Jurgens T. Immunostimulant properties of Heracleum maximum. Bartr. J. Ethnopharmacol 2006;106:360-3.

Kocaadam B, Sanlie N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr 2017;57:2889-95.

Nuutila AM, Puupponen-Pimiä R, Aarni M, Oksman-Caldentey KM. Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem 2003;81:485-93.

Jolad SD, Lantz RC, Chen GJ, Bates RB, Timmermann BN. Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production. Phytochemistry 2005;66:1614-35.

Murugan S, Prathiba S, Abhaya M, Fujita AA. COVID-19: An update on the epidemiological status of South India. Int J Pharm Pharm Sci 2020;12:15-8.

Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function and antigenicity of the sars-cov-2 spike glycoprotein. Cell 2020;181:281-92.e6.

Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020;395:470-3.

Bedford J, Enria D, Giesecke J, Heymann DL, Ihekweazu C, Kobinger G, et al. For the WHO strategic and technical advisory group for infectious hazards. COVID-19: Towards controlling of a pandemic. Lancet 2020;395:1015-8.

Cheepsattayakorn A, Cheepsattayakorn R. Proximal origin and phylogenetic analysis of COVID-19 (2019-nCoV or SARS-CoV-2). EC Microbiology 2020;19:9-12.

World Health Organization. Available from: https://www.covid 19.who. int. [Last accessed on 2021 April 10].

Adhikari SP, Meng S, Wu Y, Mao YP, Ye RX, Wang QZ, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: As coping review. Infect Dis Poverty 2020;9:1-12.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506.

Ren Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS coronavirus. J Virol 2020;94:1-9.

Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depend on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020;181:271-80.e8.

Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, et al. COVID-19: Consider cytokine storm syndromes and immunosuppression. Lancet 2020;395:1033-4.

Zhang L, Liu Y. Potential interventions for novel corona virus in China: A systematic review. J Med Virol 2020;92:479-90.

Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur. Cytokine Netw 2001;12:290-6.

Pawar HA, Pawar S, Pawar PA. A review on benefits and toxicities of some popular herbs. Int J Res Ayurveda Pharm 2011;2:1068-72.

Sunday RM, Ilesanmi OR, Obuotor EM. Acute and sub-chronic oral toxicity of Anthocleista vogelii (Cabbage tree) root hydroethanolic extract in Albino rats. Br J Pharm Res 2016;12:1-9.

World Health Organization. The WHO traditional medicine programme: Policy and implementation. Int Tradit Med Newsl 1985;1:1-5.

Engdal S, Klepp O, Nilsen OG. Identification and exploration of herb-drug combinations used by cancer patients. Integr Cancer Ther 2009;8:29-36.

Hewlings S, Kalman D. Curcumin: A review of its’ effects on human health. Foods 2017;6:1-11.

Nwaekpe JO, Anyaegbunam HN, Okoye BC, Asumugha GN. Promotion of turmeric for the food/pharmaceutical industry in Nigeria. Am J Exp Agric 2015;8:335-41.

Lekshmi PC, Arimboor R, Nisha VM, Menon AN, Raghu KG. In vitro antidiabetic and inhibitory potential of turmeric (Curcuma longa L) rhizome against cellular and LDL oxidation and angiotensin converting enzyme. J Food Sci Technol 2014;51:3910-7.

Dony CM, Wei-Li H. Antiviral potential of curcumin. J Funct Foods 2018;40:692-9.

Araujo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 2001;96:723-8.

Christopher D, Lao TR, Mack N, Daniel DH, Sandra IM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006;6:10.

Chauhan PS, Satti NK, Suri KA, Amina M, Bani S. Stimulatory effects of Cuminum cyminum and flavonoid glycoside on cyclosporine-A and restraint stress induced immune-suppression in Swiss Albino mice. Chem Biol Interact 2010;185:66-72.

Gaber EB, Beshbishy AM, Lamiaa GW, Yaser HA, Ahmed AA, Mohamed EA, et al. Chemical constituents and pharmacological activities of garlic (Allium sativum L.): A review. Nutrients 2020;12:872.

Mehrbod P, Amini E, Tavassoti-Kheiri M. Antiviral activity of garlic extract on Influenza virus. Iran J Virol 2009;2:8-15.

Ikpa CBC, Tochukwu OD, Christian EE, Ikezu UJ. Potential plants for treatment and management of COVID-19. Acad J Chem 2020;5:2521.

Rana SV, Pal R, Vaiphei K, Singh K. Garlic hepatotoxicity: Safe dose of garlic. Trop Gastroenterol 2006;27:26-30.

Ahmad N, Katiyar SK, Mukhtar H. Antioxidants in chemoprevention of skin cancer. Curr Probl Dermato 2001;29:128-39.

Young HY, Luo YL, Cheng HY, Hsieh WC, Liao JC, Peng WH. Analgesic and anti-inflammatory activities of [6]-gingerol. J Ethnopharmacol 2005;96:207-10.

Jung SC, Kuo CW, Chia FY, Den ES, Lien CC. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract celllines. J Ethnopharmacol 2013;145:146-51.

Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a Type 2 diabetes model of rats. J Med Food 2008;11:152-9.

Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease? Int J Cardiol 2009;131:408-9.

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST,Sung B, Anand P. Potential of spice-derived phytochemicals for cancer prevention. Plant Med 2008;74:1560-9.

Thirumalaisamy R, Murugan P, Srinivasan P, Arjunan S, Selvankumar T. Phytochemical 6-gingerol a promising drug of choice for COVID. Int J Adv Sci Eng 2020;6:1482-9.

Kaul PN, Joshi BS. Alternative medicine: Herbal drugs and their critical appraisal-part II. Prog Drug Res 2001;57:1-75.

Wilkinson JM. Effect of ginger tea on the fetal development of Sprague- Dawley rats. Reprod Toxicol 2000;14:507-12.

Chang LK, Whitaker DC. The impact of herbal medicines on dermatologic surgery. Dermatol Surg 2001;27:759-63.

Pribitkin ED, Boger G. Herbal therapy: What every facial plastic surgeon must know. Arch Facial Plast Surg 2001;3:127-32.

Heck AM, De Witt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7.

Shivakumar SI, Shahapurkar AA, Kalmath KV, Shivakumar B. Antiinflammatory activity of fruits of Cuminum cyminum Linn. Pharm Lett 2010;2:22-4.

Bameri Z, Amini-Boroujeni N, Saeidi S, Bazi S. Antimicrobial activity of Cyminum cuminum against biofilm E. coli. Int Res J Appl Basic Sci 2013;5:1232-4.

Willatgamuva SA, Platel K, Sarawathi G, Srinivasan K. Antidiabetic influence of dietary cumin seeds (Cuminum cyminum) in streptozotocin induced diabetic rats. Nutr Res 1998;18:131-42.

Allahghadri T, Rasooli I, Owlia P, Nadooshan MJ, Ghazanfari T, Taghizadeh M, et al. Antimicrobial property, antioxidant capacity, and cytotoxicity of essential oil from cumin produced in Iran. J Food Sci 2010;75:H54-61.

Vallverdú-Queralt A, Regueiro J, Martínez-Huélamo M, Alvarenga JF, Leal LN, Lamuela-Raventos RM. A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay. Food Chem 2014;154:299-307.

Bhat SP, Rizvi W, Kumar A. Effect of Cuminum cyminum L seed extracts on pain and inflammation. J Nat Remedies 2014;14:186-92.

Kalaivani P, Saranya RB, Ramakrishnan G, Ranju V, Sathiya S, Gayathri V, et al. Cuminum cyminum, a dietary spice, attenuates hypertension via endothelial nitric oxide synthase and NO pathway in renovascular hypertensive rats. Clin Exp Hypertens 2013;35:534-42.

Boskabady MH, Kiani S, Azizi H. Relaxant effect of Cuminum cyminum on guinea pig tracheal chains and its possible mechanism(s). Indian J Pharmacol 2005;37:111-5.

Parthasarathy VA, Chempakam B, Zachariah TJ. Chemistry of spices. CAB Int 2008;2008:211226.

Rai N, Yadav S, Verma AK, Tiwari L, Sharma RK. A monographic profile on quality specifications for a herbal drug and spice of commerce Cuminum cyminum L. Int J Adv Herb Sci Technol 2012;1:1-12.

Breu W. Allium cepa L. (onion) Part 1: Chemistry and analysis. Phytomedicine 1996;3:293-306.

Yoshinari O, Shiojima Y, Igarashi K. Angiosperm phylogeny group an update of the angiosperm phylogeny group classification for the orders and families of flowering plants: APG III. Bot J Linn Soc 2009;161:105-21.

Prakash D, Singh BN, Upadhyay G. Antioxidant and free radical scavenging activities of phenols from onion (Allium cepa) Food Chem 2007;102:1389-93.

Saba A, Zolfaghar R, Mehdi VM. Evaluation of the antiviral effects of aqueous extracts of red and yellow onions (Allium cepa) against avian influenza virus subtype H9N2. Iran J Vet Sci Technol 2018;2:1-11.

Neha S. Efficacy of Garlic and Onion against virus. J Res Pharm Sci 2019;10:3578-86.

Kendler BS. Garlic (Allium sativum) and onion (Allium cepa): A review of their relationship to cardiovascular disease. Prev Med 1987;16:670-85.

Akash MS, Rehman K, Chen S. Spice plant Allium cepa: Dietary supplement for treatment of Type 2 diabetes mellitus. Nutrition 2014;30:1128-37.

Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, et al. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: A randomised double-blinded placebo-controlled cross-over trial. Br J Nutr 2015;114:1263-77.

Published

01-07-2021

How to Cite

SUNDAY, R. M. (2021). ACCLAIMED MEDICINAL PLANTS USED FOR THE PREVENTION AND TREATMENT OF CORONAVIRUS DISEASE 2019: CONCERNS ON SAFETY LEVELS. Innovare Journal of Medical Sciences, 9(4), 9–11. https://doi.org/10.22159/ijms.2021.v9i4.41768

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Section

Review Article(s)