COMPUTATIONAL RESEARCH USING PHYTOCHEMICALS FROM THE ACACIA CAVEN PLANT TO COMBAT THE VP40-FUNCTIONALIZED EBOLA VIRUS ILLNESS

SHAMANTH KRISHNA

doi:10.22159/ijms.2022.v10i6.46620

Authors

SHAMANTH KRISHNA Department of Biotechnology, NMAM Institute of Technology, Karkala, Karnataka, India.

DOI:

https://doi.org/10.22159/ijms.2022.v10i6.46620

Keywords:

Ebola Virus, Acacia caven, VP40 protein, phytochemicals, drug-likeness

Abstract

Objectives: The Ebola virus is an extraordinarily deadly illness that affects both humans and wild animals. Key elements in viral proliferation include viral adhesion to cell membranes and viral penetration into the host organism. The viral protein present in the Ebola virus is the matrix protein Viral Protein-40 (VP-40) which is required for the development and integration of the nucleocapsid. Limiting VP40 activity prevents the viral infection from spreading.

Methods: Ten phytochemicals from Acacia caven were examined for their physicochemical properties, drug-likeness, and their potential to impede VP40 to assess their potential as anti-Ebola virus therapeutics.

Results: Considering the pharmacological uses, ten bioactive chemicals were chosen for this investigation. Predicated on their docking score and binding interactions, Pimara-8(14), 15-diene, Heptacosane, and Geranylacetone were recognized as VP-40 inhibitors.

Conclusion: Developing medicines that can inhibit VP40 could be a potential anti-Ebola virus treatment solution as VP40 is a fundamental protein for the assemblage of virion. Using the ligands Geranylacetone, Heptacosane, and Pimara-8(14), 15-diene, anti-Ebola virus therapeutics can be developed that specifically target the VP40 suppression which aids in the management of Ebola Virus disease.

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