PEDIATRIC ANTI-NMDA RECEPTOR ENCEPHALITIS: A CASE REPORT

Authors

  • ARMAND SHEHU Department of Pediatrics, Faculty of Medicine, University of Medicine, Tirana, Albania.
  • KRISTI ALEKSI Faculty of Medicine, University of Medicine, Tirana, Albania.
  • AFERDITA TAKO KUMARAKU Department of Pediatrics, Faculty of Medicine, University of Medicine, Tirana, Albania.
  • AIDA BUSHATI Department of Pediatrics, Faculty of Medicine, University of Medicine, Tirana, Albania.
  • ALBA JONUZI Service of Pediatrics, Mother Teresa University Hospital Center, Tirana, Albania.
  • LURJANA ASLLANAJ Service of Pediatrics, Mother Teresa University Hospital Center, Tirana, Albania.

DOI:

https://doi.org/10.22159/ijms.2023.v11i1.47041

Keywords:

autoimmune encephalitis, post-infectious encephalitis, anti-NMDAR encephalitis, pediatrics

Abstract

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune inflammation of the brain parenchyma mediated with autoantibodies against the NMDA receptors in the neuronal cells. It is the most common form of autoimmune encephalitides in pediatric patients. In this case report, we present the case of a child with anti-NMDAR encephalitis, refractory to the first-line therapy.

References

Mori H, Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 1995;34:1219-37.

Li F, Tsien JZ. Memory and the NMDA receptors. N Engl J Med 2009;361:302-3.

Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011;10:63-74.

Hermetter C, Fazekas F, Hochmeister S. Systematic review: Syndromes, early diagnosis, and treatment in autoimmune encephalitis. Front Neurol 2018;9:706.

Armangue T, Spatola M, Vlagea A, Mattozzi S, Cárceles-Cordon M, Martinez-Heras E, et al. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: A prospective observational study and retrospective analysis. Lancet Neurol 2018;17:760-2.

Barbagallo M, Vitaliti G, Pavone P, Romano C, Lubrano R, Falsaperla R. Pediatric autoimmune encephalitis. J Pediatr Neurosci 2017;12:130-4.

Sanchez CV, Theel E, Binnicker M, Toledano M, McKeon A. Autoimmune encephalitis after SARS-CoV-2 infection: Case frequency, findings, and outcomes. Neurolology 2021;97:e2262-8.

Nosadini M, Thomas T, Eyre M, Anlar B, Armangue T, Benseler SM, et al. International consensus recommendations for the treatment of pediatric NMDAR antibody encephalitis. Neurol Neuroimmunol Neuroinflamm 2021;8:e1052.

Published

01-01-2023

How to Cite

SHEHU, A., ALEKSI, K., KUMARAKU, A. T., BUSHATI, A., JONUZI, A., & ASLLANAJ, L. (2023). PEDIATRIC ANTI-NMDA RECEPTOR ENCEPHALITIS: A CASE REPORT. Innovare Journal of Medical Sciences, 11(1), 1–2. https://doi.org/10.22159/ijms.2023.v11i1.47041

Issue

Vol 11 Issue 1 2023 (Jan - Feb)

Section

Case Study(s) / Case Report (s)

Copyright (c) 2023 Kristi Aleksi

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC