NUTRACEUTICALS: USING COMMON FOODS TO IMPROVE HEALTH, PREVENTING ILLNESS, AND ADDRESS SAFETY ISSUES

Authors

  • JONNY KUMAR SHARMA Department of Pharmaceutics, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • VIKAS SHARMA Department of Pharmaceutics, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • DHEERAJ SHARMA Department of Pharmaceutics, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • MOHAMMAD ASIF Department of Pharmaceutics, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ijms.2023.v11i1.47172

Keywords:

Anti-Inflammatory, Antioxidant, Anti-Cancer, Anti-Inflammation, Anti-Lipid, Safety, Toxicity of Nutraceuticals

Abstract

Important dietary components known as nutraceuticals have both therapeutic and nutritional impacts. The active ingredients in these foods, including such carotenoids, collagen hydrolysate, and dietary fibers, are what provide them their health benefits. Nutraceuticals have been shown to have a good impact on immunological and cardiovascular health, as well as play a part in the prevention of infections and cancer. Depending on its nature and manner of action, nutraceuticals can be divided into many types. Various nutraceutical categories and their therapeutic potential effects, including anti-cancer, antioxidant, anti-inflammatory, and anti-lipid activity in disease, will be examined in this study. In addition, the many ways in which these accepted methods and structures, their application, and human safety would be covered, along with recent trends and nutraceuticals’ potential for the development.

References

Misra L. Traditional phytomedicinal systems, scientific validations and current popularity as nutraceuticals. Int J Trad Nat Med 2013;2:27-75.

Petrovska BB. Historical review of medicinal plants’ usage. Pharmacogn Rev 2012;6:1-5.

AlAli M, Alqubaisy M, Aljaafari MN, AlAli AO, Baqais L, Molouki A, et al. Nutraceuticals: Transformation of conventional foods into health promoters/disease preventers and safety considerations. Molecules 2021;26:2540.

Malago JJ, Koninkx JF, Marinsek-Logar R. Probiotic Bacteria and Enteric Infections. Cytoprotection by Probiotic Bacteria. Available from: https://www.springer.com/978-94-007-0385 [Last accessed on 2011 Dec 04].

Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: An updated meta-analysis and review. J Nutr 2016;146:389S-96.

Pitchaiah G, Akula A, Chandi V. Anticancer potential of nutraceutical formulations in MNU-induced mammary cancer in Sprague Dawley rats. Pharmacogn Mag 2017;13:46-50.

Affuso F, Ruvolo A, Micillo F, Saccà L, Fazio S. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr Metab Cardiovasc Dis 2010;20:656-61.

Caramia G, Silvi S. Probiotics: From the Ancient Wisdom to the Actual Therapeutical and Nutraceutical Perspective. Probiotic Bacteria and Enteric Infections. Dordrecht: Springer; 2011. p. 3-37.

Scrinis G. Functional foods or functionally marketed foods? A critique of, and alternatives to, the category of functional foods. Public Health Nutr 2008;11:541-5.

Singh J, Sinha S. Classification, regulatory acts and applications of nutraceuticals for health. Int J Pharma Bio Sci 2012;2:177-87.

Bhowmik D, Kumar KS, Paswan S, Srivastava S. Tomato-a natural medicine and its health benefits. J Pharmacogn Phytochem 2012;1:33-43.

Singh B, Singh JP, Singh N, Kaur A. Saponins in pulses and their health promoting activities: A review. Food Chem 2017;233:540-9.

Bhat FM, Riar CS. Health benefits of traditional rice varieties of temperate regions. Med Aromat Plants 2015;4:198.

Shardell MD, Alley DE, Hicks GE, El-Kamary SS, Miller RR, Semba RD, et al. Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: The third national health and nutrition examination survey. Nutr Res 2011;31:178-89.

El Sohaimy SA. Functional foods and nutraceuticals-modern approach to food science. World Appl Sci J 2012;20:691-708.

Prueckler M, Siebenhandl-Ehn S, Apprich S, Hoeltinger S, Haas C, Schmid E, et al. Wheat bran-based biorefinery 1: Composition of wheat bran and strategies of functionalization. LWT Food Sci Technol 2014;56:211-21.

Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: A systematic review of the literature. Am J Gastroenterol 2011;106:563-73.

Umadevi M, Pushpa R, Sampathkumar KP, Bhowmik D. Rice-traditional medicinal plant in India. J Pharmacogn Phytochem 2012;1:6-12.

Turner ND, Lupton JR. Dietary fiber. Adv Nutr 2011;2:151-2.

Zeng H, Lazarova DL, Bordonaro M. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J Gastrointest Oncol 2014;6:41-51.

Kim DU, Chung HC, Choi J, Sakai, Y, Boo-Yong L. Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients 2018;10:826.

Gómez-Guillén MC, Giménez B, López-Caballero MA, Montero MP. Functional and bioactive properties of collagen and gelatin from alternative sources: A review. Food Hydrocoll 2011;25:1813-27.

Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D, Gyftopoulou K, Skarmoutsou N, et al. Health benefits of probiotics: A review. ISRN Nutr 2013;2013:481651.

Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4:118-26.

Caetano BF, De Moura NA, Almeida AP, Dias MC, Sivieri K, Barbisan LF. Yacon (Smallanthus sonchifolius) as a food supplement: Health-promoting benefits of fructooligosaccharides. Nutrients 2016;8:436.

Kumar GP, Khanum F. Neuroprotective potential of phytochemicals. Pharmacogn Rev 2012;6:81-90.

Gupta S, Chauhan D, Mehla K, Sood P, Nair A. An overview of nutraceuticals: Current scenario. J Basic Clin Pharm 2010;1:55-62.

Roadjanakamolson M, Suntornsuk W. Production of beta-carotene-enriched rice bran using solid-state fermentation of Rhodotorula glutinis. J Microbiol Biotechnol 2010;20:525-31.

Kalra EK. Nutraceutical-definition and introduction. AAPS Pharmsci 2003;5:E25.

Sui X, Zhang Y, Zhou W. Bread fortified with anthocyanin-rich extract from black rice as nutraceutical sources: Its quality attributes and in vitro digestibility. Food Chem 2016;196:910-6.

Skinner MA, Loh JM, Hunter DC, Zhang J. Gold kiwifruit (Actinidia chinensis ‘Hort16A’) for immune support. Proceed Nutr Soc 2011;70:276-80.

Imam SS. The future of non-invasive ways to treat cancer. Int J Pharm Sci Res 2021;12:4684-96.

De Mejia EG, Dia VP. The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells. Cancer Metastasis Rev 2010;29:511-28.

Vuolo L, Di Somma C, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol (Lausanne) 2012;3:58.

Altieri B, Di Dato C, Modica R, Bottiglieri F, Di Sarno A, Pittaway JF, et al. Bone metabolism and Vitamin D implication in gastroenteropancreatic neuroendocrine tumors. Nutrients 2020;12:1021.

Imam SS, Agarwal S. A Pragmatic approach to treat lung cancer through loading theaflavin-3,3-digallate and epigallocatechin gallate in spanlastic. Asian J Pharm Clin Res 2021;14:1-8.

Imam SS, Imam ST, Mdwasifathar, Kumar R, Ammar MY. Interaction between ace 2 and SARS-COV2, and use of egcg and theaflavin to treat Covid 19 in initial phases. Int J Curr Pharm Res 2022;14:5-10.

Raman M, Ambalam P, Kondepudi KK, Pithva S, Kothari C, Patel AT, et al. Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer. Gut Microbes 2013;4:181-92.

Imam SS, Imam ST, Agarwal S, Kumar R, Ammar MY, Athar MW, et al. Lung cancer therapy using naturally occurring products and nanotechnology. Innovare J Med Sci 2022;10:1-5.

Sharma S, Kumari D, Khan S, Pathak P, Katiyar D, Imam SS. An expedient approach to treat asthma through non-steroidal, natural transferosomes aerosol system. Innovare J Med Sci 2022;10:7-11.

Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR, Vetrichelvi V. Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Mol Cell Biochem 2012;369:17-25.

Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL, et al. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: Results of a randomised, double-blind, placebo-controlled trial. Br J Nutr 2012;108:1272-9.

Liu X, Wu Y, Li F, Zhang D. Dietary fiber intake reduces risk of inflammatory bowel disease: Result from a meta-analysis. Nutr Res 2015;35:753-8.

Bolling BW, Chen CY, McKay DL, Blumberg JB. Tree nut phytochemicals: composition, antioxidant capacity, bioactivity, impact factors. A systematic review of almonds, Brazils, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts. Nutr Res Rev 2011;24:244-75.

Biagi M, Minoretti P, Bertona M, Emanuele E. Effects of a nutraceutical combination of fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia: An 8-week, open-label, single-arm pilot study. Arch Med Sci Atheroscler Dis 2018;3:e137-41.

Surampudi P, Enkhmaa B, Anuurad E, Berglund L. Lipid lowering with soluble dietary fiber. Curr Atheroscler Rep 2016;18:75.

Bulló M, Juanola-Falgarona M, Hernández-Alonso P, Salas-Salvadó J. Nutrition attributes and health effects of pistachio nuts. Br J Nutr 2015;113:S79-93.

Houston MC. Treatment of hypertension with nutraceuticals, vitamins, antioxidants and minerals. Exp Rev Cardiovasc Ther 2007;5:681-91.

Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuca K. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: An overview. Arch Toxicol 2016;90:1817-40.

McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Yang LV, Murata RM, et al. Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging (Albany NY) 2017;9:1477-536.

Srinivasan K. Antioxidant potential of spices and their active constituents. Crit Rev Food Sci Nutr 2014;54:352-72.

Tesoriere L, Allegra M, Butera D, Livrea MA. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: Potential health effects of betalains in humans. Am J Clin Nutr 2004;80:941-5.

Danwilai K, Konmun J, Sripanidkulchai BO, Subongkot S. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: A pilot study. Cancer Manag Res 2017;9:11-8.

Kim M, Kim Y. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr Res Pract 2010;4:191-5.

Gul K, Singh AK, Jabeen R. Nutraceuticals and functional foods: The foods for the future world. Crit Rev Food Sci Nutr 2016;56:2617-27.

Gupta RC, Lall R, Srivastava A, editors. Nutraceuticals: Efficacy, Safety and Toxicity. Cambridge: Academic Press; 2021.

Ayaz M, Ullah F, Sadiq A, Ullah F, Ovais M, Ahmed J, et al. Synergistic interactions of phytochemicals with antimicrobial agents: Potential strategy to counteract drug resistance. Chem Biol Interact 2019;308:294-303.

Sehgal I, Winters WD, Scott M, Kousoulas K. An in vitro and in vivo toxicologic evaluation of a stabilized aloe vera gel supplement drink in mice. Food Chem Toxicol 2013;55:363-70.

Published

01-01-2023

How to Cite

SHARMA, J. K., SHARMA, V., SHARMA, D., & ASIF, M. (2023). NUTRACEUTICALS: USING COMMON FOODS TO IMPROVE HEALTH, PREVENTING ILLNESS, AND ADDRESS SAFETY ISSUES. Innovare Journal of Medical Sciences, 11(1), 3–8. https://doi.org/10.22159/ijms.2023.v11i1.47172

Issue

Section

Review Article(s)