CHIKUNGUNYA, SCRUB TYPHUS MONO, AND CO-INFECTION AMONG PATIENTS WITH UNDIFFERENTIATED FEBRILE ILLNESS: A HOSPITAL-BASED STUDY

Authors

  • Pratiti Datta Department of Microbiology, VRDL, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.
  • Subhenjit Roy Department of Microbiology, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.
  • TK MANDAL Department of Microbiology, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.
  • Piyali Haldar Department of Microbiology, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.
  • Utpal Dan Department of Anatomy, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.
  • Santanu Saha Department of General Medicine, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.
  • Sumantra Sarkar Department of Paediatric Medicine, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

DOI:

https://doi.org/10.22159/ijms.2023.v11i3.48049

Keywords:

Chikungunya, Scrub typhus, Coinfection, Enzyme-linked immunosorbent assay

Abstract

Objectives: Chikungunya virus is a common arthropod-related acute febrile disease and it is transmitted by Aedes aegypti or Aedes albopictus species. On the other hand, the bacterium Orientia tsutsugamushi causes scrub typhus, which is also an acute febrile illness with multiple organ involvement. Coinfection of chikungunya and scrub typhus may lead to severe manifestation including severe respiratory and central nervous system (CNS) complications. Coinfection of chikungunya and scrub typhus may lead to severe manifestation including severe respiratory and CNS complications. Therefore, the proper diagnosis can prevent the clinical complications. The aim and objective of our study is to find the seroprevalence of chikungunya and scrub typhus and coinfection of both through medical assessment and serological research of these patients presented with acute febrile infection at Diamond Harbour Government Medical College and Hospital.

Methods: A prospective study was conducted from August 2022 to January 2023 at VRDL, Department of Microbiology, Diamond Harbour Government Medical College and Hospital. Serum was collected for IgM antibody enzyme-linked immunosorbent assay (ELISA) for scrub typhus (In bios kit) and Chikungunya (NIV Chikungunya IgM Capture ELISA Kit) test. Four hundred and eighty-seven samples were tested for IgM antibody by chikungunya and scrub typhus ELISA kit.

Result: The present study demonstrated that, from the month of August 2022 to January 2023, 67% of chikungunya cases, 25% cases with only scrub typhus, and 8% cases with both chikungunya and scrub typhus presented positive. A present study shows that chikungunya is slightly more prevalent in males as compared to females, where scrub typhus is equally positive in both male and female patients.

Conclusion: Laboratory testing of both of the diseases can prevent the complication of other suspected disease in coinfected patients.

Author Biographies

Pratiti Datta, Department of Microbiology, VRDL, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

Scientist B, VRDL, Diamond Harbour Govt MCH

Subhenjit Roy, Department of Microbiology, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

(Demonstrator, Department of Microbiology, Diamond Harbour Govt MCH.

TK MANDAL, Department of Microbiology, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

(Assistant Professor , Department of Microbiology,Diamond Harbour Govt MCH

Piyali Haldar, Department of Microbiology, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

Demonstrator, Department of Microbiology, Diamond Harbour Govt MCH.

Utpal Dan, Department of Anatomy, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

Principal

Diamond Harbour Govt MCH

Santanu Saha, Department of General Medicine, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

(Professor and Head, Department of General Medicine, Diamond Harbour Govt MCH.)

Sumantra Sarkar, Department of Paediatric Medicine, Diamond Harbour Government MCH, Diamond Harbour, West Bengal, India.

(Professor and Head, Department of Paediatric Medicine, Diamond Harbour Govt MCH.)

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Published

01-05-2023

How to Cite

Datta, P., Roy, S., MANDAL, T., Haldar, P., Dan, U., Saha, S., & Sarkar, S. (2023). CHIKUNGUNYA, SCRUB TYPHUS MONO, AND CO-INFECTION AMONG PATIENTS WITH UNDIFFERENTIATED FEBRILE ILLNESS: A HOSPITAL-BASED STUDY. Innovare Journal of Medical Sciences, 11(3), 1–4. https://doi.org/10.22159/ijms.2023.v11i3.48049

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Section

Original Article(s)