STUDIES ON SIDA ACUTA HYDROGEL I: PROCESSING AND PHYSICOCHEMICAL PROPERTIES OF THE DERIVED HYDROGEL OBTAINED FROM SOUTH EAST NIGERIA
DOI:
https://doi.org/10.22159/ijpps.2017v9i6.10097Keywords:
Sida acuta hydrogel, Processing, Physicochemical properties, South East NigeriaAbstract
Objective: Sida acuta is a plant that is widely distributed in the subtropical regions where it is found in bushes, in farms and around habitations. This study was carried out to isolate hydrogel from this freely available natural source.
Methods: The sieved dried powder from the leaves of Sida acuta was macerated in distilled water. The mucilage formed was filtered and precipitated with equal volumes of isopropyl alcohol. This was repeated using ethanol and acetone respectively. The precipitated hydrogel was purified by washing twice with isopropyl alcohol, once with acetone and dried in the oven at 40 °C for 8h.
Results: The mean percentage yield of the hydrogel as obtained was 10.15±1.22, 9.24±0.74 and 7.90±0.03 %w/w for isopropyl alcohol, ethanol and acetone precipitated hydrogels respectively. The swelling index of the hydrogel in water was 10.00±0.02. The solubility of the hydrogel in water at 28 °C and 80 °C were 7.00±0.41 and 8.63±0.63 respectively. The solubility of the hydrogel in 0.1 N NaOH and 0.1 N HCl solutions were 11.86±1.75 and 5.67±0.58 mg/ml respectively. The loss on drying was 14 5±1.87% while total ash was 53.33±5.77 mg per 1 g hydrogel. The viscosity of a 1%w/v solution of the hydrogel using rotor 1 of a Brookfield viscometer at 30 rpm was 71.4±0.00 mPas. The pH of a 1%w/v solution was 6.60±009. The Carr's index and Hausner ratio were 38.77±1.69% and 1.63±0.05 respectively.
Conclusion: The hydrogel obtained from powdered dried leaves of Sida acuta may have potential in various drug delivery systems.
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