ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF ORMOCARPUM SENNOIDES
Keywords:
Anti-inflammatory activity, Anti-arthritic activity, Ormocarpum sennoides, Rheumatoid arthritisAbstract
Objective: The study focuses on evaluating the anti-inflammatory and anti-arthritic activity of ethanolic extract of Ormocarpum sennoides (Os), a herb belonging to the family fabaceae. Both in vitro and in vivo methods were employed to study the anti-inflammatory activity of Os extract.
Methods: The in vitro analysis of Os extract was performed by HRBC membrane stabilization and protein denaturation methods. The in vivo analysis was done by Formalin-induced paw edema and acetic acid induced writhing test using wistar male albino rats as an animal model.
Results: The in vitro analysis revealed the inhibition of hemolysis and protein denaturation in a dose-dependent manner in concentrations ranging from 50-500 µg/ml. The in vivo study showed that Os extract reduced the number of paw lickings and abdominal writhing significantly at dosage concentrations of 200 mg/kg body weight and 300 mg/kg body weight compared with standard diclofenac sodium (p<0.05).
Conclusion: These results support the application of Os extract in ailing arthritis and treatment of painful inflammatory conditions.
Keywords: Anti-inflammatory activity, Anti-arthritic activity, Ormocarpum sennoides, Rheumatoid arthritis
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References
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