SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-HYDRAZONO-2(3H)-THIAZOLE DERIVATIVES DERIVED FROM 4-(3-CHLOROPHENYL)-3-THIOSEMICARBAZIDE
Abstract
Objective: A series of substituted 2-hydrazono-2(3H)-thiazole derivatives were synthesized from 4-(3-chlorophenyl)-3-thiosemicarbazide and evaluated in vitro for antimicrobial activity against Escherichia coli, Candida albicans, Pseudomonas aeruginosa, Bacillus subtilis and Staphyllococcus aureus.
Methods: 4-(3-Chlorophenyl)-3-thiosemicarbazones were synthesized and allowed to react with 2,4′-dibromoacetophenone to give 2-hydrazono-2(3H)-thiazoles in excellent yields. The synthesized compounds were characterized by spectroscopic methods as well as elemental analyses. They were screened for their antimicrobial activity by using the agar diffusion method.
Results: The antimicrobial data suggested that all compounds showed significant activity against E. coli and C. albicans compared to the standard drug. Only 7b and 7d exhibited moderate activity against P. aeruginosa.
Conclusion: Compounds bearing a substituted phenyl or indolyl group at the hydrazone moiety have considerable antimicrobial activity than those with a cycloalkyl group.
Keywords: 2,3-Dihydrothiazole, 4-(3-Chlorophenyl)-3-thiosemicarbazide, Antimicrobial activity
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References
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