OXIDANTS AND ANTIOXIDANTS AS RISK FACTORS IN YOUNG ARABIAN MALE PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Keywords:
Acute myocardial infarction, xanthine Oxidase, Malondialdehyde, antioxidants, Lipid profileAbstract
Objective: This study aim to investigate the levels of oxidative stress, antioxidants besides uric acid, C-reactive protein (CRP), lipid profile and cardiac biomarker enzymes in young men admitted to the hospital for the first time with acute myocardial infarction (AMI), to investigate any Relationship between them.
Methods: 135 young men age Ë‚ 40 y old, admitted to the cardiology unit with suspected MI and 130 age and sex matched healthy controls were included in this study. Blood samples were collected from the patients and the control group. The blood samples were collected from the patients on the day of admission and on the day of discharge.
Results: The levels of xanthine oxidase (XO), malondialdehyde (MDA), CRP, uric acid, total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL-C), apoprotein-B 100 (Apo B), and cardiac biomarker enzymes were significantly high, whereas catalase, vitamin C, high-density lipoprotein (HDL-C) and apoprotein-A1 (Apo A1) were significantly low on the day of admission (Time A) and slightly higher on the day of discharge (Time B), but both were still lower than the controls. There was a decrease in XO and MDA activity and an increase in catalase activity and vitamin C level.
Conclusion: These results may indicate possible relationships between these parameters and AMI.
Keywords: Acute myocardial infarction, Xanthine oxidase, Malondialdehyde, Antioxidants, Lipid profile
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