STABILITY OF FLOATING MICROSPHERES AT NORMAL AND ACCELERATED CONDITIONS

Authors

  • Megha Sharma Shri Ram Institute of Technology (Pharmacy), Near ITI, Madhotal, Jabalpur (M.P.)
  • Seema Kohli
  • Abhisek Pal

Keywords:

Stability, microspheres, buoyancy, physical, freezing

Abstract

Objective: To study the stability profile of floating microspheres of repaglinide as per ICH guidelines under normal (25±2°C/60±5% RH) and accelerated condition (40±2°C/75±5% RH and 5-8°C/65±5% RH) for a period of six mo.

Methods: Floating microspheres were prepared using ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMC) and subjected to stability studies. Physical appearance, scanning electron microscopy (SEM), % buoyancy, % residual drug content and drug release of stored formulation were evaluated after every two mo.

Results: Change in color, size, and residual drug content showed no significant variations in formulations stored at a different set of conditions. SEM images showed no morphological transformation during the study. Less than 5% change was observed in buoyancy and drug release.

Conclusion: The data depict that the formulation is sufficiently rugged for marketing worldwide under various climatic conditions including normal, oven and freezing temperature.

Keywords: Stability, Microspheres, Buoyancy, Physical, Freezing

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Published

01-07-2016

How to Cite

Sharma, M., S. Kohli, and A. Pal. “STABILITY OF FLOATING MICROSPHERES AT NORMAL AND ACCELERATED CONDITIONS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 7, July 2016, pp. 452-4, https://journals.innovareacademics.in/index.php/ijpps/article/view/11959.

Issue

Section

Short Communication(s)