DEVELOPMENT OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM FOR NATEGLINIDE AN ANTI-DIABETIC DRUG

Authors

  • Sailaja Reddy Karri J.S.S College of Pharmacy (A Constituent College of JSS University, Mysore), Udhagamandalam, Tamilnadu, India.
  • V. V. S. Narayana Reddy K. J.S.S College of Pharmacy (A Constituent College of JSS University, Mysore), Udhagamandalam, Tamilnadu, India.
  • Kollipara Radhakrishna J.S.S College of Pharmacy (A Constituent College of JSS University, Mysore), Udhagamandalam, Tamilnadu, India.
  • G. N. K. Ganesh J.S.S College of Pharmacy (A Constituent College of JSS University, Mysore), Udhagamandalam, Tamilnadu, India.

Keywords:

Controlled release, Push-pull osmotic pump, Nateglinide

Abstract

  1. Objective: The purpose of the present study was to develop an oral push-pull osmotic drug delivery system for the drug Nateglinide which is a bio pharmaceutics classification system (BCS) class II drug. 
  2. Methods: The tablets were prepared by the wet granulation method using ingredients microcrystalline cellulose (Adsorbent), potassium chloride (Osmotic agent), poly ethylene glycol (4000 and 6000) (Hydrophilic polymer, Plasticizer), starch (Disintegrant), and aerosil. The granules were compacted by double compression method and were coated with eudragit by dipping method. Different batches were prepared to study the effect of the various ingredients and their effect on the release of the drug from the system by varying the concentrations of the ingredients in each batch. Dissolution was assessed using USP dissolution apparatus 2 in phosphate buffer pH 6.8 for 12 h. 
  3. Results: Certain key findings observed includes a decrease in micro crystalline cellulose content reduced the release of the drug due to the reduction of the hydrophilic content in the tablet which complements the uptake of water from the surroundings, and increase in the ethylene glycol leads to decrease in the release which resulted due to excess swelling and increase in the osmotic agent concentration lead to satisfactory release of the drug and followed zero-order release. 
  4. Conclusion: To conclude, the push-pull osmotic tablet of Nateglinide was able to deliver the drug in a controlled pattern for a prolonged period of time. This type of formulation can be used in conditions like hyperglycemia where the patient compliance can improve by reducing the dosing frequency and the plasma drug levels can be maintained, the total drug load is also reduced so that the dose related side-effects are also reduced. 
  5. Keywords: Controlled release, Push-pull osmotic pump, Nateglinide

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References

Speers M, Bonnano C. Economic aspects of controlled drug delivery. In: Mathiowitz E, editor. Encyclopedia of Controlled Drug Delivery. New York, NY: Wiley;1999. p. 341–347

Verma RK, Mishra B, Garg S. Osmotically controlled oral drug delivery. Drug Dev Ind Pharm 2000;26:695–708.

Tanmoy G, Amitava G. Drug delivery through osmotic systems an overview. J App Pharm Sci 2011;01:38-49.

Parmar NS, Vyas SK, Vaya N. Osmotic pump-a novel drug delivery system. In: Jain [KN] Advanced in controlled and novel drug delivery. 1st ed. New Delhi: CBS publishers and distributors; 2001.18-39.

Bhatt P Padmanabh. Osmotic drug delivery system for poorly soluble drug. Pharma venture Ltd(2004).

Rajan KV, Murali Krishna D, Sanjay G. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J Control Release 2002;79:7–27.

Kunal NP, Tejal AM. A review on oral osmotically driven systems.int j pharm pharm sci 2013;5:1005-13.

Verma RK, Garg S. Current status of drug delivery technologies and future directions. Pharm Technol 2001;25:1–14.

Gadwal P, Rudrawal P, Ahamad D, Ahmed A. A review on osmotically regulated devices. Int j pharm life sci 2010;1:302-12

Kumar P, Singh S, Mishra B. Development and Evaluation of Elementary Osmotic Pump of Highly Water Soluble Drug: Tramadol Hydrochloride. Current Drug Delivery 2009;6 :130-39.

Theeuwes F. Elementary osmotic pump. J Pharm Sci 1975;64:1987–91.

Theeuwes F, Swanson DR, Guittard G, Ayer A, Khanna S. Osmotic delivery systems for the Beta adrenoceptor antagonists metoprolol and oxprenolol: design and evaluation of systems for once-daily administration. Br J Clin Pharmacol 1985;19: 69–76.

Jamzad S, Fassihi R. Development of a controlled release low dose class II drug-Glipizide. Int J Pharm 2006;312:24–32.

Zhang Z, Dong H, Peng B, Liu H, Li C, Liang M, Pan W. Design of an expert system for the development and formulation of push–pull osmotic pump tablets containing poorly water-soluble drugs. Int J Pharm 2011;410:41–47.

Prabakaran D, Singh P, Jaganathan KS, Vyas SP. (b) Osmotically regulated asymmetric capsular systems for simultaneous sustained delivery of anti tubercular drugs. J Control Rel 2004;95:239–48.

Prabakaran D, Singh P, Kanaujia PK, Mishra V, Jaganathan KS, Vyas SP.(a) Osmotically regulated asymmetric capsular systems for simultaneous sustained delivery of anti tubercular drugs. J Control Rel 2004; 95:239–48.

Dehghan MHG, Kazi MS, Ansari MA. Formulation and evaluation of once daily osmotic tablet of ketoprofen. Int j pharm pharm sci 2014; 6:2951-57

Panchaxari MD, Chirag prakashbhai P, Rohit S, Anand panchakshari G, Vinayak M. Studies on formulation and evaluation of osmotically controlled drug delivery system of carbamazepine. Int j pharm pharm sci 2014; 6:2239-50.

Prabakaran D, Singh P, Kanaujia P, Vyas SP. Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps. Int J Pharm 2003;259:173–9

Liu LKu J, Khang GK, Lee B, Rhee JM, Lee HB. Nifedipine controlled delivery by sandwiched osmotic tablet system. J Control Rel 2000;68:145–56

Ritesh B, Patel HR, Patel GN, Patel RP, Patel M. Development of osmotically controlled drug delivery system by inclusion complex with HP-β-CD of glipizide: optimization of formulation using response surface methodology. Asian J Pharm 2010;5:74-86

Campbell K, Craig DQ, Mc Nally T. Polyethylene glycol layered silicate nano composites for retarded drug release prepared by hot-melt extrusion. Int J Pharm 2008; 363:126–31.

Monika K, Rahul K. Formulation and evaluation of osmotic pump tablet of cefadroxil. Int j pharm pharm sci 2013;5:114-8.

Liu L, Khang G, Rhee JM, Lee HB. Monolithic osmotic tablet system for nifedipine delivery. J Controlled Release 2000;67:309–22.

Durig T, Fassihi R. An investigation into the erosion behavior of a high drug-load (85%) particulate system designed for an extended-release matrix tablet. Analysis of erosion kinetics in conjunction with variations in lubrication, porosity, and compaction rate. J Pharm Pharmacol 1999;51:1085–92

Moore JW, Flanner H. Mathematical comparison of dissolution profiles. Pharm Technol 1996;20:64–74.

Costa P, Lobo MS. Modelling and comparison of dissolution profiles. Eur J Pharm. Sci 2001; 12:123-33

Published

01-07-2014

How to Cite

Karri, S. R., V. V. S. N. Reddy K., K. Radhakrishna, and G. N. K. Ganesh. “DEVELOPMENT OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM FOR NATEGLINIDE AN ANTI-DIABETIC DRUG”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 120-5, https://journals.innovareacademics.in/index.php/ijpps/article/view/1292.

Issue

Vol 6, Issue 7, 2014

Section

Original Article(s)