FORMULATION AND EVALUATAION OF COLON TARGETED MATRIX TABLET OF NAPROXEN

Authors

  • JAIN H. N. Sigma Institute of Pharmacy, Baroda, 390019, India
  • PATEL K. R. Sigma Institute of Pharmacy, Baroda, 390019, India
  • KANZARIYA V. R. Sigma Institute of Pharmacy, Baroda, 390019, India
  • SHAH H. N. Sigma Institute of Pharmacy, Baroda, 390019, India
  • UPADHYAY U. M. Sigma Institute of Pharmacy, Baroda, 390019, India

Keywords:

Colon targeted drug delivery, Naproxen, Chronopharmaceutical drug delivery, Rheumatiod arthritis, Xanthan gum, Chitosan

Abstract

Objectives: The objective of the present study is to formulate the Colon targeted delivery containing Naproxen for chronopharmaceutical drug delivery system (ChrDDS) for treatment of rheumatoid arthritis, which are influenced by circadian rhythm. Chronopharmaceutical drug delivery system is capable of delivering drug when and where drug required most. Naproxen would remain in the GIT Fluid, intestinal fluid and it will liberate only in colonic fluid and gives better absorption.

Methods: The matrix core tablets of Naproxen were prepared by direct compression method by using Crosspovidone as superdisintegrant. From those optimesd batch core tablet is further going for coating. Coating was carried out by using natural gums like Xanthan gum, Guar gum, Chitosan and Pectin alone and in combination.

Results: From the experimental work Crosspovidone shows good drug release. Coating done by combination of Xanthan Gum and Chitosan shows better drug release (98.24%) in sustained release manner than other natural gums like Guar gum and pectin.

Conclusion: From the results obtained, it was concluded that the programmable Chronopharmaceutical drug release has been achieved from Crosspovidone containing core tablet compressed coated by combination of Xanthan gum and Chitosan over a 10 hrs period, consistent with the demands of chronotherapeutic drug delivery for rheumatoid arthritis.

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Author Biography

JAIN H. N., Sigma Institute of Pharmacy, Baroda, 390019, India

PHARMACEUTICS

References

Jain NK, Controlled and novel drug delivery, 1st Ed. CBS Publishers;New Delhi:2002. p. 340.

Verma S, Vipin Kumar, Mishra DN, Singh SK. colon targeted drug delivery:current and novel perspectivesâ€. Int J Pharm Sci and Res 2012;1274-84.

www.nras.org.uk/about_rheumatiodarthritis/managing_the pain_of_rhematoid arthritis. Accessed on 15th Oct 2013.

Sajan J, Cinu TA, Chacko AJ, Jaseeda T, Tropical J. Chronotherapeutics and Chronotherapeutic drug delivery system. J Pharm Rea 2009;8(5):467-75.

Dev RK, Bali V, Pathak K. Novel microbially triggered colon specific delivery system of 5-Fluorouracil:statistical optimization, in vitro, in vivo, cytotoxic and stability assessment. Int J Pharm 2011;411(1-2):142-51.

Krishnaith YSR, Satyanarayana V, Kumar BD. In vivo pharmacokinetics in human volunteers:oral administered guar gum based colon targeted 5-fluorouracil tabletsâ€. Euro J Pharmaceut Biopharm Acta Bio-Medica Atenei Parmensis 2003;19:355-62.

Sinha VR, Mittal BR, Kumria R. In vivo evaluation of time and site of disintegration of polysaccharide tablet prepared for colon-specific drug delivery. Int J Pharm 2005;289(1-2):79-85.

www.wikipedia.free encyclopedia://naproxen. J Acta Bio-Medica:Atenei Parmensis 2013.

Fumiyoshi Y, Mitsuru H, Pharmacokinetics consideration for targeted drug delivery.†J Adv Drug Delivery rev 2013;65:139-47.

Chickpetty SM, Basawaraj R, Kulkarni RV. Natural polysaccharides based compression coated tablets for colon targeted delivery of naproxen for the treatmetn of colitisâ€, Der Pharmamacia Lettre. J Acta Bio-Medica:Atenei Parmensis 2010;2(6):114-23.

Kumar S, Bhargava A, Asian J. Formulation and Evaluation Compressed Coat Tablets of Naproxen for Colon Targetingâ€. Biomed Pharmaceut Sci 2012:33-7.

Joao EC, Calvet GA, Krauss MR, Freimanis Hance L, Ortiz J, Ivalo SA, et al. Maternal antiretroviral use during pregnancy and infant congenital anomalies:the NISDI perinatal study. J Acquired Immune Defic Syndr 2010;53(2):176-85.

Sayeh FA, Jyrki H, Graffner C. Infuence of neutron activation Factors on matrix tablets for site specific delivery to colon. Euro J of Pharm Sci 2000;10:225-35.

Kishori LD, Nilima AT, Parag SG. Formulation and development of tinidazole microspheres for colon targeted drug delivery system. J of Pharmacy Res 2013;6:158-65.

Ramasamy T, Kandhasami US, Ruttala H. Formulation and Evaluation of xanthan gum based aceclofenac tablets for colon targeted drug deliveryâ€. Brazillian J of Pharm Sci 2011;47:89-108.

Patel JK, Patel NV, Shah SH. Formulation and in-vitro mevaluation of mesalamine matrix tablets using Chitosan for colonic drug delivery. J of Pharmacy Res 2009:1319-2.

Kabra AO, Zavare SS, Wanare RS. hydrophilic polymers in formulation of sustained release coated matrix tablets of 5-amino salicylic acid for targeting colon. Int J of Res Pharm and Biomedical Sci 2011;2:224-30.

R. Uma devi, preparation and characterization of pectin pellets of aceclofenac for colon targeted deliveryâ€. J of Chemical and Pharm Res 2010:361-74.

Gupta R, Parthi R, Formulation and In Vitro Evaluation of Gastroretentive Floating Drug Delivery System of Ritonavirâ€. Turk J Pharm Sci 2013;10 (1):69-86.

Fumiyoshi Y, Mitsuru H. Pharmacokinetics consideration for targeted drug delivery. J Adv Drug Delivery Rev 2013;65:139-47.

Swetha S, Ravi TA, Gowda DV. Formulation and Evaluation of pectin-HPMC mesalamine tablets coated with Eudragit L100 for ulcerative colitisâ€. J Scholar Res Library Acta Bio-Medica: Atenei Parmensis 2012:1093-102.

Published

31-08-2014

How to Cite

H. N., J., P. K. R., K. V. R., S. H. N., and U. U. M. “FORMULATION AND EVALUATAION OF COLON TARGETED MATRIX TABLET OF NAPROXEN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 183-6, https://journals.innovareacademics.in/index.php/ijpps/article/view/1353.

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