SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 1-(6-NITRO-2H-BENZO[b][1,4]THIAZINE-3(4H)-YLIDENE)HYDRAZINE-1,1-DIOXIDE DERIVATIVES
DOI:
https://doi.org/10.22159/ijpps.2016v8i10.13673Keywords:
1, 4-Benzothiazines, Sulfones, Hydrazines, Anti-microbial activityAbstract
Objective: The objective of this research was to synthesize and evaluate anti-microbial properties of 1-(6-nitro-2H-benzo[b][1,4]thiazine-3(4H)-ylidene)hydrazine-1,1-dioxide derivatives.
Methods: These new compounds were synthesized by reaction of 2H-benzo[b][1,4]thiazin-3(4H)-one with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method.
Results: The FTIR, 1HNMR, 13CNMR and Mass studies confirms the synthesis of some new 1-(6-nitro-2H-benzo[b][1,4]thiazine-3(4H)-ylidene) hydrazine-1,1-dioxide derivatives. Compound 5f showed potent antimicrobial activity whereas compounds 5c and 5e showed moderate antimicrobial activity.
Conclusion: Result obtained in this research work clearly indicated that the compound 5f having methyl at 2 position and nitro groups at 2′ and 4′ position showed the most potent antimicrobial activity.Â
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