FORMULATION AND EVALUATION OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM OF GLICLAZIDE
DOI:
https://doi.org/10.22159/ijpps.2016v8i11.14104Keywords:
Gliclazide, Self-emulsifying drug delivery system (SEDDS), Solubility, Adsorption, Droplet size, Drug releaseAbstract
Objective: Gliclazide (GCZ) is a widely prescribed anti-diabetic drug belongs to class IΙ under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. The present investigations highlight the development of solid self-emulsifying drug delivery system (solid-SEDDS) for improved oral delivery of the poorly water-soluble drug, GCZ.
Methods: Various oils, surfactant and co-surfactant, were screened for their emulsification ability. Ternary phase diagrams were plotted to identify the zone of micro-emulsification. Liquid SEDDS of the drug were formulated using lemon oil as the oil phase, tween 80, as the surfactant, and labrasol, as the co-surfactant. The optimized liquid SEDDS was transformed into free-flowing powder using florite R as the adsorbent.
Results: Self-emulsifying powder retained the self-emulsifying property of the liquid SEDDS. The morphology of solid-SEDDS from scanning electron microscopy studies demonstrated the presence of spherical, granular particles indicating good flowing ability. X-ray powder diffraction studies confirmed solubilization of the drug in the lipid excipients and/or transformation of a crystalline form of the drug to amorphous form. In vitro dissolution studies revealed enhanced release of the drug from solid-SEDDS as compared to plain drug and marketed formulation.
Conclusion: Thus it can be concluded that solid-SEDDS, amenable for the development of solid dosage form, can be successfully developed using florite R with the potential of enhancing the solubility, dissolution rate, and bioavailability of the drug.
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Ashwini G, Choudhary R, Chaitanya CH. Enhancement of solubility and dissolution rate of irbesartan by solid dispersion technique. Asian J Pharm Clin Res 2011;4:36-40.
Pouton CW. Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 2006;29:278–87.
Kumar A, Sharma S, Kamble R. Self-emulsifying drug delivery system (SEDDS): future aspects. Int J Pharm Pharm Sci 2010;2:7-13.
Mu H, Holm R, Mullertz A. Lipid-based formulations for oral administration of poorly water-soluble drugs. Int J Pharm 2013;453:215–24.
Kohli K, Chopra S, Dhar D, Arora S, Khar RK. Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability. Drug Discovery Today 2010;15:958-65.
Hauss DJ. Oral lipid-based formulations. Adv Drug Delivery Rev 2007;59:667-76.
Chakraborty S, Shukla D, Mishra B, Singh S. Lipid-an emerging platform for oral delivery of drugs with poor bioavailability. Eur J Pharm Biopharm 2009;73:1-15.
Tang B, Cheng G, Chun J, Gu, Cai-Hong Xu. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discovery Today 2008;13:606-12.
Kang MJ, Jung SY, Song WH, Park JS, Choi SV, Oh KT, et al. Immediate release of ibuprofen from fuji calin based fast-dissolving self-emulsifying tablets. Drug Dev Ind Pharm 2011;37:1298-305.
Sarkar A, Tiwari A. Pharmacological and pharmaceutical profile of gliclazide: a review. J Appl Pharm Sci 2011;01:11-9.
Nipun TS, Ashraful Islam SM. SEDDS of gliclazide: preparation and characterization by in vitro, ex-vivo and in vivo techniques. Saudi Pharm J 2014;22:343–8.
Raval C, Joshi N, Patel J, Upadhyay U. Enhanced oral bioavailability of olmesartan by using novel solid self-emulsifying drug delivery system. Int J Adv Pharm 2012;2:82-92.
Date AA, Nagarsenkar MS. Design and evaluation of self nano emulsifying drug deliverySystems (SNEDDS) for cefpodoxime proxetil. Int J Pharm 2007;329:166-72.
Beg S, Swain S, Singh HP, Patra CN, Rao ME. Development, optimization and characterization of solid-self nano emulsifying drug delivery systems of valsartan using porous carriers. AAPS PharmSciTech 2012;13:1416-27.
Talegaonkar S, Mustafa G, Akhter S, Iqbal ZI. Design and development of oral oil-in-water nanoemulsion formulation bearing atorvastatin: in vitro assessment. J Dispersion Sci Technol 2010;31:690-701.
Zhang P, Liu Y, Feng N, Xu. Preparation and evaluation of self-micro emulsifying drug delivery system of oridonin. Int J Pharm 2008;355:269-76.
Carr RL. Evaluating flows properties of solids. Chem Eng 1965;18:163-8.
Bakhle SS, Avari JG. Development and evaluation of liquid and solid self-micro emulsifying drug delivery system of lovastatin. Asian J Pharm 2016;10:22-35.
Gupta S, Chavhan S, Sawant KK. Self-nano emulsifying drug delivery system for adefovirdipivoxil: design, characterization, in vitro and ex vivo evaluation. Colloids Surf A 2011;392:145-55.
Bakhle SS, Avari JG. Development and characterization of solid self-emulsifying drug delivery system of cilnidipine. Chem Pharm Bull 2015;63:408-17.
Bakhle SS, Avari JG. Development and evaluation of solid self-micro emulsifying drug delivery system for improved oral delivery of medoxomil. Int J Pharm Sci Res Olmesartan Medoxomil 2015;6:3285-98.
Constantinides PP, Scalart JP, Lancaster C, Marcello J, Marks G, Ellens H, et al. Formulation and intestinal absorption enhancement of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm Res 1994;11:1385-90.
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