SYNTHESIS AND CHARACTERIZATION OF A NOVEL MUCOADHESIVE DERIVATIVE OF PSYLLIUM SEED POLYSACCHARIDE

Authors

  • Monica R.p. Rao Department of Pharmaceutics, AISSMS College of Pharmacy, near RTO, Kennedy Road, Pune 411001, Maharashtra, India
  • Snehal R. Gaikwad Department of Pharmaceutics, AISSMS College of Pharmacy, near RTO, Kennedy Road, Pune 411001, Maharashtra, India
  • Prachi M. Shevate Department of Pharmaceutics, AISSMS College of Pharmacy, near RTO, Kennedy Road, Pune 411001, Maharashtra, India

DOI:

https://doi.org/10.22159/ijpps.2017v9i6.14221

Keywords:

Psyllium seed polysaccharide, Crosslinking, Microwave assisted, Thiolated psyllium seed polysaccharide

Abstract

Objective: In the present study, thiol-functionalization of psyllium seed polysaccharide (PSY) was cross-linked with thioglycolic acid by esterification in an attempt to reveal the mucoadhesive properties of thiolated psyllium seed polysaccharide (TPSY).

Methods: The crosslinking was carried out by the microwave-assisted method. A simplex centroid design was employed to systematically study the mucoadhesive strength, mucoadhesive retention time and drug release profile. Comparative evaluation of carbopol-based ciprofloxacin hydrochloride (HCl) tablets containing PSY and TPSY was carried out. Acute oral toxicity studies and repeated oral toxicity for TPSY were also conducted.

Results: Thiol-functionalization was confirmed by-SH stretch in Fourier Transform infra-red spectra at 2353 cm-1. Thiolation was observed in thiolated PSY (TPSY) by a change in the surface morphology of psyllium from fibrous to granular and resulted in 82 %swelling in deionized water. TPSY was found to contain 102.35 mmol of thiol groups/g as determined by the Ellman's method. The percent increase in mucoadhesive strength of TPSY was found to be 50.31 % as compared to PSY and 128.30 % as compared to carbopol. The percent increase in mucoadhesive retention time of TPSY was found to be 110 % as compared to PSY and 50 % as compared to carbopol.

Conclusion: Mucoadhesion strength and mucoadhesive retention time were greater of tablets containing a higher amount of TPSY. Further, the acute oral toxicity studies and repeated oral toxicity for TPSY proved it as non-toxic and hence safe for human use.

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Published

01-06-2017

How to Cite

Rao, M. R., S. R. Gaikwad, and P. M. Shevate. “SYNTHESIS AND CHARACTERIZATION OF A NOVEL MUCOADHESIVE DERIVATIVE OF PSYLLIUM SEED POLYSACCHARIDE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 6, June 2017, pp. 166-75, doi:10.22159/ijpps.2017v9i6.14221.

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