CLINICALLY STUDY OF TRANSPARENT SOLID SOAP CONTAINING INDONESIAN PROPOLIS WAX IN THREATED LEUKORRHEA CAUSED BY CANDIDA ALBICANS

Authors

  • Muhamad Sahlan Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Somantri Brojonegoro, Kampus UI, Beji, Depok 16424, Indonesia and Natura Propola Institute, Bizhub Serpong, Block GF-10, Gunung Sindur, Bogor, Indonesia
  • Etin Rohmatin Midwifery Departement of Health Polytechnic Republic of Indonesia’s Health Ministry Tasikmalaya

DOI:

https://doi.org/10.22159/ijpps.2017v9i5.14907

Keywords:

Leukorrhea, Propolis wax, Candidiasis, Bar transparent soap

Abstract

Objective: Candida albicans (CA) is one of leading cause leukorrhea due to microbial infection. Propolis wax is a fraction of propolis, and thus its remains as the side product of refined propolis are sufficient to inhibit CA, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus mutans growth. In this study, we used transparent solid soap containing Indonesian propolis wax to treated patients with leukorrhea disease.

Methods: Quasi-Experimental designs that use for the Pre-Experimental design one group pretest-posttest design with a control group who performed on patients with leukorrhea in January 2014 in Tasikmalaya (West Java, Indonesia) district health center by using statistical analysis of T Test Dependent. The study conducted on 36 patients with leukorrhea and positively infected by CA. The transparent soap containing propolis wax 1% and 2% are used for to group I (20 respondents) and group II (10 respondents), and six respondents used as the negative control group.

Results: The results showed that both groups could treat by the soap. The soap significantly effective in decreasing the number of CA, while six respondents in the control group showed a significant in increasing the number of CA. The results revealed that the content of propolis wax 1% and 2% in the preparation of transparent soap significantly influence on the subtraction of the number of patients with CA leukorrhea.

Conclusion: The results obtained in this research work clearly indicated that the transparent soap containing propolis wax 1% and 2% have a potency to against leucorrhea disease caused by CA.

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References

Falahati M, Akhlagi L, Abianeh M, Assadi M, Nami S, Fateh R. Prevalence of Candida albicans and Trichomonas vaginalis infections in women. Life Sci J 2013;479-84.

Gul S, Qamar H, Jawaid W, Bukhari U, Javed Y. Women facing heavy vaginal discharge (leukorrhea) by virtue of unhealthy lifestyle. Int Res J Pharm 2013;4:258-61.

Ghotbi S, Behesti M, Amirizade S. Cause of leukorrhea in fasa, Southern Iran. Shiraz E-Med J 2007;8:58-63.

Alo MN, Anyim C, Onyebuchi AK, Okonkwo EC. Prevalence of asymptomatic co-infection of candidiasis and vaginal trichomoniasis among pregnant women in Abakaliki, South-Eastern Nigeria. J Nat Sci Res 2012;1:87-91.

Panda S, Nagamanasa P, Panda SS, Ramani TV. Incidence of candidiasis and trichomoniasis in leucorrhoea patients. Int J Res Rev 2013;5:92-6.

Mousavi MS, Keshavarz T, Motaseri H, Pakshir K, Yazdani M, Zare N, et al. A comparative study on the therapeutic effect of the propolis vaginal cream and clotrimazole on Candida vulvovaginitis in reproductive-aged women. J Med School Isfahan 2011;117:1.

Duran G, Duran N, Culha G, Ozcan B, Oztas H, Ozer B. In vitro antileishmanial activity of Adana propolis samples on Leishmania tropica: a preliminary study. Parasit Res 2010;102:1217-25.

Farooqui T, Farooqui A. Molecular mechanism underlying the therapeutic activities of propolis: a critical review. Curr Nutr Food Sci 2010;6:186-99.

Ozbilge H, Kaya EG, Albayrak S, Silici S. Antileishmanial activities of ethanolic extract of Kayseri propolis. Afr J Microbiol Res 2010;4:556-60.

Paulino N, Abreu SR, Uto Y, Koyama D, Nagasawa H, Hori H, et al. Anti-inflammatory effects of a bioavailable compound, artepillin C, in Brazilian propolis. Eur J Pharmacol 2008;587:296-301.

Pontin K, Da Silva Filho AA, Santos FF, Silva ML, Cunha WR, Nanayakkara NP, et al. In vitro and in vivo antileishmanial activities of a Brazilian green propolis extract. Parasitol Res 2008;103:487-92.

Ramos AFN, Miranda JL. Propolis: a review of its anti-inflammatory and healing actions. J Venomous Anim Toxins Incl Trop Dis 2007;13:697-710.

Sforcin JM, Bankova V. Propolis: Is there a potential for the development of new drugs. J Ethnopharmacol 2011;133:253-60.

Moorthy K, Aparna A, Punitha T, Vinodhini R, Suresh M, Thajuddin M. In vitro screening of antimicrobial activity of Wrightia tinctoria (Roxb.) R. Br. Asian J Pharm Clin Res 2012;5:54-8.

Panda SK, Bastia AK, Dutta SK. Anticandidal activity of Croton Roxburghii Balak. Int J Curr Pharm Res 2010;2:55-9.

Published

01-05-2017

How to Cite

Sahlan, M., and E. Rohmatin. “CLINICALLY STUDY OF TRANSPARENT SOLID SOAP CONTAINING INDONESIAN PROPOLIS WAX IN THREATED LEUKORRHEA CAUSED BY CANDIDA ALBICANS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 5, May 2017, pp. 275-7, doi:10.22159/ijpps.2017v9i5.14907.

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