EFFECT OF ROTATORY VESTIBULAR STIMULATION ON LEARNING AND MEMORY IN RATS-STANDARDIZATION OF A NOVEL METHOD
Keywords:Rotatory vestibular stimulation, Learning, memory, Hippocampal pyramidal neurones
Objective: To find out the effect of rotatory vestibular stimulation in cognition in rats through examining the behavioural patterns, the alterations in dendritic arborization and changes in AChE activity.
Methods: Rotatory vestibular stimulation was provided in a rotatory vestibular apparatus at a rate of 50 rpm for 5 min, for 30 d for rats. 0.3 mg/kg of physostigmine also administered to rats of another group as a standard drug. No rotatory vestibular stimulation or physostigmine is provided to the control rats. Behavioural analysis, Neuromorphological and biochemical studies were done after vestibular stimulation.
Results: No. of trails for acquisition and retention reduced significantly in treated rats when compared with the control rats. In all the treated rats the dendritic arborization increased significantly, and activity of AChE decreased significantly when compare with the control.
Conclusion: Rotatory vestibular stimulation enhances learning and memory via increasing dendritic arborization and inhibiting acetyl-cholinesterase activity in rats.Â
Caroline Gurvich, Jerome J Maller, Brian Lithgow, Saman Haghgooie, Jayashri Kulkarni. Vestibular insights into cognition and psychiatry. Brain Res 2013;1537:244-59.
Sailesh Kumar Sai, Archana R, Mukkadan JK. Thinking with your sixth sense. Res J Pharm Biol Chem Sci 2014;5:481-5.
Sajad Haghshenas, Motahare S Hosseini, Azin S, Aminjan. A possible correlation between vestibular stimulation and auditory comprehension in children with attention deficit or hyperactivity disorder. Psychol Neurosci 2014;7. http://dx.doi.org/10.3922/j.psns.2014.009.
Sailesh Kumar Sai, Jissa George, Mukkadan JK. Cancer pain relief by vestibular stimulationâ€“a hypothesis. Health Sci 2013b;4:JS004D.
Lang E, Walsh RM. Vestibular function testing. Iraq J Med Sci 2010;179:173-8.
Sailesh Kumar Sai, Mukkadan JK, Shetty AK. Can controlled vestibular stimulation reduces stressâ€“a review. Health Sci 2013a;2:js001.
Mora R, Dellepiane M, Barettini L, Crippa B, Salami A. Electronystagmography in a migraine equivalent syndrome. Otolaryngol Head Neck Surg 2009;140:566â€“72.
Devi L, Diwakar L, Raju TR, Bindu M Kutty. Selective neuro-degeneration of hippocampus and endorhinal cortex correlates with spatial learning impairments in rats with bilateral ibotenate lesions of ventral subiculum. Brain Res 2003;960:9-15.
Praveen KV. The innovation of an alternated dual task for assessing spatial learning and memory in rats: an investigation by altering the hippocampal integrity using pharmacological and lesion approach, PhD Thesis, MG Uty, Kottayam; 2001.
Nived Arjun. An experimental study on the effect of Mandookaparni swarasa on behavioural and neuro-morphological aspects of learning and memory in rats: MAMS-Thesis; 2013.
Silviya RJ. Enhancement of memory in rats with Centella Asiatica. Biomed Res 2010;21:429-32.
Haroutunian V, Baenes E, Davis KL. Cholinergic modulation of memory in rats. Psychopharmacology 1985a;87:266-71.
Haroutunian V, Baenes E, Davis KL. Pharmacological alleviation of cholinergic lesion induced memory deficits in rats. Life Sci 1985b;37:945-52.
Billye Ann Cheatum, Allison A Hammond. Physical activities for improving childrenâ€™s learning and behaviour. A guide to Sensory motor development; 2000. p. 143-8.
Rubin RT, Mandell AJ, Crandall PH. Corticosteroid responses to limbic stimulation in man: localization of stimulus sites. Science 1966;153:767â€“8.
Holst E Von, Grisebach E. Einflusz des bogengangen systems auf die subjektive lotrechte beim menschen. Naturwissenschaften 1951;38:67â€“8.
Tribukait A. Semicircular canal and saccular influence on the subjective visual horizontal during gondola centrifugation. J Vestib Res 1999;9:347â€“57.
Sailesh Kumar Sai, Archana R, Mukkadan JK. Controlled vestibular stimulation: a physiological method of stress relief. J Clin Diagn Res 2014b;8:1-2.
Sailesh KS, Mukkadan JK. Psychoimmuno modulation by controlled vestibular stimulation. J Clin Exp Res 2013a;1:68-70.
Sailesh Kumar Sai, Mukkadan JK, Controlled Vestibular. Stimulation: a novel treatment for insomnia. Int J Health Sci Res 2013;3:127-34.
Robert W Stackman, Ann S Clark, Jeffrey S Taube, Hippocampal Spatial. Representations require vestibular input. Hippocampus 2002;12:291-303.
Vitte E, Derosier C, Cartin Y, Besthoz A, Hasbour D, Soulie D. Activation of the hippocampal formation by vestibular stimulation: a functional magnetic resonance imaging study. Exp Brain Res 1996;112:523-6.
Horii A, Takeda N, Mochizuki T, Okakura Mochizuki K, Yamamoto Y, Yamatodani A. Effects of vestibular stimulation on acetylcholine release from rat hippocampus, an in vivo microdialysis study. J Neurophysiol 1994;72:605-11.
Oâ€™Mara SM, Rolls ET, Berthoz A, Kenser RP. Neurons responding to whole body motion in the primate hippocampus. J Neurosci 1994;14:6511-23.
Sharp P E, Blair HT, Tzanetos DB. Influence of vestibular and visual motion information on the spatial firing patterns of hippocampal place cells. J Neurosci 1995;15:173-89.
Gavrilov VV, Wiener SI, Berthoz A. Enhanced hippocampal theta EEG during whole body rotations inawake restrained rats. Neurosci Lett 1995;197:239-41.
Knierim JJ, Kudrimoti HS, McNaughton BL, Place cells, head direction cells, and the learning of landmark stability. J Neurosci 1995;15:1648-59.
Mathews BL, Campbell KA, Deadwyler SA. Rotational stimulation disrupts spatial learning in fornix lesioned rats. Behav Neurosci 1988;102:35-42.
Vingerhoets RA, Van Gisbergen JA, Medendorp WP. Verticality perception during off-vertical axis rotation. J Neurophysiol 2007;97:3256-68.
Nived Arjun. An experimental study on the effect of mandookaparni swarasa on behavioural and neuromorphological aspects of learning and memory in rats: MAMS-Thesis; 2013.
Soule J. Brain-derived neurotrophic factor and control of synaptic consolidation in the adult rat brain. Biochem Soc Trans 2006;34:600-4.
Devi NP, Mukkadan JK. The impact of rotatory vestibular stimulation and Centella asiatica on spatial learning and memory in wistar albino rats. Res J Pharm Biol Chem Sci 2015;6:911-9.
Devi NP, Mukkadan JK. The impact of rotatory vestibular stimulation and Myristica fragrans on spatial learning and memory in wistar albino rats. J Innovations Pharm Biol Sci 2016;3:17-32.
Devi NP, Mukkadan JK. The impact of rotatory vestibular stimulation and Curcuma longa on spatial learning and memory in wistar albino rats. Asian J Pharm Clin Res 2016;9:167-73.
Squire LR. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 1992;99:195-231.
Satoh M, Ishihara K, Katruki H. Different susceptibilities of long term potentiation in CA3 and CA1 regions of guinea pig hippocampal slice to nootropic drugs. Neurosci Lett 1988;93:236-41.