• Simerpreet Kaur Department of Botanical and Environmental Sciences, Guru Nanak Dev Universtiy, Amritsar 143005, Punjab (India)
  • Jatinder K. Katnoria Department of Botanical and Environmental Sciences, Guru Nanak Dev Universtiy, Amritsar 143005, Punjab (India)



Particulate matter, Carcinogenicity, Tumor-inducing ratio


Objective: Aim of the study was to screen the suspended particulate matter for their role in enhancing angiogenesis employing crown gall tumor assay.

Methods: Particulate matter (PM10) samples were collected, on glass fiber filter paper at the rate of 1.12–1.14 m3/min for 8 hr using high volume sampler, from six different sites of Amritsar city. Aqueous extracts of suspended particulate matter were prepared using a mechanical shaker for 24 hour and the filtrate was centrifuged and lyophilized.

Results: Maximum (34.67±1.764) tumors were induced by samples collected from Crystal chowk whereas tumor inducing ratio (TIR) was found to be comparably high for two sites viz., Crystal chowk and Bhandari bridge.

Conclusion: High tumor inducing ratio at the above-mentioned sites was correlated to high traffic emission from automobile exhaust. Crown gall tumor assay has been proved to be rapid, economical and reliable screening assay for angiogenesis agent.


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How to Cite

Kaur, S., and J. K. Katnoria. “ROLE OF SUSPENDED PARTICULATE MATTER IN ANGIOGENESIS EMPLOYING CROWN GALL TUMOR ASSAY”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 1, Jan. 2017, pp. 34-37, doi:10.22159/ijpps.2017v9i1.15440.



Original Article(s)