PICEATANNOL AMELIORATES CISPLATIN-INDUCED HISTOLOGICAL AND BIOCHEMICAL ALTERATIONS IN RATS KIDNEY
DOI:
https://doi.org/10.22159/ijpps.2017v9i10.15518Keywords:
Cisplatin, Piceatannol, Nephrotoxicity, Antioxidants, NF-kBAbstract
Objective: The present study was designed to investigate the effect of different doses of piceatannol (PIC) on cisplatin-induced biochemical and histological alterations in rat kidney.
Methods: Male Wistar rats received a single intraperitoneal (i. p.) injection of cisplatin (7 mg/kg). PIC was given in different daily doses (5, 10 and 20 mg/kg) i. p., for seven days, starting two days before cisplatin injection. Nephrotoxicity was evaluated by means of measurement of blood urea nitrogen (BUN), serum creatinine and histopathological examination of the kidney. We also investigated the antioxidant effect of the most effective dose of PIC by measuring reduced glutathione (GSH) and lipid peroxides levels. Moreover, the ability of PIC to affect nuclear factor kappa B (NF-kB) expression was determined by immunohistochemical analysis.
Results: A single dose of cisplatin (7 mg/kg) significantly increased BUN and creatinine levels, as well as relative kidney weight, compared to the control group. In addition, significant histopathological alterations including tubular necrosis, hemorrhage and casts formation were observed. PIC was given in different doses (5, 10 and 20 mg/kg) for 7 d, starting 2 d before cisplatin injection. PIC dose 10 mg/kg was the most effective in preventing these alterations. PIC significantly increased GSH level and decreased lipids peroxidation compared to cisplatin group. Moreover, PIC significantly mitigated cisplatin-induced expression of NF-kB.
Conclusion: PIC has the potential to ameliorate cisplatin-induced renal injury.Â
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