QUALITY OF LIFE OF CHRONIC KIDNEY DISEASE PATIENTS WITH ROUTINE HEMODIALYSIS IN GENERAL HOSPITALS IN SLEMAN YOGYAKARTA

Authors

  • Sihombing J. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia
  • Hakim L. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia
  • Andayani T. M. Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia
  • Irijanto F. Hemodialysis Department Gadjah Mada University Academic Hospital, Yogyakarta, Indonesia

DOI:

https://doi.org/10.22159/ijpps.2017v9i2.15844

Keywords:

CKD, Hemodialysis, QOL, Erythropoietin

Abstract

Objective: To elicit quality of life (QOL) of chronic kidney disease (CKD) patients with routine hemodialysis receiving erythropoietin, to compare the QOL of CKD patients with routine hemodialysis receiving different erythropoietin, and to explore the change in QOL over six months for patients managed in the hospitals.

Methods: A multicenter prospective study was conducted among adult CKD patients in Yogyakarta. QOL was measured using kidney disease quality of life–short form (KDQOL–SFTM) questionnaire and a FACIT fatigue scale questionnaire. CKD patients were divided into 2 groups: those receiving erythropoietin alpha (n=74) and those receiving erythropoietin beta (n=39). Both groups were asked to complete the KDQOL–SFTM questionnaire and a FACIT fatigue scale questionnaire two times in six months range.

Results: In the first period, the average rate of the KDQOL-SF and FACIT for CKD patients receive erythropoietin alpha compared to CKD patients receive erythropoietin beta was 77.24: 80.21 and 3.35: 3.49 while in the second period, the average rate of the KDQOL-SF and FACIT for CKD patients receive erythropoietin alpha compared to CKD patients receive erythropoietin beta was 80.45: 83.95 and 3.45: 3.56.

Conclusion: Erythropoietin can improve QOL of CKD patients with routine hemodialysis, while erythropoietin beta gives more improvement, but statistically, it doesn't different significantly.

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References

Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013;382:260–72.

Somvanshi S, Khan NZ, Ahmad M. Anemia in chronic kidney disease patients. Clin Queries: Nephrol 2012;I:198–204.

Lu WX, Jones-Burton C, Zhan M, Salzberg DJ, Moore J Jr, Fink JC. Survival benefit of recombinant human erythropoietin administration prior the onset of end-stage renal disease: variations across surrogates for quality of care and time. Nephron Clin Pract 2005;101:79–86.

Levin NW, Lazarus JM, Nissenson AR. National cooperative rHu erythropoietin study in patients with chronic renal failure–an interim report. The national cooperative rHu erythropoietin study group. Am J Kidney Dis 1993;22:3-12.

Naci H, Lissovoy G, Hollenbeak C, Custer B, Hofmann A, McClellan W, et al. Historical clinical and economic consequence of anemia management in patients with end-stage renal disease on dialysis using erythropoietin stimulating agents versus routine blood transfusions: a retrospective cost-effectiveness analysis. J Med Econ 2012;15:293–304.

Jelkmann W. Molecular biology of erythropoietin. Intern Med 2004;43:649–59.

Walters SJ. The quality of life outcomes in clinical trials and health-care evaluation: a practical guide to analysis and interpretation. John Wiley and Sons Ltd pub; 2009.

Cella D, Yount S, Sorensen M, Chartash E, Sengupta N, Grober J. Validation of the functional assessment of chronic illness therapy-fatigue scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol 2005;32:811-9.

Webster K, Cella D, Yost K. The functional assessment of chronic illness therapy (FACIT) measurement system; properties, applications, and interpretation. Health Qual Life Outcomes 2003;1:1–7.

Tennant KF. Assessment of fatigue in older adults: the FACIT-fatigue scale (Version 4). General assessment series from The Hartford Institute for Geriatric Nursing, New York, College of Nursing; 2012;20:1-2.

Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006;355:2085-98.

Hansen RA, Chin H, Blalock S, Joy MS. Predialysis chronic kidney disease: evaluation of the quality of life in clinic patients receiving comprehensive anemia care. Res Social Administrative Pharm 2009;5:143-53.

Fukuhara S, Lopes AA, Bragg-Gresham JL, Kurokawa K, Mapes DL, Akizawa T, et al. the Health-related quality of life among dialysis patients on three continents: the dialysis outcomes and practice patterns study. Kidney Int 2003;64:1903-10.

Kostro JZ, Hellmann A, Kobiela J, Skora I, Lichodziejewska-Niemierko M, Debska-Slizien A, et al. Quality of life after kidney transplantation: a prospective study. Transplant Proc 2016;48:50-4.

Cheung YB, Seow YY, Qu LM, Yee ACP. Measurement properties of the Chinese version of kidney disease quality of life short form (KDQOL-SFTM) in end-stage renal disease patients with poor prognosis in singapore. J Pain Symptom Manage 2012;44:923-32.

Unruh M, Miskulin D, Yan G, Hays RD, Benz R, Kusek JW, et al. Racial differences in health-related quality of life among hemodialysis patients. Kidney Int 2004;65:1482-91.

Perlman RL, Finkelstein FO, Liu L, Roys E, Kiser M, Eisele G, et al. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the renal research institute CKD study. Am J Kidney Dis 2005;45:658-66.

Lee BO, Lin CC, Chaboyer W, Chiang C-L, Hung CC. The fatigue experiences of hemodialysis patients in Taiwan. J Clin Nurs 2007;16:407-13.

Kazemi M, Nasrabadi AN, Hasanpour M, Hassankhani H, Mills J. Experience of Iranian persons receiving hemodialysis: a descriptive, exploratory study. Nurs Health Sci 2011;13:88-93.

Murali R, Sathyanarayana D, Muthusethupathy MA. Assessment of quality of life in chronic kidney disease patients using the kidney disease quality of life short formTM questionnaire in the Indian population: a community-based study. Asian J Pharm Clin Res 2015;8:271-4.

Sklar AH, Riesenberg LA, Silber AK, Ahmed W, Ali A. Post dialysis fatigue. Am J Kidney Dis 1996;28:732-6.

Rocco DG, Mercieri A, Yavuzer G. Multidimensional health status assessment of chronic hemodialysis patients: the impact of quality of life. Eur Medicophys 2006;42:113-9.

Sklar AH, Newman N, Scott R, Semenyuk L, Schultz J, Fiacco V. Identification of factor responsible for post dialysis fatigue. Am J Kidney Dis 1999;34:464-70.

Wang SY, Zang XY, Liu JD, Gao M, Cheng M, Zhao Y. Psychometric properties of the functional assessment of chronic illness therapy-fatigue (FACIT-Fatigue) in Chinese patients receiving maintenance dialysis. J Pain Symptom Management 2015;49:135-42.

Published

01-02-2017

How to Cite

J., S., H. L., A. T. M., and I. F. “QUALITY OF LIFE OF CHRONIC KIDNEY DISEASE PATIENTS WITH ROUTINE HEMODIALYSIS IN GENERAL HOSPITALS IN SLEMAN YOGYAKARTA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 2, Feb. 2017, pp. 213-6, doi:10.22159/ijpps.2017v9i2.15844.

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