WOUND HEALING POTENTIAL OF YOUNG LEAVES OF TRITICUM AESTIVUM ON ALLOXAN INDUCED DIABETIC RATS
Keywords:
Diabetic induced wound healing, Excision wound model, Alloxan, Triticum aestivum, WheatgrassAbstract
Objective: Wheatgrass is known to have several medicinal properties to treat various disorders. Triticum aestivum Linn. is a traditional medicinal plant apparently used for bowel disorders, skin inflammation, infection, mouth sores and wound healing. It is also used for conditions as varied as headache to a folk remedy for diabetes. No data was found for the simultaneous use of it for wound healing and diabetes. The present study was designed to study the wound healing activity with the complications of diabetes. The objective is to help those people suffering from diabetes and not getting relief from pain and wounds.
Methods: The 5% methanolic extract ointment of Triticum aestivum young leaves were evaluated for its wound healing activity in alloxan induced diabetic rats using excision wound model. The percent wound closure and their epitelialisation periods were observed for 16 days.
Result: The wound treated with Triticum aestivum grass extract was healed in very efficient manner and the healing was very close to the standard intadine.
Conclusion: The Triticum aestivum young leaves extract has shown similar wound healing property as compared with intadine. The quercetine and other grass factors present in the extract may be responsible for promoting the wound healing activity.
Downloads
References
Marwaha RK, Bansal D, Kaur S, Trehan A. Wheat grass juice reduces transfusion requirement in patients with Thalassemia major:a pilot study. J Indian Pediatr 2004;41:716-20.
Fernandes CJ, Donovan DJ. Natural antioxidant therapy for patients with hemolytic anaemia. J Indian Pediatr 2005;42:618-20.
Reynolds CA. DNA technology base cellular assay used to measure specific biological activity in wheat grass extract. J Australasian Integrative Medicine Association 2005; www. aima.net.av.
Mukhopadhyay S, Sonali D, Gupta PR, et al. Effect of wheat grass juice in supportive care of terminally ill solid organ cancer patients:Experience from eastern India. J Cancer Prevention Res 2008;1(Suppl7):B139.
Gruskin B. Chlorophyll-its therapeutic place in acute and suppurative disease. Am J Surg 1940;49:49-55.
Collings G. Chlorophyll and adrenal cortical extract in the local treatment of burns. Am J Surg 1945;70:58-63.
Egner PA, Munoz A, Kensler TW. Chemoprevention with chlorophyll in individuals exposed to dietary aflatoxin. J Mutat Res 2003;523-24:209-16.
Ben-arye E, Goldin E, Wengrower D, Stamper A, Kohn R, Berry E. Wheat grass juice in the treatment of active distal ulcerative colitis:A randomized double blind placebo controlled trial. J Scand Gastroenterol 2002;37:444-9.
CN Lai. Chlorophyll:The active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro. J Nutrition and Cancer 1979;1(3):19-21.
Gruskin B. Chlorophyll-its therapeutic place in acute and suppurative disease. Preliminary report of clinical use and rationale. Am J Surg 1940;49-55.
Smith L, Livingston A. Chlorophyll. An experimental study of its water soluble derivatives in wound healing. Am J Surg 1943;62:358-69.
Bowers W. Chlorophyll in wound healing and suppurative disease. Am J Surg 1947;73:37-50.
Brett D. Chlorophyllin-a healer? A hypothesis for its activity. J Wounds 2005;17(7):190-5.
Chernomorsky S, Segelman A. Review article:Biological activities of chlorophyll derivatives. J New Jersey Med 1988;85(8suppl):669-73.
Lam C, Brush, B. Chlorophyll and wound healing. Experimental and clinical study. Am J Surg 1950;8:204-10.
Shaikh M, Quazi M, Nandedkar R. Hypoglycemic effect of wheatgrass juice in alloxan induced diabetic rats. J Pharma Tutor 2011;10.
Rajagopalan R, Pajaniradje S, Gaud C, Shakya G. Protective role of wheatgrass on oxidative stress in streptozotocin induced type 2 diabetic rats. Int J Pharm Pharm Sci 2012;4 (3Suppl):415-23.
Singh J, Sethi J, Yadav M, Sood S, Gupta V. Effect of Triticum aestivum juice on wound healing in rats. Int J of Nat Pro Sci 2011;1:15-20.
Rangari V D. Pharmacognosy and Phytochemistry. J Career Publications 2007;95-6.
Morton JJ, Molane MH. Evaluation of vulnerary activity by an open wound procedure in rats. Archives Internationales de Pharmacodynemiie et de Therapie 1972;196(1suppl):117-26.
Chah KF, Eze CA, Emuelosi CE, Esimoe CO. Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants. J Etnnopharmacol 2006;104:164-7.