A ROLE FOR PHALERIA MACROCARPA (SCHEFF) BOERL. EXTRACTS IN THE MANAGEMENT OF WOMEN'S PATHOLOGICAL CONDITIONS: A RESEARCH REVIEW
DOI:
https://doi.org/10.22159/ijpps.2017v9i3.16001Keywords:
Phaleria macrocarpa, Premenstrual syndrome, Endometriosis, Breast cancer, Cervical cancer, Hormone imbalanceAbstract
Phaleria macrocarpa (Scheff) Boerl is a medicinal plant that originates from West Papua, Indonesia. The fruit of this plant is known to contain numerous different compounds that produce different bioactivities. Many of these bioactivities are related to women pathological conditions. The purpose of this review is to evaluate the effect of P. macrocarpa fruit extract in the management of these conditions. Different studies have proven that P. macrocarpa extract helps regulate hormone imbalance in women with problems relating to their menstruation cycle, especially during premenstrual syndrome. It helps alleviate symptoms of primary dysmenorrhea and endometriosis through its bioactivity as anti-inflammation, apoptosis inducer, anti-angiogenic and anti-oxidant agent. P. macrocarpa fruit extract also showed selective anti-proliferative, anti-inflammatory, and anti-angiogenic activity on breast and cervical cancer cells. It regulates cancer cell progression through numerous different pathways, making it highly favourable to be developed as a cancer treatment, whether as a single treatment or as an adjunct therapy. In conclusion, P. macrocarpa extract has great potential to be developed into treatments for women's pathological conditions. However, further study, both preclinical and clinical studies are needed to ascertain its use in women to be effective and safe.
Downloads
References
Shukla R, Chakravarty M, Gautam MP. Indigenous medicine used for the treatment of gynaecological disorders by tribal of Chhattisgarh, India. J Med Plants Res 2008;2:356-60.
Krishnaveni M, Mirunalini S. AMLA–the role of ayurvedic therapeutic herb in cancer. Asian J Pharm Clin Res 2011;4:13-7.
Altaf R, Asmawi MZB, Dewa A, Sadikun A, Umar MI. Phytochemistry and medicinal properties of Phaleriamacrocarpa (Scheff.) Boerl. extracts. Pharmacogn Rev 2013;7:73–80.
Ali RB, Atangwho IT, Kaur N, Abraika OS, Ahmad M, Mahmud R, et al. Bioassay-guided antidiabetic study of Phaleriamacrocarpa fruit extract. Molecules 2012;17:4986-5002.
Lay MM, Karsani SA, Mohajer S, Malek SNA. Phytochemical constituents, nutritional values, phenolics, flavonols, flavonoids, antioxidant and cytotoxicity studies on phaleriamacrocarpa (Scheff.) boerl fruits. BMC Complementary Altern Med 2014;14:152.
Hendra R, Ahmad S, Sukari A, Shukor MY, Oskoueian E. Flavonoid analyses and antimicrobial activity of various parts of Phaleriamacrocarpa (Scheff.) Boerl fruit. Int J Mol Sci 2011;12:3422-31.
Daud D, Badruzzaman NA, Sidik NJ, Tawang A. Phaleria macrocarpa fruits methanolic extract reduces blood pressure and blood glucose in spontaneous hypertensive rats. J Appl Pharm Sci 2016;6:158-61.
Sabina E, Zaidul ISM, Ghafoor K, Jaffri JM, Sahena F, Babiker EE, et al. Screening of various parts of phaleriamacrocarpa plant for α-glucosidase inhibitory activity. J Food Biochem 2016;40:201-10.
Triastuti A, Park HJ, Choi JW. Phaleriamacrocarpa suppresses nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats. Nat Prod Sci 2009;15:167-72.
Yonkers KA, O’Brien PMS, Eriksson E. Premenstrual syndrome. Lancet 2008;371:1200–10.
Braverman PK. Premenstrual syndrome and premenstrual dysphoric disorder. J Pediatric Adolescent Gynecol 2007;20:3-12.
Oyola MG, Portillo W, Reyna A, Foradori CD, Kudwa A, Hinds L, et al. Anxiolytic effects and neuroanatomical targets of estrogen receptor-β (ERβ) activation by a selective ERβ agnost in female mice. Endocrinology 2012;153:837–46.
Dalal PK, Agarwal M. Postmenopausal syndrome. Indian J Psychiatry 2015;57:S222–32.
Arpels JC. The female brain hypestrogenic continuum from the premenstrual syndrome to menopause. A hypothesis and reviews of supporting data. J Reprod Med 1996;41:633-9.
Hurst BS, Gardner SC, Tucker KE, Awoniyi CA, Schlaff WD. Delayed oral estradiol combined with leuprolide increases endometriosis-related pain. J Soc Laparoendoscopic Surgeons 2000;4:97-101.
Morton JH, Additon H, Addison RG, Hunt L, Sullivan JJ. A clinical study of premenstrual tension. Am J Obstet Gynecol 1953;65:1182-91.
Marino M, Galluzzo P, Ascenzi P. Estrogen signaling multiple pathways to impact gene transcription. Curr Genomics 2006;7:497–508.
Brinton FD, Thompson RF, Foy MC, Baudry M, Wang J, Finch CE, et al. Progesterone receptors: form and function in the brain. Front Neuroendocrinol 2008;29:313–39.
Olsen RW, Delorey TM. GABA receptor physiology and pharmacology. In: Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD. editors. Basic Neurochemistry. 6th ed. Philadelphia (PA): Lippincott-Raven; 1999.
Backstrom T, Andreen L, Bjorn I, Johansson IM, Logren M. The role of progesterone and GABA in PMS/PMDD. In: O’Brien PMS, Rapkin AJ, Schmidt PJ. The Premenstrual Syndromes: PMS and PMDD. Florida: Taylor and Francis Group; 2007. p. 117-20.
Huo L, Straub RE, Schmidt PJ, Shi K, Vakkalanka R, Weinberger DR, et al. Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene. Biol Psychiatry 2007;62:925–33.
Budoff PW. The use of prostaglandin inhibitors for the premenstrual syndrome. J Reprod Med 1983;28:469-78.
Horrobin DF. The role of essential fatty acids and prostaglandins in the premenstrual syndrome. J Reprod Med 1983;28:465-8.
Mayo JL. Premenstrual syndrome: a natural approach to management. Appl Nutr Sci Reports 1999;5:1-8.
Irwin J, Morse G, Aiddick D. Dysmenorrhea induced by autologous transfusion. Obstet Gynecol 1981;58:286-90.
Budoff PW. Zomepirac sodium in the treatment of primary dysmenorrhea syndrome. N Engl J Med 1982;307:714-24.
Wood C, Jakubowicz D. The treatment of premenstrual symptoms with mefenamic acid. Br J Obstet Gynaecol 1980; 87:627-30.
Tjandrawinata RR, Nofiarny D, Susanto LW, Hendri P, Clarissa A. Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleriamacrocarpa. Int J General Med 2011;4:465–76.
Bulun SE. Endometriosis. N Engl J Med 2009;360:268–79.
Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril 2008;90:247–57.
Saeed SA, Suria A. Prostaglandings, menstruation, and menstrual disorders. J Pak Med Assoc 1986. p. 120-6.
Proctor M, Farquhar C. Diagnosis and management of dysmenorrhea. Br Med J 2006;332:1134–8.
Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 2011;31:986–1000.
Kim JJ, Kurita T, B SE. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev 2013;34:130–62.
Tandrasasmita OM, Lee JS, Baek SH, Tjandrawinata RR. Induction of cellular apoptosis in human breast cancer by DLBS1425, a Phaleriamacrocarpacompound extract, via downregulation of P13-kinase/AKT pathway. Cancer Biol Ther 2010;10:814–23.
Tjandrawinata RR, Arifin PF, Tandrasasmita OM, Rahmi D, Aripin A. DLBS1425, a Phaleria macrocarpa (Scheff.) Boerl. extract confers antiproliferative and proapoptosis effects via eicosanoid pathway. J Exp Ther Oncol 2010;8:187-201.
Sugiwati SK, Leonardus BS, Bintang M. α-Glucosidase inhibitory activity and hypoglycemic effect of Phaleriamacrocarpa fruit pericarp extracts by oral administration to rats. J Appl Sci 2006;6:2312–6.
Tandrasasmita OM, Sutanto AM, Arifin PF, Tjandrawinata RR. Anti-inflammatory, antiangiogenic, and apoptosis-inducing activity of DLBS1442, a bioactive fraction of phaleriamacrocarpa, in a RL95-2 cell line as a molecular model of endometriosis. Int J Women’s Health 2015;7:161–9.
Wiweko B, Puspita CG, Tjandrawinata R, Situmorang H, Harzif AK, Pratama G, et al. The effectiveness of phaleriamacrocarpa bioactive fraction in alleviating endometriosis and/or adenomyosis related pain. eJurnal Kedokteran Indonesia 2015;3:51-6.
Cancer Among Women. Centers for Disease Control and Prevention. Url: Available from: http://www.cdc.gov/ cancer/dcpc/data/women.htm. [Last accessed on 01 Oct 2016]
Claria J. Cycooxygenase-2 biology. Curr Pharm Design 2003;9:2177-90.
Richardsen E, Uglehus RD, Due J, Busch C, Busund LT. COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67. Cancer Epidemiol 2010;34:316-22.
Bae SH, Jung ES, Park YM, Kim BS, Kim BK, Kim DG, et al. Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. Clin Cancer Res 2001;7:1410-8.
Hill R, Li Y, Tran LM, Dry S, Calvopina JH, Garcia A, et al. Cell-intrinsic role of COX-2 in pancreatic cancer development. Mol Cancer Ther 2012;11:2127-37.
Cheng J, Xiao-Ming F. Role of cyclooxygenase-2 in gastric cancer development and progression. World J Gastroenterol 2013;19:7361–8.
Subbaramaiah K, Norton L, Gerald W, Dannenberg AJ. Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer evidence for the involvement of AP-1 and PEA3. J Biol Chem 2002;277:18649-657.
Tjandrawinata RR, Arifin PF, Tandrasasmita OM, Rahmi D, Aripin A. DLBS1425, a phaleriamacrocarpa (Scheff.) Boerl. extract confers antiproliferative and proapoptosis effects via eicosanoid pathway. J Exp Ther Oncol 2010;8:187-201.
Tandrasasmita OM, Lee JS, Baek SH, Tjandrawinata RR. Induction of cellular apoptosis in human breast cancer by DLBS1425, a phaleriamacrocarpa compound extract, via downregulation of PI3-kinase/AKT pathway. Cancer Biol Ther 2010;10:1-11.
Anggadiredja K, Tjandrawinata RR. Cardiovascular effects of Phaleriamacrocarpa extracts combined with mainstay FAC regimen for breast cancer. Cardiovasc Toxicol 2015;15:90-9.
Arends MJ, Buckley CH, Wells M. Aetiology, pathogenesis, and pathology of cervical neoplasia. J Clin Pathol 1998;51:96-103.
Zhao B, Hu M. Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells. Oncol Lett 2013;6:1749–55.
Faried A, Bolly HMB, Septiani L, Kurnia D, Arifin MZ, Wirakusumah FF. Potential of Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, for targeting multiple malignancy signalling pathways: an introductory overview. Eur J Med Plants 2015;11:1-17.
Shi L, Lei Y, Srivastava R, Qin W, Chen JJ. Gallic acid induces apoptosis in human cervical epithelial cells containing human papillomavirus type 16 episomes. J Med Virol 2016;88:127–34.
Published
How to Cite
Issue
Section
