DEVELOPMENT OF COLON-SPECIFIC MULTI PARTICULATE DRUG DELIVERY SYSTEM OF FENOVERINE
Keywords:
Fenoverine, Multiparticulate system, Colon specific system, Eudragit S 100Abstract
Objective: The main objective of this study was to formulate and evaluate colon-specific multi- particulate drug delivery system of fenoverine, using Eudragit S 100 as enteric coating polymer.
Methods: Microparticles were prepared by oil/water emulsion solvent evaporation technique and characterized for micromeritic properties, encapsulation efficiency, percentage yield and particle size. Various analytical techniques such as FTIR, DSC, PXRD, and SEM were used to characterize microparticles. In vitro release studies were performed in 900 ml of enzyme free SGF (pH 1.2) for 2 h followed by enzyme free SIF (pH 7.4) containing 2% Tween 80 till the end of test using USP paddle apparatus. Drug release data was subjected to release kinetic studies and effect of stirring rate on particle size and percent entrapment of microparticles was also studied.
Results: In vitro release studies showed that microparticles were able to release the drug in a controlled manner with zero order rate kinetics; ‘n' values obtained from the Korsmeyer Peppas model showed that the release mechanism was non-fickian type. SEM studies revealed that microparticles were smooth and spherical in shape. The DSC and PXRD studies of drug loaded microparticles showed amorphous state of the drug in the microparticles. Mean particle size was reduced with increase in stirring rate but percent drug entrapment of was found to be high 72.12 ± 1.63.
Conclusion: Colon specific microparticles prevent premature drug release in simulated upper GIT and maximize the drug release in simulated intestinal environment at controlled rate over a period of 24h.
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