METHYLPHENIDATE: PROCONVULSANT EFFECT AND ACTION ON ACETYL CHOLINESTERASE ACTIVITY IN YOUNG AND ADULT MICE

Authors

  • Maria Isabel Linhares Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Fortaleza, 60.431970, CE, Brazil
  • Edith T. Venancio Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Fortaleza, 60.431970, CE, Brazil
  • Camila Nayane C. Lima Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Fortaleza, 60.431970, CE, Brazil
  • Mariana L. Feitosa Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Fortaleza, 60.431970, CE, Brazil
  • Luiza Herbene M. S. Salbiano Department of Pharmacy, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Rua Capitão Francisco Pedro, 1210, Fortaleza, 60.430372, CE, Brazil
  • Alana G. Souza Department of Pharmacy, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Rua Capitão Francisco Pedro, 1210, Fortaleza, 60.430372, CE, Brazil
  • Klistenes Alves Department of Pharmacy, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Rua Capitão Francisco Pedro, 1210, Fortaleza, 60.430372, CE, Brazil
  • Francisca Clea F. Sousa Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceara, RuaCel. Nunes de Melo,1127, Fortaleza,60.431970, CE, Brazil
  • David J. Woods School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand.
  • Lissiana M. V. Aguiar Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceara, RuaCel. Nunes de Melo,1127, Fortaleza,60.431970, CE, Brazil
  • Marta Maria D. E. F. Fonteles Department of Physiology and Pharmacology, Laboratory of Neuropharmacology, School of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Fortaleza, 60.431970, CE, Brazil, Department of Pharmacy, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Rua Capitão Francisco Pedro, 1210, Fortaleza, 60.430372, CE, Brazil

Keywords:

Acetylcholinesterase, Hippocampus, Methylphenidate, Seizures, Striatum

Abstract

Objective: Methylphenidate (MPH) is a derivative of piperidine, structurally related to amphetamine. It is the most widely psychostimulant used in Brazil for treating attention deficit disorder and hyperactivity. This drug was investigated in an epilepsy model induced by pilocarpine and on acetylcholinesterase (AChE) activity in young and adult mice.

Methods: The control group was treated with saline. The treated groups received MPH (2.5, 5, 10 or 20 mg/kg) in single dose, followed by pilocarpine (400mg/Kg). The groups were observed for1h after treatment.

Results: MPH, in all doses, was efficacious in decreasing both the latency to first seizures and the survival percentage in young and adult animals. Determination of AChE activity in the hippocampus and striatum of young and adult animals, after pilocarpine-induced status epilepticus, demonstrated that pretreatment with MPH reduced AChE activity only in the striatum.

Conclusion: Our findings suggest that MPH has proconvulsant action and cholinergic neurotransmission system can play a role in this effect.

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Published

01-07-2014

How to Cite

Linhares, M. I., E. T. Venancio, C. N. C. Lima, M. L. Feitosa, L. H. M. S. Salbiano, A. G. Souza, K. Alves, F. C. F. Sousa, D. J. Woods, L. M. V. Aguiar, and M. M. D. E. F. Fonteles. “METHYLPHENIDATE: PROCONVULSANT EFFECT AND ACTION ON ACETYL CHOLINESTERASE ACTIVITY IN YOUNG AND ADULT MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 7, July 2014, pp. 547-51, https://journals.innovareacademics.in/index.php/ijpps/article/view/1758.

Issue

Vol 6, Issue 7, 2014

Section

Original Article(s)