GASTRIC ANTISECRETORY AND ANTIULCER PROPERTIES OF ETHANOLIC EXTRACTS OF LEAVES OF ANDROGRAPHYS PANICULATA
Keywords:
A paniculata, Gastric secretion, Gastric ulcers, Cytoprotection, Gastric wall mucusAbstract
Objective: To study the gastric anti-secretory and cytoprotective action of ethanolic extract of leaves of Andrographys paniculata.
Methods: Effect of ethanolic extract of leaves of A. paniculata gastro-antisecretory and cytoprotective activity was studied in vivo by using gastric wall mucus determination, hypothermic restraint stress-induced ulcers, idomethacin-induced gastric ulcers, reserpine-induced gastric ulcers and necrotizing agent-induced gastric ulcers (cytoprotection studies) methods.
Results: Ethanolic extract of leaves of A. paniculata produced a significant decrease in gastric secretion in pylorous ligated rats and a highly significant cytoprotective effect against 80% ethanol-0.6 M HCl, 0.2 M NaOH, and 25% NaCl-induced cytodestruction.
Conclusion: Pretreatment with the extract significantly prevented hypothermic stress-induced gastric wall mucus depletion. These findings suggest that a significant antisecretory and cytoprotective action A. paniculata can be responsible for its antiulcer activity.
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