FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF A MODEL ANTI-HYPERTENSIVE DRUG
DOI:
https://doi.org/10.22159/ijpps.2017v9i11.18967Keywords:
Propranolol, Orodispersible tablets, Direct compression technique, SuperdisintegrantsAbstract
Objective: The rationale of the current work was to formulate and evaluate orodispersible tablets by direct compression technique with a vision to augment patient compliance and rapid onset of action.
Methods: Nine orodispersible formulations of propranolol were formulated by direct compression method using sodium starch glycolate, crospovidone and croscarmellose sodium as the super disintegrants. The prepared formulations were evaluated for wetting time, drug content, in vitro disintegration time, dispersion time, dissolution time and also projected to kinetic treatment to know the pattern of drug release. Further, the discovered promising formulation was subjected to stability studies.
Results: Based on the results obtained, formulation F9 containing6 mg of croscarmellose sodium exhibited good wetting time, dispersion time, and disintegration time and drug release compared to orodispersible tablets prepared with other super disintegrants. The stability studies piloted as per International Conference on Harmonisation guidelines on the promising formulationF9disclosedno significant changes in the colour (white), drug content (94.87±0.141 mg), hardness (2.93±0.18 kg/cm2), disintegration time (17.11±0.089 s), and drug release after 4 w. After 60 s, the percentage drug release of F9 was found to be 98.52 % and 96.30 % after 1 and 4 w, respectively.
Conclusion: Orodispersible tablets of propranolol hydrochloride were formulated successfully by employing direct compression technique. From the investigation, it can be reasonably concluded that F9 batch orodispersible tablets of propranolol with 6 mg of crospovidone exhibited maximum cumulative drug release in 60 s.
Downloads
References
Dey P, Maiti S. Orodispersible tablets: a new trend in drug delivery. J Nat Sci Biol Med 2010;1:2-5.
Nagar P, Singh K, Chauhan I, Verma M. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharm Sci 2011;1:35-45.
Swamy N, Sachin, Abbas Z. Design and characterization of oral dispersible tablets of enalapril maleate using a co-processed excipient. J Appl Pharm Sci 2012;2:40-9.
Hirani JJ, Rathod DA, Vadalia KR. Orally disintegrating tablets: a review. Trop J Pharm Res 2009;8:161.
Abhay A, Swati A, Gayti A. Oral dispersible tablets: novel technology and development. Int J Pharm Sci Rev Res 2013;20:193-9.
Velmurugan S, Sundar V. Oral disintegrating tablets: an overview. Int J Pharm Chem Sci 2010;1:1-12.
Ibrahim HK, El-Setouhy DA. Valsartan orodispersible tablets: formulation, in vitro/in vivo characterization. AAPS PharmSciTech 2010;11:189-96.
Revathi S, Moulali SK, Dhanaraju MD. Formulation and evaluation of orodispersible valsartan tablets. Pharm Lett 2015;7:315-24.
Rewar S, Singh C, Bansal B, Pareek R, Sharma A. Oral dispersible tablets: An overview; development, technologies and evaluation. Int J Res Dev Pharm Life Sci 2014;3:1223-35.
Deshpande K, Ganesh N. Orodispersible tablets: an overview of formulation and technology. Int J Pharma Biol Sci 2011;2:726-34.
Sivaramaiah N, Alekhya M, Anusha M, Bhargav C, Harish G. Formulation and evaluation of oral dispersible tablets of propranolol hcl. Am J Biol Pharm Res 2014;1:160-9.
Mohsin A, Nimbalakr NE, Sanaullah S, Aejaz A. Formulation and evalution of mouth dissolving tablets of amitriptyline hydrochloride by direct compression technique. Int J Pharm Pharm Sci 2010;2:204-10.
Goyani SM, Shah P, Vyas B, Shah D. Formulation and evaluation of orally disintegrating tablets of meclizine hydrochloride. Int Res J Pharm 2012;3:196-9.
Leela MK, Ramana G, Digpati R. Formulation and evaluation of oral disintegrated tablets of alfuzosin hydrochloride using super disintegrants. J Appl Pharm Sci 2011;1:161-5.
Vijaya K, Mishra D. Rapidly disintegrating oral tablets of meloxicam. Indian Drugs 2006;43:117â€21.
Hirave R, Kondawar M. Development and evaluation of herbal fast dissolving tablet of capparis divaricata lam. Int J Adv Pharma 2017;6:24-30.
Sai PB, Syamala S, Vinod kN, Voleti VK, Madhusudhan C. Formulation and evaluation of orodispersible tablets of clonazepam using natural super disintegrants. IOSR-J Pharm Biol Sci 2014;9:47-52.
Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 2010;67:217-23.
Gupta M, Vishal P. Formulation and evaluation oral dispersible tablets of cinnarizine. J Drug Delivery Ther 2013;3:12-7.
Karthik N, Vijaya KB, Sateesh KV. Different techniques to enhance the dissolution rate of lovastatin: formulation and evaluation. Asian J Pharm Clin Res 2013;6:56-60.
Reddy MNK, Hussain MA, Rao TR, Kishna TR, Pavan V. Formulation and evaluation of naproxen oral disintegraing tablets. Int J Pharm Biol Sci 2012;2:303-16.
Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123-33.
Sumit D, Sayantan M, Laxmi G. Preparation, characterization and evaluation of floating microparticles of ciprofloxacin. Int J Appl Pharm 2017;9:1-8.
Shashank C, Vipin KA, Anurag V, Navneet V, Sunil S. Comparative evaluation of natural and semisynthetic super disintegrants in the formulation of orodispersible tablets of norfloxacin. Int J Pharm Pharma Sci 2012;4:576-83.
Ananda K, Kiran KT, Gyana JR. Development, formulation and evaluation of solifinacin succinate immediate release oral tablets by using starch and hpmc. Int J Res Pharm Nano Sci 2013;2:91-100.
Mangesh MS, Nagesh ST. Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate. Braz J Pharm Sci 2013;49:784-92.
Chandrasekhar P, Shahid MS, Niranjan BM. Formulation and evaluation of oral dispersible tablets of antihypertensive drug atenolol. Int J Pharm 2013;3:79-84.
Parag P, Tejal P, Rajesh P. Formulation and evaluation of mouth dissolving tablet for the antihypertensive drug. Pharmagene 2013;1:10-20.
Published
How to Cite
Issue
Section
