FORMULATION AND EVALUATION OF TIME-RELEASE COMPRESSION COATED TABLET CONTAINING ACEBROPHYLLINE FOR CHRONOTHERAPY OF ASTHMA
Keywords:
Compression coated tablet, Lag time, Chronotherapy, Acebrophylline, AsthmaAbstract
Objective: The aim of present research was to develop compression coated tablet for pulsatile drug delivery of Acebrophylline used for chronotherapy of asthma. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of asthma.
Methods: The compression coated tablets containing Acebrophylline in the inner core were formulated by direct compression method with an outer coating of different amounts of HPMC K4M.
Results: The release profile of press coated tablet exhibited a lag time depending upon the amount of HPMC K4M in compression coating, followed by burst release. Optimization was done using 32 factorial design considering two independent factors at three levels. Data was evaluated statistically by Stat Ease Design Expert 7.0.0 software. The optimized batch F6 gave a lag time of 6 hr and drug release of 94% in which the concentration of HPMC K4M is 40% and the concentration of SSG is 2.5 %.
Conclusion: The chronodelivery of Acebrophylline was achieved by formulating the tablet by compression coating technique.
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References
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