ANTIDIABETIC EFFECT OF EXTRACTS OF BLUMEA LACERA DC. IN STREPTOZOTOCIN INDUCED HYPERGLYCEMIC RATS

Authors

  • Diptirani Rath Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Bhubaneswar-751003, Odisha, India
  • Snigdha Rani Panigrahy Department of Pharmacology, MKCG Medical College and Hospital, Brahmapur - 760004, Odisha, India
  • Sandeep Kumar Panigrahi Department of Community Medicine, IMS and SUM Hospital, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Bhubaneswar-751003, Odisha, India
  • Durga Madhab Kar Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Bhubaneswar-751003, Odisha, India
  • Laxmidhar Maharana Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Kalinga Nagar, Bhubaneswar-751003, Odisha, India

DOI:

https://doi.org/10.22159/ijpps.2017v9i10.19851

Keywords:

Blumea lacera, Metformin, Blood glucose level, Bio-chemical level, Insulin, Glycated hemoglobin

Abstract

Objective: Present study of this research was undertaken to evaluate the antidiabetic activities of extracts of aerial parts of Blumea lacera DC. (Asteraceae) in streptozotocin (STZ) induced hyperglycemic rat.

Methods: The methanol extracts (MEBL) and aqueous extract (AEBL) of B. lacera DC. were investigated in streptozotocin (STZ) induced hyperglycemic rats at a dose level of 200 and 400 mg/kg body weight, in oral glucose tolerance test (OGTT), acute and subacute antidiabetic (30 d) models keeping a parallel group of metformin (250 mg/kg body weight) as standard drug. The serum biochemical parameters, histopathology of liver and pancreaswere examined and analyzed statistically.

Results: Treatment with methanol extract of B. lacera (MEBL) at a dose of 200 mg/kg and 400 mg/kg body weight, significantly decrease (p<0.05) blood glucose level from 289.83±9.83 and 289.83±2.71 to 201.83±8.87 and 105.00±2.05 respectively with corresponding percentage fall of blood glucose to 30.40±1.79 and 63.78±0.59. It also improved the glycated haemoglobin (HbA1c) near to normal value, restored the lipid and bio-chemical level and rejuvenate beta cells of pancreas, thereby improve insulin secretion.

Conclusion: The result of the present study concluded that extracts of B. lacera DC possess marked antidiabetic activity. However, methanol extract of B. lacera (MEBL) at the dose of 400 mg/kg showed significant dose dependent antidiabetic effects without any destruction and restores the structure of liver and pancreas of hyperglycemic rats.

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References

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Published

02-10-2017

How to Cite

Rath, D., S. R. Panigrahy, S. K. Panigrahi, D. M. Kar, and L. Maharana. “ANTIDIABETIC EFFECT OF EXTRACTS OF BLUMEA LACERA DC. IN STREPTOZOTOCIN INDUCED HYPERGLYCEMIC RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 10, Oct. 2017, pp. 218-23, doi:10.22159/ijpps.2017v9i10.19851.

Issue

Vol. 9, Issue 10, 2017

Section

Original Article(s)
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