SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF FUSED ISOXAZOLE DERIVATIVES USING GRINDING METHOD
Keywords:
Isoxazolone derivative, Pyrazoloisoxazole derivatives, Hydrazino and hydrazides compounds, Grinding and antimicrobial activityAbstract
Objective: A facile and efficient synthesis of new pyrazoloisoxazole, isoxazolopyridine and isoxazolopyrimidine derivatives is discribed through interaction of isoxazolone derivative with different nitrogen nucleophiles. Nine of the newly synthesized compounds were tested for antibacterial activities.
Methods: Interaction of isoxazolone derivative with different nitrogen nucleophiles under grinding conditions.
Results: New pyrazoloisoxazole, isoxazolopyridine and isoxazolopyrimidine derivatives were synthesized and the structures of the prepared compounds were elucidated from spectral data.
Conclusion: 4-(4-Chlorobenzylidene)-3-phenylisoxazol-5(4H)-one was utilized as key intermediate for the synthesis of some new heterocycles, namely pyrazoloisoxazole, isoxazolopyridine and isoxazolopyrimidine derivatives under grinding conditions. Most of the newly synthesized products revealed moderate activity against Gram-negative and Gram-positive bacteria.
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