• Manyasree D. Department of Biochemistry, Acharya Nagarjuna University, Nagarjuna Nagar 522510, India
  • Kiranmayi P. Department of Biochemistry, Acharya Nagarjuna University, Nagarjuna Nagar 522510, India
  • Ravi Kumar R. V. S. S. N. Department of Physics, Acharya Nagarjuna University, Nagarjuna Nagar 522510, India



Al2O3 nanoparticles, XRD, FTIR, SEM, EDX, Antibacterial activity and MIC


Objective: In the present study, synthesized alumina (Al2O3) nanoparticles were characterized and their antibacterial activity against gram positive and gram negative organisms were studied.

Methods: The synthesis was carried out by coprecipitation method using aluminium sulfate and NaOH as precursors. The synthesized aluminium oxide nanoparticles were characterized by using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR) and scanning electron microscope (SEM) with Energy Dispersive X-ray Analysis (EDX) techniques. Besides, this study determines the antibacterial activity and minimum inhibitory concentration (MIC) of Al2O3 nanoparticles against gram-positive (Staphylococcus aureus and Streptococcus mutans) and gram-negative (E. coli and Proteus vulgaris) bacteria.

Results: The average crystallite size of Al2O3 nanoparticles was found to be 35 nm by X-ray diffraction. FT-IR spectrum exhibited the peaks at 615 and 636 were assigned to the aluminium oxide stretching. The EDX measurements indicated the presence of Al along with O peaks. It indicates the purity of the sample. The antimicrobial assay revealed that E. coli showed a maximum zone of inhibition (39 mm) at 50 mg/ml concentration of Al2O3 nanoparticles.

Conclusion: In conclusion, aluminium oxide is a good antibacterial agent against both gram positive and gram-negative organisms.


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How to Cite

D., M., K. P., and R. K. R. V. S. S. N. “SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF ALUMINIUM OXIDE NANOPARTICLES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 10, no. 1, Jan. 2018, pp. 32-35, doi:10.22159/ijpps.2018v10i1.20636.



Original Article(s)