EVALUATION OF CALLINECTES CHITOSAN AS A SUPERDISINTEGRANT IN METRONIDAZOLE TABLET

Emmanuel O. Olorunsola; Musiliu O. Adedokun; Ekaete I. Akpabio

doi:10.22159/ijpps.2017v9i10.20788

Authors

Emmanuel O. Olorunsola Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria
Musiliu O. Adedokun Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria
Ekaete I. Akpabio Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria

DOI:

https://doi.org/10.22159/ijpps.2017v9i10.20788

Keywords:

Callinectes gladiator, Chitosan, Metronidazole, Superdisintegrant

Abstract

Objective: The objective of this study is to evaluate callinectes chitosan as a superdisintegrant in tablet formulation; superdisintegrants are incorporated into tablets at concentrations below 5% of tablet weight to effect prompt break-up of tablets after administration.

Methods: Chitosan was extracted from shells of Callinectes gladiator. The polymer was characterized and then used as a disintegrant (in comparison with Ac-Di-Sol^Â® and corn starch) at concentrations of 2, 4 and 8% for the formulation of metronidazole tablets. The micromeritic properties of granules; and mechanical and release properties of the tablets were studied.

Results: A yield of 36.7% chitosan having degree of deacetylation of 62.7% was obtained from the crab shell. Fourier Transform Infrared absorption bands at 1495 and 3240 cm^-1 typical of N-H bending and stretching respectively; and endothermic peak of 159 Â°C typical of melting of chitosan were obtained. No adverse interaction between the chitosan and metronidazole was observed. The disintegration times of tablets containing 2, 4 and 8% chitosan were 12.2, 10.4 and 9.3 min respectively.

Conclusion: Callinectes chitosan is suitable for use as a superdisintegrant in tablets. It appears to be superior to corn starch as disintegrant although less effective compared to Ac-Di-Sol^Â®. However, the relative cheapness and ready availability of chitosan would make it to be preferred to Ac-Di-Sol^Â®.

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