ASSOCIATION OF PATIENT RELATED RISKFACTORS WITH EFFECTIVENESS OF PALLIATIVE CHEMOTHERAPY IN CANCER PATIENTS
DOI:
https://doi.org/10.22159/ijpps.2017v9i10.21037Keywords:
Risk factors, Chemotherapy, Adverse drug reactions, Response evaluation criteria in solid tumoursAbstract
Objective: To assess the association of some risk factors on the effectiveness of palliative chemotherapy treatment in cancer patients.
Methods: A prospective observational study was conducted in the department of radiotherapy for a period of 6 mo. Ages, Gender, Cancer type, Physical Functioning, Anxiety and Depression, Medical Social Support, Comorbidities, Adverse Drug Reactions are defined as risk factors. The effectiveness of palliative chemotherapy treatment was defined according to Response Evaluation Criteria in Solid Tumors (RECIST). Mean and standard deviation was calculated from the age. The association between risk factors and the effectiveness of chemotherapy treatment was found by chi-square test. The level of significance was taken as p<0.05.
Results: The association between risk factors and effectiveness of palliative chemotherapy treatment was found using Chi-Square test. The mean age of patients in the present study was 50.57±12.62 y. Females were more commonly affected. The Majority of the patients were illiterate, married and homemaker. Reproductive system related cancers (50.66%) were more predominant in the present study. A statistically significant association was observed between age (p=0.027), physical functioning (p=0.0076), anxiety (p=0.000072) and depression (p=0.000016), co-morbidities (p<0.00001) and adverse drug reactions (p<0.00001) with effectiveness of chemotherapy treatment.
Conclusion: By predicting these risk factors prior to the initiation of treatment, we can minimize their unfavourable effect on the effectiveness of treatment.
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References
Nature.com: Cancer. Available from: http://http:// www.nature.com/subjects/cancer/. [Last accessed on 20 May 2017]
Roeland EJ, LeBlanc TW. Palliative chemotherapy: oxymoron or misunderstanding? BMC Palliative Care 2016;15:33.
Lyman GH, Kuderer NM. Epidemiology of febrile neutropenia. Support Cancer Ther 2003;1:23-35.
Lyman GH, Morrison VA, Dale DC, Crawford J, Delgado DJ, Fridman M. OPPS working group; ANC Study Group. Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy. Leuk Lymphoma 2003;44:2069-76.
Tan M. Social support and coping in Turkish patients with cancer. Cancer Nurs 2007;30:498–504.
Due P, Holstein B, Lund R, Modvig J, Avlund K. Social relations: network, support and relational strain. Soc Sci Med 1999;48:661-73.
Jones RA, Taylor AG, Bourguignon C, Steeves R, Fraser G, Lippert M, et al. Family interactions among African American prostate cancer survivors. Family Community Health 2008;31:213–20.
Ardith D, Barbara G, Charles G, Natalya V. Physical functioning: effect of behavioral intervention for symptoms among individuals with cancer. Nurs Res 2006;55:161–71.
Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Macdonald JS, Benson AB. 3rd. Fuchs CS. Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol 2003;21:433-40.
Gross CP, McAvay GJ, Guo Z, Tinetti ME. The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer. Cancer 2007;109:2410-9.
Sarfati D, Tan L, Blakely T, Pearce N. Comorbidity among patients with colon cancer in New Zealand. N Z Med J 2011;124:76-88.
Lee L, Cheung WY, Atkinson E, Krzyzanowska MK. Impact of comorbidity on chemotherapy use and outcomes in solid tumors: a systematic review. J Clin Oncol 2011;29:106-17.
Riechelmann RP, Del Giglio A. Drug interactions in oncology: how common are they? Ann Oncol 2009;20:1907-12.
Blower P, de Wit R, Goodin S, Aapro M. Drug-drug interactions in oncology: why are they important and can they be minimized? Crit Rev Oncol Hematol 2005;55:117-42.
Cancer. gov: Psychological Stress and Cancer. Available from: https://www.cancer.gov/about-cancer/coping/feelings/stress-fact-sheet. [Last accessed on 20 May 2017]
Prakash MN, Vaishali RM, Anagha VK, Prabhuswami H, Mahesh C. Effectiveness of planned teaching programme on knowledge regarding cervical cancer among women. Asian J Pharm Clin Res 2017;10:335-8.
Aiswarya Purushothaman, Roshni PR. A retrospective study on etiological factors, patient characterstics and prescription pattern of oral carcinoma in a tertiary care hospital. Asian J Pharm Clin Res 2015;8:160-2.
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