CNS DEPRESSANT, SEDATIVE AND ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FRUIT OF PIPER CHABA REVEALED AFTER NEUROPHARMACOLOGICAL SCREENING
Keywords:
Piper chaba, Piperaceae, Anxiolytic, Sedative, Depressant, GABA (Gamma amino butyric acid), DMSO (Dimethyl Sulfoxide)Abstract
Objective: Different ailments can be treated by multiple approaches. Since ancient civilization plant material have been used successfully for treating diseases. Plants contain active ingredients which are beneficial for treatment of multiple diseases. The purpose of the study was to evaluate the neuropharmacological effects of ethanolic extract of fruit of Piper chaba.
Methods: Piper chaba's ethanolic extract was diluted in DMSO and administered orally at 300mg/kg according to weight of mice for 21 days. A number of tests were then performed to evaluate CNS activity.
Results: The results showed reduced number of cage crossing, head dips, decreased central and peripheral square crossing, reduced struggling time in forced swim test and decreased time spends in light and dark test.
Conclusion: From our results it is concluded that after acute dosing ethanolic extract of fruit of Piper chaba possesses CNS depressant, mild anxiolytic and sedative effect.
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