• Sana Sarfaraz Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Karachi 74600, Pakistan
  • Rahila Najam Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi 74600, Pakistan
  • Abeer Sarfaraz House Officer Jinnah Post Graduate Medical Center


Piper chaba, Piperaceae, Anxiolytic, Sedative, Depressant, GABA (Gamma amino butyric acid), DMSO (Dimethyl Sulfoxide)


Objective: Different ailments can be treated by multiple approaches. Since ancient civilization plant material have been used successfully for treating diseases. Plants contain active ingredients which are beneficial for treatment of multiple diseases. The purpose of the study was to evaluate the neuropharmacological effects of ethanolic extract of fruit of Piper chaba.

Methods: Piper chaba's ethanolic extract was diluted in DMSO and administered orally at 300mg/kg according to weight of mice for 21 days. A number of tests were then performed to evaluate CNS activity.

Results: The results showed reduced number of cage crossing, head dips, decreased central and peripheral square crossing, reduced struggling time in forced swim test and decreased time spends in light and dark test.

Conclusion: From our results it is concluded that after acute dosing ethanolic extract of fruit of Piper chaba possesses CNS depressant, mild anxiolytic and sedative effect.


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How to Cite

Sarfaraz, S., R. Najam, and A. Sarfaraz. “CNS DEPRESSANT, SEDATIVE AND ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FRUIT OF PIPER CHABA REVEALED AFTER NEUROPHARMACOLOGICAL SCREENING”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 11, Nov. 2014, pp. 186-9,



Original Article(s)