IN VITRO ANTIOXIDANT, ANTIMICROBIAL AND ADMET STUDY OF NOVEL FURAN/BENZOFURAN C-2 COUPLED QUINOLINE HYBRIDS

Anantacharya Rajpurohit; Nayak D. Satyanarayan; Sameer Patil; Kittappa M. Mahadevan; Adarsha H. J.

doi:10.22159/ijpps.2017v9i11.21413

Authors

Anantacharya Rajpurohit Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Centre, Kadur 577548, Chikkmagluru Dt., Karnataka St. India
Nayak D. Satyanarayan Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Centre, Kadur 577548, Chikkmagluru Dt., Karnataka St. India
Sameer Patil Department of Post Graduate Studies and Research in Biochemistry, Jnana Sahyadri, Kuvempu University Shankaraghatta 577451, Shivamogga Dt., Karnataka State, India
Kittappa M. Mahadevan Department of Chemistry, Kuvempu University, Post Graduate Centre, Kadur 577548, Chikkmagluru Dt., Karnataka St. India
Adarsha H. J. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012 India

DOI:

https://doi.org/10.22159/ijpps.2017v9i11.21413

Keywords:

DPPH, Lipinski, ADMET, toxicity, Escherichia coli and Aspergillus flavus

Abstract

Objectives: Synthesis of novel 2-(benzofuran-2-yl) and 2-(furan-2-yl) quinoline-4- carboxylates and their [2-(1-benzofuran-2-yl) quinolin-4-yl] methanol, [2-(1-furan-2-yl) quinolin-4-yl] methanol and its derivatives for antioxidant, antimicrobial and ADMET study.

Methods: Synthesis was carried with conventional method and the structures were confirmed by IR, ¹H NMR, ¹³C NMR and mass spectral analysis. The antioxidant activity was performed by DPPH and H₂O₂ radical scavenging method. Antimicrobial investigation was established by cup plate and food poison technique. The in silico absorption, distribution, metabolism, excretion and toxicity (ADMET) study of the drug was carried out in ACD/lab-2.

Results: The antioxidant activity results revealed that, compounds 4b-c, 5a-b, 10c and 10f exhibited good DPPH radical and hydrogen peroxide scavenging activity. The antibacterial results revealed that, compounds 4c, 5a-b, 10b, 10d and 10f exhibited good activity against Escherichia coli, Klebsiella pneumonia and Salmonella typhimurium. Further, the antifungal activity results showed that, compounds 4c, 5c and 10c-e were showing good activity against Aspergillus flavus and Candida neoformans. Â The mean value of P<0.05 were considered to be statistically significant. The ADMET results revealed that compounds emerged as a potential candidate for antioxidant and antimicrobial agents.

Conclusion: The study reveals that compounds containing furan/benzofuran coupled heterocycles are play the important role for activity as they possess potent antioxidant and antimicrobial agents. The in silico ADME analysis also suggesting the compounds were in acceptable range to obey the pharmacokinetic parameters.Â

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