PREVALENCE AND RISK FACTORS OF ESSENTIAL HYPERTENSION AND NEW ONSET OF DIABETES IN ESSENTIAL HYPERTENSION IN RURAL POPULATION OF HARYANA

Vikas Jhawat; Sumeet Gupta; Bimal K. Agarwal; Partha Roy; Vipin Saini

doi:10.22159/ijpps.2018v10i2.23891

Authors

Vikas Jhawat Department of Pharmacology, M.M. College of Pharmacy, M.M. University, Mullana, (Ambala), Haryana, India
Sumeet Gupta Department of Pharmacology, M.M. College of Pharmacy, M.M. University, Mullana, (Ambala), Haryana, India
Bimal K. Agarwal Department of Medicine, M.M. Institute of Medical Sciences and Research, M.M. University, Mullana, (Ambala), Haryana, India
Partha Roy Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand
Vipin Saini Department of Pharmacology, M.M. College of Pharmacy, M.M. University, Mullana, (Ambala), Haryana, India

DOI:

https://doi.org/10.22159/ijpps.2018v10i2.23891

Keywords:

Anthropometric Parameters, Antihypertensive Therapy, Essential Hypertension, New Onset of Diabetes, Prevalence Study, Rural Area

Abstract

Objective: We conducted a well-designed prevalence study in a rural population of Haryana in Mullana rural area to find out the latest prevalence of essential hypertension, the prescription pattern of antihypertensive drugs and the associated risk of new onset of diabetes.

Methods: A retrospective study was carried out on the patient data (2672 patients) from the years 2009 to 2013 at OPD of M. M. University hospital, Mullana to find the previous year's prevalence of different diseases, including essential hypertension, new onset of diabetes and associated risk factors, prescription pattern of antihypertensive drug therapy. Based on the above results, a prospective study was conducted from January 2015 to December 2016 and total 510 patients (270 essential hypertension and 240 essential hypertension with new onset of diabetes) and 270 normal individuals were recruited in the study.

Results: The retrospective study, a total of 2672 patients' data was evaluated which showed 41.21% prevalence of essential hypertension, 11.83% new onset of diabetes in Essential hypertension patients and 15.87% diabetic patients. Antihypertensive monotherapy was prescribed to 59.85% patients and combination therapy to 40.15% patients while that of a prospective study showed 40.37% patients of monotherapy and 59.63% patients of combination therapy. The prospective study also showed that different anthropometric parameters were significantly associated with risk of hypertension and new onset of diabetes except for age and height.

Conclusion: An increase in the prevalence of essential hypertension and associated risk factors was observed when compared with previous studies and retrospective study. It is clearly seen by the change in drug therapy pattern and different anthropometric parameters. Implementation of a large scale awareness program is needed to combat these metabolic diseases.

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References

Mohan V. Seedat YK, Pradeepa R. The rising burden of diabetes and hypertension in southeast asian and african regions: need for effective strategies for prevention and control in primary health care settings. Int J Hypertens 2013;1-14. http://dx.doi.org/10.1155/2013/409083

Swami SS, Swami SC, Patil VW, Kanhere AM. Hypertension and diabetes in India: a review. Int J Clin Biochem Res 2015;2:54-8.

Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Angelantonio ED, et al. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens 2014;32:1170-7.

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217â€“23.

Cheung BMY, Li C. Diabetes and hypertension: Is there a common metabolic pathway? Curr Atheroscler Rep 2012;14:160â€“6.

Kannel WB, Wilson PW, Zhang TJ. The epidemiology of impaired glucose tolerance and hypertension. Am Heart J 1991;121:1268-73.

Sahay BK: API-ICP guidelines on DM. J Assoc Physicians India 2007;55:1â€“50.

Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. J Hypertens 2001;37:53â€“9.

Shah A, Afzal M. Prevalence of diabetes and hypertension and association with various risk factors among different Muslim populations of Manipur, India. J Diabetes Metab Disord 2013;12:52.

Gupta S, Jhawat V. Induction of type 2 diabetes mellitus with antihypertensive therapy: is there any role of alpha-adducin, ACE, and IRS-1 Gene? Value Health Regional Issues 2017;12c:90â€“8.

Bakris GL. Maximizing cardiorenal benefit in the management of hypertension: achieve blood pressure goals. J Clin Hypertens 1999;1:141â€“7.

Gupta S, Agrawal BK, Sehajpal PK, Goel RK. Prevalence and predictors of essential hypertension in the rural population of Haryana, India: a hospital-based study. J Rural Trop Public Health 2011;10:29-34.

Gupta S, Chattopadhyaya I, Agrawal BK, Sehajpal PK, Goel RK. Correlation of renin-angiotensin system (RAS) candidate gene polymorphisms with response to Ramipril in patients with essential hypertension. J Postgrad Med 2015;61:21-6.

World Health Organization. A global brief on hypertension. World Health Day; 2013. p. 1-39.

Thilip KG, Prabhavathi K, Karthick N, Poornima KN, Saravanan A. Evaluation of pre-hypertension, hypertension and its associated factors among 1st year medical students. Asian J Pharm Clin Res 2014;7:32-5.

Suhadi R, Linawati Y, Wulandari ET, Viriginia DM, Setiawan CH. The metabolic disorders and cardiovascular risk among lower socioeconomic subjects in yogyakarta-Indonesia. Asian J Pharm Clin Res 2017;10:367-2.