ORAL ANTICOAGULANT PRESCRIPTION ANALYSIS FOR UTILISATION PATTERN AMONG IN-PATIENTS AT A TERTIARY CARE HOSPITAL

Authors

  • Reshma Elsa Jeny Department of Pharmacy Practice, M. S. Ramaiah College of Pharmacy, Rajiv Gandhi University of Health Sciences, M. S. R. I. T Post Bengaluru 560054 Karnataka, India
  • Jenny Susan Sabu Department of Pharmacy Practice, M. S. Ramaiah College of Pharmacy, Rajiv Gandhi University of Health Sciences, M. S. R. I. T Post Bengaluru 560054 Karnataka, India
  • Mamatha Krishna Murthy Department of Pharmacy Practice, M. S. Ramaiah College of Pharmacy, Rajiv Gandhi University of Health Sciences, M. S. R. I. T Post Bengaluru 560054 Karnataka, India
  • Nagamalesh Udigala Madappa Department of Pharmacy Practice, M. S. Ramaiah College of Pharmacy, Rajiv Gandhi University of Health Sciences, M. S. R. I. T Post Bengaluru 560054 Karnataka, India

DOI:

https://doi.org/10.22159/ijpps.2018v10i3.24102

Keywords:

Prescribing pattern, Oral anticoagulants, International normalised ratio, Drug-drug interactions

Abstract

Objective: Selection of oral anticoagulants (OACs) in patients with thromboembolic diseases is complex and equivocal in nature, owing majorly to the non-adherence to standard clinical guidelines. Moreover, there is a scarcity of data on utilisation pattern of OACs in Indian population. Our primary objective was to analyse the prescribing pattern of OACs among in-patients with thromboembolic disorders. The secondary objective was to determine the significant predictors that affect their utilisation pattern.

Methods: This prospective observational study examined the clinical data over 6 mo from in-patients on oral anticoagulation with warfarin and acenocoumarol. Patients were recruited into 2 study groups: coronary artery disease (CAD) and non-CAD to analyse the prescription pattern. Potential predictors of utilisation pattern were evaluated for significance with logistic regression analysis for CAD group.

Results: Prescription analysis highlights preference of acenocoumarol (72.4%) over warfarin among 232 in-patients in the study. Lack of achievement of target international normalised ratio (INR) levels was noticed in 74.2% of the study population. 57.8% of cases belonged to CAD group (males 76.7%; mean age 59.4±13.5 y). Valvular heart disease (VHD) was the significant predictor (p =0.001) of warfarin utilisation among CAD patients while male gender, heart failure (HF) and arrhythmia were significant for acenocoumarol.

Conclusion: Predominance of age<60 y and male gender was observed in the study. Acenocoumarol was preferred over warfarin in all the in-patient departments. VHD, male gender, HF and arrhythmia significantly affected the OAC utilisation.

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Published

01-03-2018

How to Cite

Jeny, R. E., J. S. Sabu, M. K. Murthy, and N. U. Madappa. “ORAL ANTICOAGULANT PRESCRIPTION ANALYSIS FOR UTILISATION PATTERN AMONG IN-PATIENTS AT A TERTIARY CARE HOSPITAL”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 10, no. 3, Mar. 2018, pp. 76-80, doi:10.22159/ijpps.2018v10i3.24102.

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