PREVALENCE AND RISK FACTORS OF GASTROESOPHAGEAL REFLUX DISEASE (GERD) IN ADULT KASHMIRI POPULATION

Authors

  • Rakesh Kumar Koul Department of Medicine, GMC Srinagar Jammu and Kashmir (India)
  • Shagufta Parveen Department of Pharmacology,GMC Srinagar Jammu and Kashmir (India)
  • Padma Lahdol Department of Medicine, GMC Srinagar Jammu and Kashmir (India)
  • Prof Samia Rasheed Department of Medicine, GMC Srinagar Jammu and Kashmir (India)
  • Nisar A. Shah Department of Medicine and Gastroenterology, GMC Srinagar Jammu and Kashmir (India)

DOI:

https://doi.org/10.22159/ijpps.2018v10i8.25894

Keywords:

Gastroesophageal reflux disease (GERD), Prevalence, Risk factors, Co-morbidity, Severity

Abstract

Objective: The study was conducted with the objective of studying the prevalence of gastroesophageal reflux disease (GERD) and to study various factors associated with it in adult Kashmiri population.

Methods: It was a community based prospective cross-sectional observational study conducted by the Department of Medicine and Gastroenterology, GMC Srinagar over a period of 24 mo upon native Kashmiris from urban as well as rural areas as a study group. A total of 2600 subjects above the age of 18 y were studied and the overall prevalence of disease was calculated and also the associated (risk) factors were looked for.

Results: The overall prevalence of 20.3% was seen in the study population with female gender being more prone to the development of disease (p<0.001). Other factors of greater significance included body mass index (BMI), smoking, physical activity, intake of spicy foods, posture after meals, dinner to sleep time, non-steroidal anti-inflammatory drug (NSAID) intake and some underlying ailments like asthma and history of abdominal surgery.

Conclusion: The overall prevalence of GERD in Kashmiri community is 20.3% with females being more prone with a definite role of factors like BMI, smoking, physical activity, posture after meals, dinner to sleep time interval, intake of spicy foods, drugs and also the co-morbidities.

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References

Jo SJ, Kim N, Lim JH, Shin CM, Park YS, Lee DH, et al. Comparison of gastroesophageal reflux disease symptoms and proton pump inhibitor response using gastroesophageal reflux disease impact scale questionnaire. J Neurogastroenterol Motility 2013;19:61–9.

Eisen G. The epidemiology of gastroesophageal reflux disease: what we know and what we need to know. Am J Gastroenterol 2001;96:16-8.

Sleisenger and Fordtran: Textbook 9th Edition. Chapter 43; 2010. p. 707-15.

Nouraie M, Razjouyan H, Assady M, Malekzadeh R, Nasseri Moghaddam S. Epidemiology of gastroesophageal reflux symptoms in Tehran, Iran: a population-based telephone survey. Arch Iran Med 2007;10:289-94.

Wong WM, Lam KF, Lai KC, Hui WM, Hu WH, Lam CL, et al. A validated symptoms questionnaire (Chinese GERDQ) for the diagnosis of gastrooesophageal reflux disease in the Chinese population. Alimen Pharma Ther 2003;17:1407-13.

Hansen JM, Wildner Christensen M, Schaf falitzky de Muckadell OB. Gastroesophageal reflux symptoms in a danish population: a pro­spective follow-up analysis of symptoms, quality of life, and health-care use. Am J Gastroenterol 2009;104:2394-403.

Kumar S, Sharma S, Norboo T, Dolma D, Norboo A, Stobdan T, et al. Population-based study to assess prevalence and risk factors of gastroesophageal reflux disease in a high altitude area. Indian J Gastroenterol 2011;30:135-43.

Sharma PK, Ahuja V, Madan K, Gupta S, Raizada A, Sharma MP. Prevalence, severity, and risk factors of symptomatic gastroesophageal reflux disease among employees of a large hospital in northern India. Indian J Gastroenterol 2011;30:128-34.

Locke 3rd GR, Talley NJ, Fett SL, Zinsmeister AR, Melton 3rd LJ. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997;112:1448-56.

Dean BB, Crawley JA, Schmitt CM, Wong J, Ofman JJ. The burden of illness of gastroâ€oesophageal reflux disease: impact on work productivity. Alimen Pharma Ther 2003;17:1309-17.

Klauser AG, Schindlbeck NE, Müller Lissner SA. Symptoms in gastro-oesophageal reflux disease. Lancet 1990;335:205-8.

Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International gastroenterology surveillance study (DIGEST). Scandinavian J Gastroenterol 1999;34:20-8.

Ho KY, Lim LS, Goh WT, Lee JM. The prevalence of gastrooesophageal reflux has increased in Asia: a longitudinal study in the community. J Gastroenterol Hepatol 2001;16:132.

Wong WM, Lai KC, Lam KF, Hui WM, Hu WH, Lam CL, et al. Prevalence, clinical spectrum and health care utilization of gastroâ€oesophageal reflux disease in a Chinese population: a populationâ€based study. Alimenpharma Ther 2003;18:595-604.

Am Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. Am J Gastroenterol 2005r;100:747-53.

Valle C, Broglia F, Pistorio A, Tinelli C, Perego M. Prevalence and impact of symptoms suggestive of gastroesophageal reflux disease. Digest Dis Sci 1999;44:1848-52.

Moshkowitz M, Horowitz N, Halpern Z, Santo E. Gastroesophageal reflux disease symptoms: prevalence, sociodemographics and treatment patterns in the adult Israeli population. World J Gastroenterol: WJG 2011;17:1332.

Chen JH, Wang HY, Lin HH, Wang CC, Wang LY. Prevalence and determinants of gastroesophageal reflux symptoms in adolescents. J Gastroenterol Hepatol 2014;29:269-75.

Kumar S, Shivalli S. Prevalence, perceptions and profile of gastroesophageal reflux disease in a rural population of North Bihar. Nat J Commun Med 2014;5:214-8.

Moraes Filho JP, Chinzon D, Eisig JN, Hashimoto CL, Zaterka S. Prevalence of heartburn and gastroesophageal reflux disease in the urban Brazilian population. Arquivos de Gastroenterol 2005;42:122-7.

Ponce J, Vegazo O, Beltran B, Jiménez J, Zapardiel J, Calle D, et al. Prevalence of gastroâ€oesophageal reflux disease in Spain and associated factors. Alimen Pharma Ther 2006;23:175-84.

Li YM, Du J, Zhang H, Yu CH. Epidemiological investigation in outpatients with symptomatic gastroesophageal reflux from the department of medicine in zhejiang province, East China. J Gastroenterol Hepatol 2008;23:283-9.

Lazebnik LB, Masharova AA, Bordin DS, Vasil'ev I, Tkachenko EI, Abdulkhakov RA, et al. Multicentre study" Epidemiology of gastroesophageal reflux disease in Russia"(MEGRE): first results. Eksperimental'naia i klinicheskaia gastroenterologist. Exp Clin Gastroenterol 2009;6:4-12.

Pandeya N, Green AC, Whiteman DC, Australian Cancer Study. Prevalence and determinants of frequent gastroesophageal reflux symptoms in the Australian community. Dis Esoph 2012;25:573-83.

Diaz Rubio M, Moreno Elolaâ€Olaso C, Rey E, Locke GR, Rodriguezâ€Artalejo F. Symptoms of gastroâ€oesophageal reflux: prevalence, severity, duration and associated factors in a spanish population. Alimen Pharma Ther 2004;19:95-105.

Çela L, Kraja B, Hoti K, Toçi E, Muja H, Roshi E, et al. Lifestyle characteristics and gastroesophageal reflux disease: a population-based study in Albania. Gastroenterol Res Practice 2013. http://dx.doi.org/10.1155/2013/936792

Butt AK, Hashemy I. Risk factors and prescription patterns of gastroesophageal reflux disease: HEAL study in Pakistan. J Pak Med Assoc 2014;64:751-7.

El-Serag HB, Sonnenberg A. Opposing time trends of peptic ulcer and reflux disease. Gut 1998;43:327-33.

El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol 2005;100:1243-50.

Lagergren J, Bergström R, NyreÌn O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Annals Intern Med 1999;130:883-90.

Friedenberg FK, Xanthopoulos M, Foster GD, Richter JE. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol 2008;103:2111-22.

Orenstein SR, Shalaby TM, Barmada MM, Whitcomb DC. Genetics of gastroesophageal reflux disease: a review. J Ped Gastroenterol Nut 2002;34:506-10.

Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ. Risk factors associated with symptoms of gastroesophageal reflux. Am J Med 1999;106:642-9.

Wang JH, Luo JY, Dong L, Gong J, Tong M. Epidemiology of gastroesophageal reflux disease: a general population-based study in Xi’an of Northwest China. World J Gastroenterol 2004;10:1647-51.

Chen T, Lu M, Wang X, Yang Y, Zhang J, Jin L, et al. Prevalence and risk factors of gastroesophageal reflux symptoms in a Chinese retiree cohort. BMC Gastroenterol 2012;12:161.

Yönem O, Sivri B, Ozdemir L, Nadir I, Yuksel S, Uygun Y. Gastroesophageal reflux disease prevalence in the city of Sivas. Turkish J Gastroenterol 2013;24:303-10.

Published

01-08-2018

How to Cite

Koul, R. K., S. Parveen, P. Lahdol, P. S. Rasheed, and N. A. Shah. “PREVALENCE AND RISK FACTORS OF GASTROESOPHAGEAL REFLUX DISEASE (GERD) IN ADULT KASHMIRI POPULATION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 10, no. 8, Aug. 2018, pp. 62-66, doi:10.22159/ijpps.2018v10i8.25894.

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