BRIEF REVIEW OF SPECTROPHOTOMETRIC METHODS FOR THE DETECTION OF TETRACYCLINE ANTIBIOTICS
Keywords:
Tetracylcine, Spectrophotometric methods, Antibiotics, wavelength, Oxidizing agentsAbstract
Antibiotics are one of the most common pharmaceutical products, used for the treatment of bacterial ,fungal and parasitic infections. Among antibiotics, tetracyclines are extensively used in both human and animal welfare. Hence the monitoring and estimation of the levels of tetracycline in pharmaceutical products and effluents have become a necessity for researchers and industries. Current methods for estimation are based on high-level technologies ,and suffer from several disadvantages such as being time consuming, expensive and require extensive training to operate.Much focus has been made on the development of simple ,quick and inexpensive methods that can be used in a routine manner. Most methods use either redox reaction of the tetracycline using an oxidizing agent or the use of polyvalent cations for chelation and complexometric reactions. Spectrophotometric methods for detection of antibiotics are simple but rare. The objective of this review article is to present an insight into the various spectrophotometric methods available for the detection of tetracycline, with data regarding the reagents, wavelength used for the measurement and optimum concentration range applicable for each method.
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References
Brodersen DE. The structural basis for the action of the antibiotics tetracycline, pactamycin, andhygromycin B on the 30S ribosomal subunit. Cell 2000;103:1143–54.
Ianchopra , Marilyn Roberts. Tetracycline antibiotics: mode of action, applications,molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 2001;232–60.
Lauren B, Pickens, Yi Tang, Oxytetracycline Biosynthesis. J Biol Chem 2010;285:27509–15.
Connamacher RH, Mandel HG. Binding of tetracycline to the 30 S ribosomes and to polyuridylic acid. Biochim Biophys Acta 1968;166(2):475–86.
Duggar BM. Aureomycin: a product of the continuing search for new antibiotics. Ann NY Acad Sci 1948;51(2):177–81.
Finlay AC, Hobby GL, Pan SY, Regna PP, Routein JB, Seeley DB, et al. Terramycin, a new antibiotic. Sci 1950;111:85.
ZakeriB, Wright GD. Chemical biology of tetracycline antibiotics. Biochem Cell Biol 2008;86:124-36.
Hochstein FA, Stephens CR, Conover LH, Regna PP, Pasternack R, Gordon PN, et al. The structure of terramycin. J Am Chem Soc 1953;75:5455–75.
Nelson ML, Park BH, Levy SB. Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria. J Med Chem 1994;37:1355–61.
Oliva B, Chopra I. Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes. Antimicrob Agents Chemother 1992;36:876–8.
Chopra I. Tetracycline analogs whose primary target is not the bacterial ribosome. Antimicrob Agents Chemother 1994;38:637–40.
Calvin M, Wilson KW. Stability of chelate compounds. J Amer Chem Soc 1945;67:2003-7.
Brody TM, Hurwitz R, Bain JA. Magnesium and the effect of the tetracycline antibiotics on oxidative processes in mitochondria. Antibiot Chemother 1954;4:864-70.
Avtalion RR, Ziegler-Schlomowitz R, Pearl M, Wojdani A, Sompolinsky D. Depressed resistance to tetracycline in Staphylococcus aureus. Microbios 1971;3(10):165–80.
Albert A, Rees CW. Avidity of the tetracyclines for the cations of metals. Nature 1956;177:433-4.
Laskin AI. Tetracyclines, in Antibiotics I, Mechanism of action, D. Gottlieb and P. D. Shaw (ed.). Springer-Verlag: New York; 1967:331-59.Rafal Klajn. Chemistry and chemical biology of tetracyclines http: //www.chm.bris.ac. uk/motm/ tetracycline/ tetracycline.htm.
Jose LR, Flavio CBF, Mayara SR, Helena RP, Leonardo Pezza. A simple spectrophotometric method for the determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T. Eclet QuÃm 2010;35.
Kasim MH, Al-Abbasi. Spectrophotometric determination of tetracycline by azo dye formation with diazotised p-nitroaniline-application to pharmaceutical preparations and biological fluids. J Raf Sci 2009;20(1):61-74.
Salah M. Sultan Spectrophotometric determination of tetracycline with sodium molybdate. Analyst 1986;111:97-9.
Salah MS, Ibrahim ZA, Nawal A. Complexometric-spectrophotometric assay of tetracyclines in drug formulations. Talanta 1988;35(5):375-8.
Saha U. Colorimetric determination of tetracycline derivatives in pharmaceutical preparations. J Assoc Off Anal Chem 1989;72(2):242-4.
Nagwa HSA, Ebtisam El-Hasheme, El-EnanyN, Belal F. Kinetic spectrophotometric method for the determination of tetracycline hydrochloride in pharmaceutical formulations. Archives Appl Sci Res 2009;1(2):1-11.
Fahelelbom KMS. Analysis of certain tetracyclines and oxytetracyclines through charge transfer complexation. Am J Pharmacol Toxicol 2008;3:212-8.
Saha U, Sen AK, Das TK, Bhowal SK, Spectrophotometric determination of tetracyclines in pharmaceutical preparations, with uranyl acetate. Talanta 1990;37(12):1193-6.
Abdel-Khalek MM, Mahrous MS. Spectrophotometric determination of tetracyclines and cephalosporins with ammonium vanadate. Talanta. 1983;30(10):792-4.
Prasad ARG, Rao VS. Spectrophotometric methods for the microdetermination of Oxytetracycline and Hostacycline. Sci World J 2010;5.