SYNTHESIS AND CHARACTERIZATION IN VITRO ANTIMICROBIAL AND CYTOTOXICITY TESTING OF OXALIC ACID-DERIVED CADMIUM CHELATING AGENTS
DOI:
https://doi.org/10.22159/ijpps.2018v10i7.26034Keywords:
Na4Cd2 (C2O4) 44H2O crystal growth, Single crystal XRD, FTIR, UV, Biological activity studiesAbstract
Objective: The aim of this study is to investigate the growth, structure, spectral, solubility and biological activity of sodium cadmium oxalate dehydrate (NaCdOx) and cadmium oxalate trihydrate (CdOx) crystals prepared by a single diffusion method in the silica gel medium.
Methods: The present crystals were grown using single diffusion methods and tested for XRD, UV absorption (190 to 1100 mm) and solubility (distilled water at 20-29 °C) studies. The antimicrobial efficacy of the grown samples at various concentrations (25, 50, 75 and 100 μg/ml) was studied against Streptococcus, (G+Ve), Pseudomonas aeruginosa (G-Ve) and Candida albicans (antifungal). The cytotoxicity evolution was carried out against human cervical cancer cell line (HeLa) using MTT assays.
Results: The existing single crystals were successfully grown by silica gel technique. The solubility of sodium cadmium oxalate dehydrate (NaCdOx) was moderately good in deionized warm water. The FTIR spectral studies confirmed the chelating bands of the present samples and UV spectra showed the better the optical conductivity of as-grown crystals. The complexes showed good antimicrobial activity against all tested microbial strains and they exhibited a decrease in cytotoxicity activity.
Conclusion: The gel method was suitable to grow metal complexes of legend crystals. The modification of structural properties of cadmium oxalate trihydrate (CdOx) by sodium doping was much improved the solubility, anticancer, antimicrobial activity and polarization by the high optical conductivity of sodium cadmium oxalate dehydrate (NaCdOx) compound. Hence sodium cadmium oxalate dehydrate (NaCdOx) might be a candidate for biomedical applications.
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Brown GE, Foster AL, Ostergren JD. Mineral surfaces and bioavailability of heavy metals: a molecular-scale perspective. Proc Natl Acad Sci 1999;96:3388-95.
Chojnacka K, Chojnacki A, Gorecka H, Gorecki H. Bioavailability of heavy metals from polluted soils to plants. Sci Total Environ 2005;337:175-82.
Hodgkin Son. A Oxalic acid in biology and medicine. Febs Lett 1977;101:1-326.
Jennifer Prescott. Oxalic acid-the cure for cancer. Ezines Articles India: Ezines Publishers; 2008.
Atheer AM, Abdulqader MA, Mohammed Mosa Jafaar. Studying of transition metal complexes containing oxalate ion with antibacterial activity. Int J Sci Eng Res 2015;6:855-67.
Al-Jibouri MNA. Template synthesis of metal complexes from domino pyridine and dihydroquinoxalin-2, 3-dione. Eur Chem Bull 2014;3:384-9.
Tapaha G Roy, Saroj KS Hazari, Dong I Kim. Synthesis, electrolytic behavior and antimicrobial activities. Cadmium complexes of isomers of 3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane. J Coord Chem 2007;60:1567-78.
Montazerozohori M, Yadegari S, Naghiha A. Synthesis, characterization, electrochemical behavior and antibacterial/antifungal activities of [Cd (L) X2] complexes with a new schiff base ligand. Serb Chem Soc 2014;79:793–804.
Herdwiani W, Soemardji AA, Elfahmi I, Tan MI. A review of cinnamon as a potent anticancer drug. Asian J Pharm Clin Res 2016;9:8-13.
Patil NR, Gadagil S. Performance of chrom agar medium and conventional methods for detection of methicillin-resistant Staphylococcus aureus. Asian J Pharm Clin Res 2016;9:136-9.
Parekh BB, Vyas PM, Sonal R Vasant, Joshi MJ. Thermal, FT–IR and dielectric studies of gel grown sodium oxalate single crystals. Bull Mater Sci 2008;31:143–7.
Shedam MR, Venkateswara Rao A. Effect of temperature on the nucleation and growth of cadmium oxalate single crystals in silica gels. Mater Chem Phys 1998;52:263-6.
Anandha Babu G, Sreedhar S, Venugopal Rao S, Ramasamy P. Synthesis, growth, structural, thermal, linear and nonlinear optical properties of a new organic crystal: dimethyl ammonium picrate. J Cryst Growth 2010;312:1957-62.
Rui-Qin Zhong, Ru-Qiang Zou, Daya S Pandey, Tetsu Kiyobayashi, Qiang Xu. A novel 3D micro porous metal-organic framework of cadmium (II) oxalate with diamondoidnetwork. Inorg Chem Commn 2008;11:951-3.
Dwi Utami, Ilma Nugrahani, Slamet Ibrahim. Mefenamic acid-nicotinamide co-crystal synthesized by using melt crystallization method and its solubility study. Asian J Pharm Clin Res 2017;10:135-9.
Bhattacharjee R, Jain YS, Raghybanshi G, Bist Laser HD. Raman and infrared spectra of rochelle salt crystals. J Raman Spectrosc 1988;19:51-8.
Brown less NJ, Edwards DA, Mohan MF. Some complexes derived from zinc salicylate or 3, 5-di-tert-butylsalicylate. the crystal structure of (2, 2′-bipyridyl) (methanol) (o-salicylato) (o, o′-salicylato) zinc. Inorg Chim Acta 1999;287:89-94.
Kokkonen P, Lajunen LHJ, Jaakkola A, Ruotssalainen H. Kinetic and mechanistic studies on the decomposition of some hydrous iron (II) salicylate complexes. Thermochim Acta 1984;79:289-98.
Dhanaraj PV, Rajesh NP, Vinitha G, Bhagavannarayana G. Crystal structure and characterization of a novel organic optical crystal: 2-aminopyridinium trichloroacetate. Mater Res Bull 2011;46:726-31.
Mahmood A, Abdulqader M, Saffa Raheem Mahmood, Mohammed MosaJafaar, Anaam Mahmood Abid. Studying of transition metal complexes containing oxalate ion with antibacterial activity. Int J Sci Eng Res 2015;6:855-67.
Abou-Hussein AA, Nelly HM, Linert W. Synthesis, solvatochromism, and antimicrobial activities of new binuclear copper (II) mixed-ligand complexes in a ternary system with β-diketones and diamine ligands. J Coord Chem 2011;64:2592-605.
Abu-Hussein AA, Linert W. Redox, thermodynamic and spectroscopic of some transition metal complexes containing heterocyclic Schiff base ligands. Spectrochim Acta Part A 2009;74:214-23.
Tweedy BG. Plant extracts with metal ions as potential antimicrobial agents. Phytopatology 1964;55:910-8.
Jeyaprakash Dharma-Raja, Paramasivam Subarea, Thirugnanasam, Esakkidurai, Sutha Shobana. Coordination behavioral and bio-potent aspects of Ni (II) with 2-aminobenzamide and some amino acid mixed ligands–part II: synthesis, spectral, morphological, and pharmacological and DNA interaction studies. Spectrochimica Acta Part A 2014;132:604-14.
Singh Jadon SC, Gupta N, Singh RV. Synthetic and biochemical studies of some hydrazine carbodithioic acid derivatives of dioxomolybdenum (VI). Indian J Chem 1995;34A:733-6.
Zahid H, Chohan M. Ni (II), Cu (II) And Zn (II) metal chelates with some thiazole derived Schiff-bases. Their synthesis, characterization and bactericidal properties. J Metal-Based Drugs 1999;6:75-80.
Suresh Kumar S, Athimoolam S, Sridhar B. Hydrogen bonding motifs, spectral characterization, theoretical computations and anticancer studies on chloride salt of 6-mercaptopurine: an assembly of corrugated lamina shows enhanced solubility. J Mol Struct 2015;1098:332-41.
Tamara Todorovic, Alessia Bacchi, Nenad Juranic, Katarina Andelkovic. Synthesis and characterization of novel Cd (II), Zn (II) and Ni (II) complexes with 2-quinolinecarboxaldehyde selenos emicarbazone. Crystal structure of bis (2-quinolinecarboxaldehyde seleno semicarbazonato) nickel (II). Polyhedron 2007;26:3428-36.
Jeena K, Liju VB, Kuttan R. Antitumor and cytotoxic activity of ginger essential oil (Zingiber officinale roscoe). Int J Pharm Pharm Sci 2015;7:341-4.
Vinod Singh, Pooja Singh, Ashish K Singh. Synthesis, structural and corrosion inhibition studies on cobalt (II), nickel (II), copper (II) and zinc (II) complexes with 2-acetylthiophene benzoyl hydrazine. Inorg Chim Acta 2011;379:56-63.
Kiran Singh, Manjeet Singh Barwa, Parikshit Tyagi. Synthesis and characterization of cobalt (II), nickel (II), copper (II) and zinc (II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1, 2, 4-triazine. Eur J Med Chem 2007;42:394-402.
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