EVALUATION AND OPTIMIZATION OF LEPIDIUM SATIVUM SEED MUCILAGE AS BINDER IN TABLET FORMULATION
Keywords:
Lepidium sativum mucilage, Binder, Natural excipientsAbstract
Objective: The study elaborates isolation of mucilage from Lepidium sativum seeds and explores it as a tablet binder.
Methods: The mucilage from seed was extracted by precipitation of soaked and blended seed in acetone. The mucilage was evaluated for its binding properties in tablets prepared by wet granulation and direct compression method. The prepared tablets were evaluated for hardness, thickness, friability, disintegrating time and in-vitro drug release and compared with established binder like starch, PVP K-30, HPMC, MCC.
Results: The results of isolated mucilage from Lepidium sativum seeds as a binder were very promising. The results indicated that mucilage is required in concentration as low as 2% for wet granulation and 4% for direct compression to give equivalent binding effect.
Conclusion: Lepidium sativum seed mucilage [LSM] shows promising potential for its application as a binder in the tablet formulation. Low concentration of LSM as binder would also help to reduce cost of formulation.
Downloads
References
Rudnic EM, Schwarth JD. Remington: The science and practice of pharmacy. 20th ed. USA: Lippincott willium and wilkins; 2000.
Evans WC. Trease and Evans pharmacognosy. 16th ed. London: Saunders Elsevier; 1983.
Shrinivas K, Prakesh K, Kiran HR, Prasad PM. Study of Ocimum basilicum and Plantago ovate as disintegrants in the formulation of dispersible tablets. Indian J Pharm Sci 2003;65:180-3.
Verma PRP, Razdan B. Studies on Leucaena leucocephala seed gum: emulsifying properties. JSIR 2003;62:198-206.
Ibezim C, Khanna M, Sing S. A study of suspending properties of Anacardium accidentale gum. JSIR 2000;59:1038-43.
Guwthamarajan K, Kulkarni TG, Vijayakumar RS, Suresh B. Evalution of Borassus flabellier mucilage as gelling agent. Indian Drugs 2003;40:640-4.
Alonso-Sande M, Teijeiro-Osorio D, Remunan-Lopez C, Alonso M. Glucomannan, a promising polysaccharide for biopharmaceutical purposes. Eur J Pharm Biopharm 2009;72:453-62.
Avachat AM, Dash RR, Shrotriya SN. Recent investigation of plant based gums, mucilages and resins in novel drug delivery system. IJPR 2011;45:86-99.
Dharmendra S, Surendra JK. Natural excipient–a review. IJPBA 2012;3:1028-34.
Tiwari PN, Kulmi GS. Performance of Chandrasur (Lepidium sativum) under different levels of nitrogen and phosphorus. J Med Aromatic Plant Sci 2004;26:479-81.
Nandkarni KM. The Indian medica. 2 nded. Mumbai: dhootapa–peshwar prakashan; 1954.
Chopra R, Nayar L, Chopra L. Glossary of Indian medicinal plants. New Delhi: council of scientific and industrial research; 1986.
Kamble MS, Mendake SD, Dange SM, Bhalerao KK, Aute PP, Chaudhari PD. Evalution of binding property of Ocimum tenuiflorumlinn. Seed isolated by defatting method. JBPR 2012;1:22-7.
Waghmare AS, Waghmare PD, Gramourohit ND, Kodag PP. Evalution of flax mucilage as a binder in tablet formulations. IJUPBS 2012;2:97-102.
Patel N. Pandya TP, Shah VN, Mahajan AN. Isolation of mucilage from Cydonia vulgaris pers. Seeds and its evalution as a tablet binder. Int J Pharm Pharm Sci 2011;3:351-5.
Ghule BV, Darwhekar GD, Jain DK, Yeole PG. Evalution of binding properties of Eulophia campestris wall Mucilage. Indian J Pharm Sci 2006;68:566-9.
Selvi RS, Gopalakrashanan S, Ramajayam M, Soman R. Evalution of mucilage of Prosopis julifloraas tablet binder. Int J Pharm Pharm Sci 2010;2:157-60.
Karazhiyan H, Razavi SMA, Phillips OG, Fang Y, Al-Assaf S, Nishinari K. Physiochemical aspect of hydrocolloid extract from the seeds of Lepidium sativum. Int J Food Sci Technol 2011;46:1066-72.
Kokare C. Pharmaceutical microbiology experiments and technique-3rded. Pune: career publication; 2008.
Lachman L, Liberman H. The Theory and Practice of Industrial Pharmacy. 3rd ed. Bombay: Varghese Publishing House; 1991.
Aulton M. The Design and Manufacturing of Medicine. 3rd ed. UK: An Imprint of Harcourt Publisher; 2007.
Thube R, Gothoskar A, Shaikh S. Study of potential of natural polymers as formulation component for the development of sustained release matrix tablet. IJPRD 2011;3:15-22.
Efentakis M, Koutlis A. Release of Furosemide from multiple unit and single unit preparations containing different viscosity grades of sodium alginate. Pharm Dev Tecnol 2001;6:91-8.
Kumar R, Patil S, Patil MB, Patil SR, Paschapur MS. Isolation and evaluation of disintegrant properties of fenugreek seed mucilage. Int J Pharm Tech Res 2009;1:982-96.
Indian Pharmacopoeia, Vol-I (A-O), Ministry of Health and Family Welfare, Govt. of India. New Dehli: Controller of Publications; 1996.
Shahi SR, Agrawal GR, Rathi PV, Shinde NG, Somani VG, Mahamuni SB, et al. Development and validation of UV spectrophotometric method for the determination of etoricoxib in bulk and tablet formulation. Rasayan J Chem 2008;1:390-4.
United States Pharmacopoeia – National Formulary, 28thed. 2005.
Rohokale SS, Dhanorkar YD, Pahuja V, Kulkarni GT. Characterization of selected polysaccharide hydrogels as pharmaceutical excipients. J Chronother Drug Deliv 2012;3:41-53.
Fujio Y, Hayashi N, Hayakawa I. Effect of moisture content on flow behavior of molten soy-protein isolated under an elevated temperature. Int J Food Sci Tech 2007;26:45-51.