• M. M. Pathan Department of Pathology, College of Veterinary & Animal Sciences, (MAFSU, Nagpur) Udgir 413517 (M.S.) INDIA
  • M. A. Khan Department of Pathology, College of Veterinary & Animal Sciences, (MAFSU, Nagpur) Udgir 413517 (M.S.) INDIA
  • A. P. Somkuwar Department of Pathology, College of Veterinary & Animal Sciences, (MAFSU, Nagpur) Udgir 413517 (M.S.) INDIA
  • N. Z. Gaikwad Department of Pathology, College of Veterinary & Animal Sciences, (MAFSU, Nagpur) Udgir 413517 (M.S.) INDIA


M emarginata, Hepatoprotective, Paracetamol toxicity, Histopathology


Objective: To study the hepatoprotective activity of ethanol extract of Maytenus emarginata against Paracetamol induced toxicity in male Wistar rats.

Methods: The liver injury was induced by Paracetamol @ 500 mg/kg B.W. orally for entire duration of study. The rats were divided in six groups. Rats of Group C1 served healthy control received no treatment, Group C2 served vehicle control received 1ml of Propylene glycol orally. C3 group rats acted as toxic control and received Paracetamol orally @ 500 mg/kg B.W. of rats. Group T1, T2 and T3 received Silymarin @ 100 mg/kg B.W., Maytenus emarginata extract @ 100 mg/kg B.W. and Maytenus emarginata extract @ 150 mg/kg B.W. orally of rats respectively along with Paracetamol @ 500 mg/kg B.W. of rats orally for 28 days.

Results: Histopathological examination and elevation of biochemical marker enzymes ALP, ALT and AST along with decreased levels of serum total protein and serum albumin confirmed the liver injury produced by Paracetamol. Treatment of rats with Maytenus emarginata extract showed significant reduction in levels of serum ALP, ALT and AST with elevation of serum protein and albumin near to normal in a dose dependant manner. Dose of 150 mg/kg B.W. of Maytenus emarginata extract showed significant effects comparable to the effects showed by standard treatment drug Silymarin @ 100 mg/kg B.W. orally.

Conclusion: Maytenus emarginata ethanol extract possess potent hepatoprotective effect.


Download data is not yet available.


Kshirsagar AD, Mohite R, Agarwal AS, Suralkar UR, Asian J. Hepatoprotective medicinal plants of Ayurveda-A review. Pharm Clin Res 2011;4

Radostitis OM, Gay CC, Hinchiff KW, Constable PD. A textbook of the diseases of cattle, horses, and goats. 10th edn S Baillere Tindall p 273 2007.

Payasi A, Chaudhary M, Singh BM, Gupta A, Sehgal R. Sub-acute toxicity studies of Paracetamol infusion in albino Wistar rats. IJPSRD 2010;2

Garba SH, Sambo N, Bala U. The effect of the aqueous extract of Kohautia grandiflora on paracetamol-induced liver damage in albino rats. Nigerian journal of physiological sciences:official publication of the Physiological Society of Nigeria 2009;24(1):17-23.

Anjaria J., Minoo P. and Dwivedi S. Ethnovet Heritage Indian Ethno-Veterinary Medicine an overview, Pathik Enterprise, Ahmedabad, 2002. p. 242.

Winjerantne DBT, Kumar V, Uvais M, Sultanbawa S, Balsubramaniam S. Triterpenes from Gymnosporia emarginata. Phytochemistry 1982;21(9): 2422-2423.

Parmar SR, Dave GS, Patel HV, Kalia K. Hepatoprotective value of some plant extract against carbon tetra chloride toxicity in male rats. J Cell Tissue Resarch 2009; 9(1): 1773-1743.

Parmar SR, Varshambhai PH, Kalia K. Hepatoprotective activity of some plant extract against Paracetamol induced hepatotoxicity in rats. J Herbal Med Toxicol 2010; 4(2): 101-106.

Culling C.F.A. A Hand Book of Histopathological Techniques, 3rd edn., Butter Worth and Co. Ltd., 1974. p. 29-221.

Muthulingam M, Mohandas P, Indra N, Sethupathy S. Antihepatotoxic efficacy of Indigofera tinctora (Linn.) on Paracetamol induced liver damage in rats. Int J Pharm Biomed Res 2010;1(1): 13-18.

Sandhu NS, Chopra D, Kaur S. Amelioration of Paracetamol induced hepatotoxicity by a protein isolated from the leaves of the herb Cajanusa cutifolius linn. Int J Pharmacy Pharma Sci 2010; 2(3): 75-80.

Adeneye AA, Olagunju JA, Elias SO, Olantunbosun DO, Mustafa AO, Adeshile OI, et al. of Applied Res. in Natural Products 2008;12008; 1(3): 29-42.

Chaterjee TK. Medicinal plants with hepatoprotective properties. In Herbal Options 3rd Edn Books and Allied P Ltd Calcutta. 2000; p. 135.

Desai S, Gavitre B, Gite M, Ahmad A, More Y. Comparative evaluation of hepatoprotective activity of polyherbal formulations PHF-A and PHF-B in rats. Scholar research library 2010; 2(3): 326-334.

Kanchana N, Sadiq AM. Hepatoprotective effect of Plumbago zeylanica on Paracetamol induced liver toxicity in rat. Int J Pharm Pharm Sci 2011; 3(1): 151-154.

Haldar KP, Biswas M, Bhatacharya S, Karan TK, Ghosh AK. Hepatoprotective activity of Dregea volubilis fruit against Paracetamol induced liver damage in rats. Ind J Pharm Edu Res 2012; 46(1): 17-22.

Zakaria ZA, Rofiee MS, Somchit MN, Zuraini A, Sulaiman MR, Teh LK, et al. Hepatoprotective activity of dried-and fermented-processed virgin coconut oil. Evidence-based complementary and alternative medicine: 2011: 1-8.

Yadav NP, Chanda D, Chattopadhyay SK, Gupta AK, Pal A. Hepatoprotective Effects and Safety Evaluation of Coumarinolignoids Isolated from Cleome viscosa Seeds. Indian J Pharm Sci 2010;72(6):759-765.

Kumar RM, Fasalurahaman OM, Tamizmane T, Niyas H, Satyakumar B, Phaneendra P. et. al. Evaluation of hepatoprotective activity of Asparagus vacmosusroot against paracetamol-induced acute liver injury in rats. Pharmacologyonline 2011; 1: 1059-1066.

Dasgupta B, Kalita JC, Chaudhary A, Kotoky J, J. Hepatoprotective activity of Nelsonia canescens (Lin.) spreng on acute hepatotoxicity induced by Paracetamol. Int Pharm Sci 2012; 4(1): 107-112

Boyd EM, Bereczky GM. Liver necrosis from paracetamol. Br J Pharmacol Chemother 1966; 26: 606-614.

Rao GMM, Pushpangadan P, Shirwaikar A. Hepatoprotective activity of Nelumbo nucifera Geartn. Flower An Ethnopharmacological study Acta Pharmaceutica Turcica 2005; 47: 79-88.

Nema AK, Agarwal A, Kashaw V. Hepatoprotective activity of Leptadenia reticulata stems against carbon tetrachloride-induced hepatotoxicity in rats. Indian J Pharmacol 2011;2 (2): 360-374.

Tanwar M, Sharma A, Swarnkar KP, Singhal M, Yadav K. Antioxidant ads hepatoprotective activity of Trichosanthes dioica Roxb. on Paracetamol induced toxicity IJPSR 2011;2 (1): 110-121.

Patel PB, Patel TK, Shah P, Baxi SN, Sharma HO, Tripathi CB. Protective Effect of Ethanol Extract of Gymnosporia montana (Roth) Bemth. in Paracetamol-induced Hepatotoxicity in Rats. Indian J Pharm Sci 2010;72 (3): 392-396.

Gite VN, Pokharkar RD, Chopade VV, Takate SB. Hepato-protective activity of Enicostemma axillare in Paracetamol induced hepato-toxicity in albino rats. IJPLS 2010;1

Manivannan E, Rajaram S, Kothai R, Arul B, Jayakar B. Effect of Calotropis procera Linn. against Paracetamol induced hepatotoxicity in rats Int J Res Pharma Biomed Sci 2011; 2(2): 710-703.

Eimendoki DG, Uwakwe AA, Ibe GO, Nigerian J. Protective effect of Garcinia kola seed and honey mixture against Paracetamol-induced hepatotoxicity in rats. Biochem Mol Bio 2010; 25(2): 86-90.

Kangralkar VA, Patil SD, Nadegao VS, Burli SC. bandivadekar R. M and Hepatoprotective activity of Feronia elphantum fruit extract against Paracetamol induced hepatic damage in Wistar rats Int J Pharm App 2010;1:29- 46-49.



How to Cite

Pathan, M. M., M. A. Khan, A. P. Somkuwar, and N. Z. Gaikwad. “HEPATOPROTECTIVE ACTIVITY OF MAYTENUS EMARGINATA AGAINST PARACETAMOL INDUCED LIVER INJURY IN MALE WISTAR RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 320-3, https://journals.innovareacademics.in/index.php/ijpps/article/view/2787.



Original Article(s)