HEPATOPROTECTIVE ACTIVITY OF MAYTENUS EMARGINATA AGAINST PARACETAMOL INDUCED LIVER INJURY IN MALE WISTAR RATS
Keywords:
M emarginata, Hepatoprotective, Paracetamol toxicity, HistopathologyAbstract
Objective: To study the hepatoprotective activity of ethanol extract of Maytenus emarginata against Paracetamol induced toxicity in male Wistar rats.
Methods: The liver injury was induced by Paracetamol @ 500 mg/kg B.W. orally for entire duration of study. The rats were divided in six groups. Rats of Group C1 served healthy control received no treatment, Group C2 served vehicle control received 1ml of Propylene glycol orally. C3 group rats acted as toxic control and received Paracetamol orally @ 500 mg/kg B.W. of rats. Group T1, T2 and T3 received Silymarin @ 100 mg/kg B.W., Maytenus emarginata extract @ 100 mg/kg B.W. and Maytenus emarginata extract @ 150 mg/kg B.W. orally of rats respectively along with Paracetamol @ 500 mg/kg B.W. of rats orally for 28 days.
Results: Histopathological examination and elevation of biochemical marker enzymes ALP, ALT and AST along with decreased levels of serum total protein and serum albumin confirmed the liver injury produced by Paracetamol. Treatment of rats with Maytenus emarginata extract showed significant reduction in levels of serum ALP, ALT and AST with elevation of serum protein and albumin near to normal in a dose dependant manner. Dose of 150 mg/kg B.W. of Maytenus emarginata extract showed significant effects comparable to the effects showed by standard treatment drug Silymarin @ 100 mg/kg B.W. orally.
Conclusion: Maytenus emarginata ethanol extract possess potent hepatoprotective effect.
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