DOES LOW DOSE OF PIPER NIGRUM EXTRACT EXERT ANTI-OBESITY ACTIVITY?

IRAM NAZISH; FAIZA SHAIKH; GAURANG SAWANT

doi:10.22159/ijpps.2020v12i5.27942

Authors

IRAM NAZISH Department of Pharmaceutical Sciences, CMR College of Pharmacy, Hyderabad, Telangana, India http://orcid.org/0000-0002-1038-3557
FAIZA SHAIKH Department of Pharmacology, H K College of Pharmacy, Oshiwara, Mumbai, India
GAURANG SAWANT Department of Pharmacology, H K College of Pharmacy, Oshiwara, Mumbai, India

DOI:

https://doi.org/10.22159/ijpps.2020v12i5.27942

Keywords:

Piper nigrum, High fat diet, Obesity, Insulin, Lipid

Abstract

Objective: To evaluate anti-obesity effect of aqueous P. nigrum extract in a murine model of high-fat diet (HFD) induced obesity.

Methods: Male Wistar rats were fed with a high-fat diet (HFD) (20g/day/rat) for a period of 50 d to induce obesity. Aqueous P. nigrum extract (20 mg/kg) administered orally to high-fat diet (HFD) fed rats from 8^th day to 50^th day (total 42 d). The parameters like gain in body weight, serum lipids, insulin and leptin were measured.

Results: The rats treated with extract showed a significant reduction in body weight gain, serum insulin, leptin, lipids as compared to rats fed with only a high-fat diet (HFD). In addition, the extract-treated group showed a considerable rise in high-density lipoprotein (HDL-C) level (29.61±7.68 mg/dl) as compared to the control group (23.23±9.69 mg/dl).

Conclusion: The results indicate that aqueous P. nigrum extract possess the potential to reduce obesity markers in a high-fat diet (HFD) fed rats.

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Author Biographies

IRAM NAZISH, Department of Pharmaceutical Sciences, CMR College of Pharmacy, Hyderabad, Telangana, India

ASSOCIATE PROFESSOR

PHARMACOLOGY

FAIZA SHAIKH, Department of Pharmacology, H K College of Pharmacy, Oshiwara, Mumbai, India

Assistant Professor

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