PHYSICOCHEMICAL CHARACTERISTICS OF RASAMANIKYA-AN AYURVEDIC ARSENICAL FORMULATION

Arjun Singh; Sarada Ota; Narayanan Srikanth; Galib R; Sreedhar Bojja; Kartar Singh Dhiman

doi:10.22159/ijpps.2019v11i5.29429

Authors

Arjun Singh Council for Research in Ayurvedic Sciences, New Delhi
Sarada Ota Council for Research in Ayurvedic Sciences, New Delhi
Narayanan Srikanth All India Institute of Ayurveda, Sarita Vihar, New Delhi
Galib R All India Institute of Ayurveda, Sarita Vihar, New Delhi
Sreedhar Bojja Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad
Kartar Singh Dhiman Council for Research in Ayurvedic Sciences, New Delhi

DOI:

https://doi.org/10.22159/ijpps.2019v11i5.29429

Keywords:

Physico-chemical, Rasamanikya, Ayurvedic arsenical

Abstract

Objective: The objective of this study was standardization and Chemical characterization of rasamanikya prepared as per standard operating procedures (SOP) mentioned in the classical text.

Methods: Rasamanikya was prepared by putting churnodaka shodhita haratala (Orpiment-As₂S₃) between two abhraka (white mica) sheets which are heated for a while to obtain a red colored finished product. The Ayurvedic specifications for the analysis of rasamanikya were performed through qualitative and quantitative analysis. Physicochemical analysis, assay of elements by atomic absorption spectrometer (AAS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES) were carried out and some other tests such as x-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS) and energy dispersive x-ray analyzer (EDAX) were also performed to ensure the quality of the drug.

Results: In the finished drug Arsenic and Sulphur are present in the form of As₄S₄, As₂S₃, As₂S₅. On the basis of XPS survey scans, scanning electron microscopy-energy dispersive x-ray analyzer (SEM-EDAX) and carbon, hydrogen, nitrogen, sulphur (CHNS) analysis the Arsenic to Sulphur (As to S) ratio is thus standardized as 39-47: 53-61. In addition to this powder, XRD shows a major conversion into an amorphous phase.

Conclusion: The results could be used to lay down a new set of pharmacopoeial standards for the preparation of rasamanikya for getting optimal efficacy of medicine. Therefore, the information will help the Scientists and Researchers to build comprehensive standards, to screen the compounds responsible for different bioactivities, and to elucidate the molecular mechanism of action.

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Author Biographies

Arjun Singh, Council for Research in Ayurvedic Sciences, New Delhi

RESEARCH OFFICER, CHEMISTRY, TECHNICAL SECTION

Sarada Ota, Council for Research in Ayurvedic Sciences, New Delhi

RESEARCH OFFICER, AYURVEDA, TECHNICAL SECTION

Narayanan Srikanth, All India Institute of Ayurveda, Sarita Vihar, New Delhi

Deputy Director General, Technical Section

Galib R, All India Institute of Ayurveda, Sarita Vihar, New Delhi

ASSOCIATE PROFESSOR, Department of Rasa Shashtra and Bhasijaya Kalpana

Sreedhar Bojja, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad

Sr. Principal Scientist

Kartar Singh Dhiman, Council for Research in Ayurvedic Sciences, New Delhi

Director General

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