ENHANCING SOLUBILITY AND DISSOLUTION OF FENOFIBRATE BY SPRAY DRYING TECHNIQUE
Keywords:
Spray drying, Microspheres, Fenofibrate, Pluronic F-127, Solubility, DissolutionAbstract
Objective: Fenofibrate, a hypolipidemic drug agent, exhibits poor water solubility and dissolution. Thus, the aim of the present study was to improve the solubility and dissolution rate of Fenofibrate by preparing microspheres by spray drying technique using Pluronic F-127.
Methods: Fenofibrate Microspheres containing different ratios of Pluronic F-127 were produced by spray drying using Chloroform as solvent to enhance solubility and dissolution rate. The prepared formulations containing different ratios of drug and Pluronic F-127were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared spray dried microspheres was compared with its physical mixture and the pure sample.
Results: Spray dried microspheres exhibited decreased crystallinity. The solubility of microspheres containing Fenofibrate and Pluronic F-127(1:3w/w) exhibited three tenfold increases than the commercial Fenofibrate and dissolution of the same ratio microsphere showed 99 % release in 40 min. While same composition in physical mixture showed 37% release in 20 min.
Conclusion: Consequently, from the above result it can be concluded that spray dried microspheres of Fenofibrate is a useful technique to improve the solubility and dissolution of poor water soluble drug like Fenofibrate.
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References
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