EVALUATION OF CARDIO PROTECTIVE ACTIVITY OF GALANGIN AGAINST DOXORUBICIN INDUCED CARDIOMYOPATHY
Keywords:
Doxorubicin, Cardiotoxicity, Galangin, Vitamin C, CardioprotectiveAbstract
Objective: The present study was designed to investigate the cardioprotective potential of Galangin on Doxorubicin induced cardiotoxicity in rats.
Methods: Albino rats used in this experiment were pretreated with vehicle, Galangin (100 & 200µg/kg) and Vit-C (20 mg/kg) for 28 days. On 25th day, a single dose of Doxorubicin (10 mg/kg, i. p) was administered to groups. After 72 h of Doxorubicin administration, ECG, serum and tissues biomarkers were evaluated. Histopathological examination of the heart was performed.
Results: Doxorubicin treated rats exhibited abnormal ECG pattern followed by significant increase in CK-MB, LDH, SGOT, SGPT and LPO level and decrease in GSH, CAT, TT when compared to control rats. Pretreatment with different doses of Galangin and Vit-C significantly reduced the serum biomarkers and increased the tissue antioxidant level when compared to Doxorubicin alone treated groups. Moreover, pretreatment also improved Doxorubicin induced changes in ECG pattern and histopathology of heart.
Conclusion: We conclude that the present study provides experimental evidence that Galangin has strong antioxidant activity, and it can maintain cell membrane integrity, and ameliorate oxidative stress induced by high-dose of Doxorubicin administration. These findings might be helpful to understand the beneficial effects of Galangin against myocardial injury although further study is needed to confirm its mechanism.
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