1,3,4-THIADIAZOLE: A BIOLOGICALLY ACTIVE SCAFFOLD
Keywords:
1,3,4-Thiadiazole, Thiadiazole, AzoleAbstract
There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, anti allergic, antipsychotic, antimicrobial, antimycobecterial, antitumour, antiviral and antitubercular activities. 1,3,4-thiadiazole constitute an important class of compound for new drug development. They have interesting pharmacophore that display a broad spectrum of biological activity. The 1,3,4-thiadiazole scaffold is an interesting building block that has been used to synthesize a variety of useful bioactive compounds. The stability of thiadiazole nucleus has inspired medicinal chemist to carry out various structural variation in the ring. The marketed drugs such as acetazolamide, methazolamide, globucid proved their therapeutic potential Therefore; many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been instrumental in the development of new 1,3,4-thiadiazole derivatives. This review highlights the various biological activities associated with 1,3,4-thiadiazole ring system.
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